Repertaxin

ChemicalBook > CAS DataBase List > Repertaxin

Product Name: Repertaxin
CAS No.: 266359-83-5
Chemical Name: Repertaxin
Synonyms: CS-2395;DF 1681Y;Reparaxin;Reparixin;Repertaxin;REPARIXIN;DF 1681Y;DF 1681Y;REPERTAXIN;Reparixin (Repertaxin;REPERTAXIN;DF 1681Y;REPARAXIN;Repertaxin(R-configuration, free base form)
CBNumber: CB82628350
Molecular Formula: C14H21NO3S
Formula Weight: 283.39
MOL File: 266359-83-5.mol

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Repertaxin Property

Melting point:: 103-105℃
Density: 1.137±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml)
pka: 4.28±0.40(Predicted)
form: solid
color: White
optical activity: [α]/D -80 to -90°, c =1.0 in ethanol
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Hazard and Precautionary Statements (GHS)

Signal word: Warning

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N-Bromosuccinimide Price

Usbiological

Product number: 464610
Product name: Reparixin
Packaging: 1mg
Price: $319
Updated: 2021/12/16

TRC

Product number: R144575
Product name: Reparixin
Packaging: 25mg
Price: $545
Updated: 2021/12/16

ChemScene

Product number: CS-1379
Product name: Reparixin
Purity: 99.98%
Packaging: 25mg
Price: $500
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008154
Product name: (2R)-N-METHANESULFONYL-2-[4-(2-METHYLPROPYL)PHENYL]PROPANAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $505.43
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb546075
Product name: Reparixin
Purity: >98%
Packaging: 25mg
Price: $402.9
Updated: 2021/12/16

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Repertaxin Chemical Properties,Usage,Production

Description

Reparixin (CAS 266359-83-5) is a noncompetitive allosteric inhibitor of IL-8 (CXCL8) activation of CXCR1 and CXCR2 chemokine receptors (IC50?= 1 and 100 nM, respectively). It blocks a number of activities related to IL-8 signaling, including leukocyte recruitment (IC50?= 1 nM) without affecting receptor activation induced by other CXCR1 and CXCR2 agonists.1?In spontaneously hypertensive rats, 5 mg/kg reparixin administered daily for three weeks was shown to reduce blood pressure by inhibiting hypertension-related mediators.2?It attenuates inflammatory responses and promotes recovery of function after traumatic lesion to the spinal cord.3?Reparixin blockade (100 nM) of CXCR1 has also been used to deplete a cancer stem cell population in human breast cancer cell lines?in vitro.4

Uses

Prevention of delayed graft function in solid organ transplant (CXCL8 inhibitor).

Uses

Reparixin is an inhibitor of CXCR1 and CXCR2 chemokine receptors. Functions as an agent that blocks a range of activities including leukocyte recruitment and IL-8 signaling.

Definition

ChEBI: Reparixin is a monoterpenoid.

References

1) Bertini?et al.?(2004),?Non-competitive allosteric inhibitors of the inflammatory cytokine receptors CXCR1 and CXCR2: prevention of reperfusion injury; Proc. Natl. Acad. Sci. USA,?101?11791 2) Kim?et al. (2011),?Reparixin, an inhibitor of CXCR1 and CXCR2 receptor activation, attenuates blood pressure and hypertension-related mediators expression in spontaneously hypertensive rats; Biol. Pharm. Bull.,?34?120 3) Gorio?et al.?(2007),?Reparixin, an inhibitor of CXCR2 function, attenuates inflammatory responses and promotes recovery of function after traumatic lesion to the spinal cord; J. Pharmacol. Exp. Ther.,?322?973 4) Ginestier?et al.?(2010),?CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts; J. Clin. Invest.,?120?485

Repertaxin Preparation Products And Raw materials

Raw materials

Preparation Products

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266359-83-5