5-Butyl-1H-pyrazole-3-carboxylic acid
- Product Name
- 5-Butyl-1H-pyrazole-3-carboxylic acid
- CAS No.
- 92933-48-7
- Chemical Name
- 5-Butyl-1H-pyrazole-3-carboxylic acid
- Synonyms
- LUF6283;3-butyl-1H-pyrazole-5-carboxylic acid;5-Butyl-1H-pyrazole-3-carboxylic acid;1H-Pyrazole-3-carboxylic acid, 5-butyl-
- CBNumber
- CB82647450
- Molecular Formula
- C8H12N2O2
- Formula Weight
- 168.19
- MOL File
- 92933-48-7.mol
5-Butyl-1H-pyrazole-3-carboxylic acid Property
- Melting point:
- 166-167 °C
- Boiling point:
- 385.8±30.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DMSO: soluble10mg/mL (clear solution; warmed)
- pka
- 15.44±0.10(Predicted)
- form
- powder
- color
- white to beige
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML0441
- Product name
- LUF6283
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $97.6
- Updated
- 2022/05/15
- Product number
- SML0441
- Product name
- LUF6283
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $392
- Updated
- 2022/05/15
- Product number
- 15423
- Product name
- LUF6283
- Packaging
- 5mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 15423
- Product name
- LUF6283
- Packaging
- 25mg
- Price
- $267
- Updated
- 2024/03/01
- Product number
- 15423
- Product name
- LUF6283
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
5-Butyl-1H-pyrazole-3-carboxylic acid Chemical Properties,Usage,Production
Description
LUF6283 is a partial agonist of GPR109A/HCA2 G protein-coupled receptors (Ki = 0.55 μM in a radioligand binding assay). It stimulates [35S]-GTPγS binding and increases phosphorylation of ERK in HEK293T cells expressing GPR109A/HCA2 receptors (EC50s = 3.1 and 0.32 μM, respectively). In vivo, LUF6283 (400 mg/kg per day) reduces plasma levels of VLDL and hepatic expression of apolipoprotein B in mice.
Uses
LUF 6283 is a partial agonist of HCA2 and is a promising drug candidate to achieve a beneficial lipid lowering effect of niacin, ultimately treating dyslipidemic disorders.
5-Butyl-1H-pyrazole-3-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-Butyl-1H-pyrazole-3-carboxylic acid Suppliers
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