ChemicalBook > CAS DataBase List > 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester

2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester

Product Name
2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester
CAS No.
1280210-79-8
Chemical Name
2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester
Synonyms
tert-butyl 2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate;Omarigliptin Impurity 9;tert-butyl pyrrolo[3,4-c]pyrazole-5(2H,4H,6H)-carboxylate;tert-butyl 4,6-dihydro-2H-pyrrolo[3,4-c]pyrazole-5-carboxylate;5-tert-Butoxycarbonyl-1,4,5,6-tetrahydropyrrolo-[3,4-c]-pyra...;tert-butyl 4,6-dihy dropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate;2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester;2,6-Dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylic acid 1,1-dimethylethyl ester;Pyrrolo[3,4-c]pyrazole-5(4H)-carboxylic acid, 2,6-dihydro-, 1,1-dimethylethyl ester
CBNumber
CB82629665
Molecular Formula
C10H15N3O2
Formula Weight
209.24
MOL File
1280210-79-8.mol
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2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester Property

Boiling point:
366.0±42.0 °C(Predicted)
Density 
1.243±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
14.52±0.20(Predicted)
Appearance
Off-white to light yellow Solid
InChI
InChI=1S/C10H15N3O2/c1-10(2,3)15-9(14)13-5-7-4-11-12-8(7)6-13/h4H,5-6H2,1-3H3,(H,11,12)
InChIKey
IBUNCTVDGYIKAP-UHFFFAOYSA-N
SMILES
N1C=C2CN(C(OC(C)(C)C)=O)CC2=N1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific
Product number
5392AA
Product name
tert-Butyl4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
Packaging
1g
Price
$123
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0394142
Product name
TERT-BUTYL-4,6-DIHYDROPYRROLO[3,4-C]PYRAZOLE-5(2H)-CARBOXYLATE
Purity
95.00%
Packaging
5MG
Price
$501
Updated
2021/12/16
Ambeed
Product number
A122289
Product name
tert-Butyl4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
Purity
97%
Packaging
100mg
Price
$26
Updated
2021/12/16
Ambeed
Product number
A122289
Product name
tert-Butyl4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
Purity
97%
Packaging
250mg
Price
$66
Updated
2021/12/16
Acints
Product number
ACI-02625
Product name
2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylicacidtert-butylester
Purity
95%+
Packaging
1g
Price
$130.5
Updated
2021/12/16
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2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

157327-42-9

1280210-79-8

The reaction of tert-butyl 3-((dimethylamino)methylene)-4-oxopyrrolidine-1-carboxylate (1 g, 4.16 mmol, 1.00 eq.) with hydrazine hydrate (340 mg, 6.79 mmol, 1.63 eq.) in ethanol (10 mL) was stirred for 5 hours at room temperature. Upon completion of the reaction, the mixture was concentrated under vacuum and the resulting residue was purified by silica gel column chromatography with ethyl acetate/petroleum ether as eluent (gradient elution from 1:5 to 1:2). The final product was 250 mg of tert-butyl 4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate in 29% yield as a yellow solid. The product was analyzed by LC/MS (Method C, ESI): retention time RT = 1.30 min, mass spectrum m/z ~ 210.0 [M + H]+.

References

[1] Patent: WO2013/127267, 2013, A1. Location in patent: Page/Page column 97; 98
[2] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 19, p. 5361 - 5366
[3] Patent: EP3144310, 2017, A1

2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester manufacturers

Career Henan Chemical Co
Product
2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester 1280210-79-8
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000KGS
Release date
2020-01-02

1280210-79-8, 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl esterRelated Search:


  • 2,6-Dihydro-4H-pyrrolo[3,4-c]pyrazole-5-carboxylic acid tert-butyl ester
  • tert-butyl 4,6-dihy dropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate
  • Pyrrolo[3,4-c]pyrazole-5(4H)-carboxylic acid, 2,6-dihydro-, 1,1-dimethylethyl ester
  • tert-butyl pyrrolo[3,4-c]pyrazole-5(2H,4H,6H)-carboxylate
  • tert-butyl 2,6-dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylate
  • 2,6-Dihydropyrrolo[3,4-c]pyrazole-5(4H)-carboxylic acid 1,1-dimethylethyl ester
  • Omarigliptin Impurity 9
  • tert-butyl 4,6-dihydro-2H-pyrrolo[3,4-c]pyrazole-5-carboxylate
  • 5-tert-Butoxycarbonyl-1,4,5,6-tetrahydropyrrolo-[3,4-c]-pyra...
  • 1280210-79-8