t-Boc-N-amido-PEG5-acid
- Product Name
- t-Boc-N-amido-PEG5-acid
- CAS No.
- 1347750-78-0
- Chemical Name
- t-Boc-N-amido-PEG5-acid
- Synonyms
- BocNH-P5-COOH;BocNH-PEG5-C2-COOH;BOC-PEG5-CH2CH2COOH;Boc-N-amido-PEG5-acid;T-BOC-NH-AMIDO-PEG5-COOH;t-boc-N-amido-PEG5-propionic acid;2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azatricosan-23-oic acid;1-{[(tert-butoxy)carbonyl]amino}-3,6,9,12,15-pentaoxaoctadecan-18-oic acid;5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid, 1-(1,1-dimethylethyl) ester;BocNH-PEG5-CH2CH2COOH/5,8,11,14,17-Pentaoxa-2-azaeicosanedioic acid, 1-(1,1-dimethylethyl) ester
- CBNumber
- CB53062668
- Molecular Formula
- C18H35NO9
- Formula Weight
- 409.47
- MOL File
- 1347750-78-0.mol
t-Boc-N-amido-PEG5-acid Property
- Boiling point:
- 536.9±50.0 °C(Predicted)
- Density
- 1.123±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.28±0.10(Predicted)
- form
- Viscous Liquid
- color
- Colorless to light yellow
Safety
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B603018
- Product name
- t-Boc-N-amido-PEG5-acid
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 0473DY
- Product name
- t-Boc-N-amido-PEG5-acid
- Packaging
- 100mg
- Price
- $154
- Updated
- 2021/12/16
- Product number
- BP-21637
- Product name
- t-Boc-N-amido-PEG5-acid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 280203
- Product name
- Boc-NH-PEG5-CH2CH2COOH
- Packaging
- 1g
- Price
- $405
- Updated
- 2021/12/16
- Product number
- AS118401
- Product name
- 2,2-Dimethyl-4-oxo-3,8,11,14,17,20-hexaoxa-5-azatricosan-23-oicacid
- Purity
- 97+%
- Packaging
- 1g
- Price
- $414
- Updated
- 2021/12/16
t-Boc-N-amido-PEG5-acid Chemical Properties,Usage,Production
Description
t-Boc-N-amido-PEG5-acid is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses
Boc-NH-PEG5-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].
IC 50
PEGs; Alkyl/ether
References
[1] Nathanael Gray, et al. Bifunctional compounds for her3 degradation and methods of use. WO2017117474A1.
t-Boc-N-amido-PEG5-acid Preparation Products And Raw materials
Raw materials
Preparation Products
t-Boc-N-amido-PEG5-acid Suppliers
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View Lastest Price from t-Boc-N-amido-PEG5-acid manufacturers
- Product
- t-Boc-N-amido-PEG5-acid 1347750-78-0
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 5g
- Release date
- 2024-03-25