ChemicalBook > CAS DataBase List > Boc-NH-PEG(5)-COOH(22atoMs)

Boc-NH-PEG(5)-COOH(22atoMs)

Product Name
Boc-NH-PEG(5)-COOH(22atoMs)
CAS No.
391684-36-9
Chemical Name
Boc-NH-PEG(5)-COOH(22atoMs)
Synonyms
Boc-NH-PEG(5)-COOH;NHBoc-PEG6-CH2COOH;Boc-NM-PEG6-CM2COOH;t-Boc-N-amido-PEG6-CH2CO2H;Boc-NH-PEG(5)-COOH(22atoMs);t-boc-N-amido-PEG6-acetic acid;2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid;5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(1,1-dimethylethyl) ester;Inhibitor,Boc-NH-PEG-6-CH2COOH,PROTAC Linkers,BocNHPEG6CH2COOH,Boc NH PEG6 CH2COOH,inhibit;2-(2-(2-(2-(2-(2-t-butyloxycarbonylaminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxyacetatic acid
CBNumber
CB82648725
Molecular Formula
C19H37NO10
Formula Weight
439.5
MOL File
391684-36-9.mol
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Boc-NH-PEG(5)-COOH(22atoMs) Property

Boiling point:
557.7±50.0 °C(Predicted)
Density 
1.134±0.06 g/cm3(Predicted)
storage temp. 
-20°C
pka
3.39±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
902675
Product name
BocNH-PEG6-acid
Packaging
250mg
Price
$252
Updated
2024/03/01
Sigma-Aldrich
Product number
902675
Product name
BocNH-PEG6-acid
Packaging
1g
Price
$775
Updated
2024/03/01
BroadPharm
Product number
BP-24355
Product name
t-Boc-N-amido-PEG6-CH2CO2H
Purity
98%
Packaging
250mg
Price
$240
Updated
2021/12/16
BroadPharm
Product number
BP-24355
Product name
t-Boc-N-amido-PEG6-CH2CO2H
Purity
98%
Packaging
1g
Price
$540
Updated
2021/12/16
BroadPharm
Product number
BP-24355
Product name
t-Boc-N-amido-PEG6-CH2CO2H
Purity
98%
Packaging
500mg
Price
$380
Updated
2021/12/16
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Boc-NH-PEG(5)-COOH(22atoMs) Chemical Properties,Usage,Production

Description

t-Boc-N-amido-PEG6-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Uses

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Boc-NH-PEG(5)-COOH(22atoMs) Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-NH-PEG(5)-COOH(22atoMs) Suppliers

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391684-36-9, Boc-NH-PEG(5)-COOH(22atoMs)Related Search:


  • Boc-NH-PEG(5)-COOH(22atoMs)
  • Boc-NH-PEG(5)-COOH
  • Boc-NM-PEG6-CM2COOH
  • 2-(2-(2-(2-(2-(2-t-butyloxycarbonylaminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxyacetatic acid
  • t-Boc-N-amido-PEG6-CH2CO2H
  • t-boc-N-amido-PEG6-acetic acid
  • NHBoc-PEG6-CH2COOH
  • Inhibitor,Boc-NH-PEG-6-CH2COOH,PROTAC Linkers,BocNHPEG6CH2COOH,Boc NH PEG6 CH2COOH,inhibit
  • BocNH-PEG6-CH2COOH/5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(1,1-dimethylethyl) ester
  • 5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(1,1-dimethylethyl) ester
  • 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid
  • 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid, Boc-NH-PEG6-CH2COOH
  • 2-[2-[2-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]acetic acid
  • 391684-36-9
  • C19H37NO10