ChemicalBook > CAS DataBase List > Boc-NH-PEG(5)-COOH(22atoMs)
Boc-NH-PEG(5)-COOH(22atoMs)
- Product Name
- Boc-NH-PEG(5)-COOH(22atoMs)
- CAS No.
- 391684-36-9
- Chemical Name
- Boc-NH-PEG(5)-COOH(22atoMs)
- Synonyms
- Boc-NH-PEG(5)-COOH;NHBoc-PEG6-CH2COOH;Boc-NM-PEG6-CM2COOH;t-Boc-N-amido-PEG6-CH2CO2H;Boc-NH-PEG(5)-COOH(22atoMs);t-boc-N-amido-PEG6-acetic acid;2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid;5,8,11,14,17,20-Hexaoxa-2-azadocosanedioic acid, 1-(1,1-dimethylethyl) ester;Inhibitor,Boc-NH-PEG-6-CH2COOH,PROTAC Linkers,BocNHPEG6CH2COOH,Boc NH PEG6 CH2COOH,inhibit;2-(2-(2-(2-(2-(2-t-butyloxycarbonylaminoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxyacetatic acid
- CBNumber
- CB82648725
- Molecular Formula
- C19H37NO10
- Formula Weight
- 439.5
- MOL File
- 391684-36-9.mol
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Boc-NH-PEG(5)-COOH(22atoMs) Property
- Boiling point:
- 557.7±50.0 °C(Predicted)
- Density
- 1.134±0.06 g/cm3(Predicted)
- refractive index
- n/D 1.4657
- storage temp.
- -20°C
- pka
- 3.39±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 902675
- Product name
- BocNH-PEG6-acid
- Packaging
- 250mg
- Price
- $252
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 902675
- Product name
- BocNH-PEG6-acid
- Packaging
- 1g
- Price
- $775
- Updated
- 2024/03/01
BroadPharm
- Product number
- BP-24355
- Product name
- t-Boc-N-amido-PEG6-CH2CO2H
- Purity
- 98%
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-24355
- Product name
- t-Boc-N-amido-PEG6-CH2CO2H
- Purity
- 98%
- Packaging
- 1g
- Price
- $540
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-24355
- Product name
- t-Boc-N-amido-PEG6-CH2CO2H
- Purity
- 98%
- Packaging
- 500mg
- Price
- $380
- Updated
- 2021/12/16
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Boc-NH-PEG(5)-COOH(22atoMs) Chemical Properties,Usage,Production
Description
t-Boc-N-amido-PEG6-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Uses
This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
reaction suitability
reagent type: linker
Boc-NH-PEG(5)-COOH(22atoMs) Preparation Products And Raw materials
Raw materials
Preparation Products
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