BAY-57-1293
- Product Name
- BAY-57-1293
- CAS No.
- 348086-71-5
- Chemical Name
- BAY-57-1293
- Synonyms
- Pritelivir;N-Methyl-N-(4-methyl-5-sulfamoylthiazol-2-yl)-2-(4-(pyridin-2-yl)phenyl)acetamide;AIC316;CS-857;BAY-57-1293;Pritelivir base;PRITELIVIR;AIC316;BAY571293(Pritelivir);Pritelivir,BAY-57-1293;PRITELIVIR; BAY-57-1293; AIC316
- CBNumber
- CB82627368
- Molecular Formula
- C18H18N4O3S2
- Formula Weight
- 402.49
- MOL File
- 348086-71-5.mol
BAY-57-1293 Property
- Boiling point:
- 639.4±65.0 °C(Predicted)
- Density
- 1.396±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- insoluble in H2O; insoluble in EtOH; ≥13.9 mg/mL in DMSO
- form
- solid
- pka
- 9.31±0.60(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 22129
- Product name
- BAY 57-1293
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 22129
- Product name
- BAY 57-1293
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $160
- Updated
- 2024/03/01
- Product number
- 22129
- Product name
- BAY 57-1293
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $25
- Updated
- 2021/12/16
- Product number
- 22129
- Product name
- BAY 57-1293
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $56
- Updated
- 2024/03/01
- Product number
- 22129
- Product name
- BAY 57-1293
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $112
- Updated
- 2024/03/01
BAY-57-1293 Chemical Properties,Usage,Production
Uses
BAY 57-1293 is a potent inhibitor of herpes simplex virus (HSV) that target the virus helicase primase complex.
Biological Activity
bay 57-1293 is a potent and safe inhibitor of hsv helicase-primase with ic50 value of 12nm [1].bay 57-1293 displays anti-herpes activity through inhibiting the helicase-primase and affecting the viral dna synthesis. in the in vitro viral replication assay, bay 57-1293 shows inhibition against hsv-1 f, hsv-2 g and acyclovir-resistant hsv-1 f mutant with ic50 value of 20nm. in the plaque reduction assay and the conventional cytopathogenicity assay, bay 57-1293 shows ic50 values of 0.01-0.02μm and 0.01-0.03μm, respectively. besides that, bay 57-1293 is active at an ic50 value of 10nm–30nm against all clinical isolates of hsv-1 and hsv-2. furthermore, bay 57-1293 is active in vivo. the oral administration of bay 57-1293 shows 10-fold more potent than valacyclovir in a murine model of disseminated herpes infection. in a rat lethal challenge model, bay 57-1293 exerts profound antiviral activity without toxic effects. [1, 2]
storage
Store at -20°C
References
[1] kleymann g, fischer r, betz u a k, et al. new helicase-primase inhibitors as drug candidates for the treatment of herpes simplex disease. nature medicine, 2002, 8(4): 392-398.
[2] betz u a k, fischer r, kleymann g, et al. potent in vivo antiviral activity of the herpes simplex virus primase-helicase inhibitor bay 57-1293. antimicrobial agents and chemotherapy, 2002, 46(6): 1766-1772.
BAY-57-1293 Preparation Products And Raw materials
Raw materials
Preparation Products
BAY-57-1293 Suppliers
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View Lastest Price from BAY-57-1293 manufacturers
- Product
- BAY-57-1293 348086-71-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-26
- Product
- BAY-57-1293 348086-71-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-07-09