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Boc-NH-PEG(5)-COOH(22atoMs)

Product Name
Boc-NH-PEG(5)-COOH(22atoMs)
CAS No.
391684-36-9
Chemical Name
Boc-NH-PEG(5)-COOH(22atoMs)
Synonyms
Boc-NH-PEG(5)-COOH;NHBoc-PEG6-CH2COOH;Boc-NM-PEG6-CM2COOH;t-Boc-N-amido-PEG6-CH2CO2H;Boc-NH-PEG(5)-COOH(22atoMs);t-boc-N-amido-PEG6-acetic acid;2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid;5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(1,1-dimethylethyl) ester;Inhibitor,Boc-NH-PEG-6-CH2COOH,PROTAC Linkers,BocNHPEG6CH2COOH,Boc NH PEG6 CH2COOH,inhibit;2-(2-(2-(2-(2-(2-t-butyloxycarbonylaminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxyacetatic acid
CBNumber
CB82648725
Molecular Formula
C19H37NO10
Formula Weight
439.5
MOL File
391684-36-9.mol
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Boc-NH-PEG(5)-COOH(22atoMs) Property

Boiling point:
557.7±50.0 °C(Predicted)
Density 
1.134±0.06 g/cm3(Predicted)
refractive index 
n/D 1.4657
storage temp. 
-20°C
pka
3.39±0.10(Predicted)
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
902675
Product name
BocNH-PEG6-acid
Packaging
250mg
Price
$252
Updated
2024/03/01
Sigma-Aldrich
Product number
902675
Product name
BocNH-PEG6-acid
Packaging
1g
Price
$775
Updated
2024/03/01
BroadPharm
Product number
BP-24355
Product name
t-Boc-N-amido-PEG6-CH2CO2H
Purity
98%
Packaging
250mg
Price
$240
Updated
2021/12/16
BroadPharm
Product number
BP-24355
Product name
t-Boc-N-amido-PEG6-CH2CO2H
Purity
98%
Packaging
1g
Price
$540
Updated
2021/12/16
BroadPharm
Product number
BP-24355
Product name
t-Boc-N-amido-PEG6-CH2CO2H
Purity
98%
Packaging
500mg
Price
$380
Updated
2021/12/16
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Boc-NH-PEG(5)-COOH(22atoMs) Chemical Properties,Usage,Production

Description

t-Boc-N-amido-PEG6-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

reaction suitability

reagent type: linker

Boc-NH-PEG(5)-COOH(22atoMs) Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-NH-PEG(5)-COOH(22atoMs) Suppliers

Shanghai Huici Pharmaceutical Technology Co., LTD
Tel
19372841038 19372841038
Email
lixing@pharmahuici.com
Country
China
ProdList
275
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58
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
4986
Advantage
55
T&W GROUP
Tel
021-61551611 13296011611
Fax
+86 21-50676805
Email
contact@trustwe.com
Country
China
ProdList
9895
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51456
Advantage
80
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28806
Advantage
58
Hangzhou HanLai Biochemical Technology Co., Ltd.
Tel
571-86101219 18768477782
Fax
-
Email
sales09@leobiochem.com
Country
China
ProdList
433
Advantage
58
Aikon International Limited
Tel
025-66113011 13155353615
Fax
(7)02557626880
Email
qzhang@aikonchem.com
Country
China
ProdList
15394
Advantage
58
Jilin Province Woda Biotechnology Co., Ltd.
Tel
13504435624
Email
1927928688@qq.com
Country
China
ProdList
1466
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Email
sales@accelachem.com
Country
China
ProdList
11725
Advantage
58

391684-36-9, Boc-NH-PEG(5)-COOH(22atoMs)Related Search:


  • Boc-NH-PEG(5)-COOH(22atoMs)
  • Boc-NH-PEG(5)-COOH
  • Boc-NM-PEG6-CM2COOH
  • 2-(2-(2-(2-(2-(2-t-butyloxycarbonylaminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxyacetatic acid
  • t-Boc-N-amido-PEG6-CH2CO2H
  • t-boc-N-amido-PEG6-acetic acid
  • NHBoc-PEG6-CH2COOH
  • Inhibitor,Boc-NH-PEG-6-CH2COOH,PROTAC Linkers,BocNHPEG6CH2COOH,Boc NH PEG6 CH2COOH,inhibit
  • BocNH-PEG6-CH2COOH/5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(1,1-dimethylethyl) ester
  • 5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(1,1-dimethylethyl) ester
  • 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid
  • 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid, Boc-NH-PEG6-CH2COOH
  • 2-[2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
  • 391684-36-9
  • C19H37NO10