GI 254023X

ChemicalBook > CAS DataBase List > GI 254023X

Product Name: GI 254023X
CAS No.: 260264-93-5
Chemical Name: GI 254023X
Synonyms: GI4023;GI 254023X;SRI 028594);GI 254023X(GI 4023;GI 254023X;GI-254023X;GI4023;SRI028594;GI254023X; GI 254023X; GI-254023X;GI4023; GI-4023; GI 4023;(R)-N-((S)-3,3-Dimethyl-1-(methylamino)-1-oxobutan-2-yl)-2-((S)-1-(N-hydroxyformamido)ethyl)-5-phenylpentanamide;(2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide;Benzenepentanamide, N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-α-[(1S)-1-(formylhydroxyamino)ethyl]-, (αR)-;(2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide
CBNumber: CB82650737
Molecular Formula: C21H33N3O4
Formula Weight: 391.51
MOL File: 260264-93-5.mol

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GI 254023X Property

Density: 1.112±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble15mg/mL, clear
pka: 8.48±0.69(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0789
Product name: GI254023X
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $212
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0789
Product name: GI254023X
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $847
Updated: 2024/03/01

Cayman Chemical

Product number: 28284
Product name: GI 254023X
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 28284
Product name: GI 254023X
Packaging: 25mg
Price: $479
Updated: 2024/03/01

Cayman Chemical

Product number: 28284
Product name: GI 254023X
Packaging: 5mg
Price: $166
Updated: 2024/03/01

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GI 254023X Chemical Properties,Usage,Production

Uses

GI 254023X is an ADAM10 metaloproteinase inhibitor.

Uses

GI254023X has been used to inhibit ADAM10 (ADAM metallopeptidase domain 10).

Definition

ChEBI: GI254023X is a L-valine derivative that is 3-methyl-L-valine in which carboxy OH group is replaced by a methylnitrilo group and the one of the amino hydrogens is replaced by a (2R)-2-{(1S)-1-[formyl(hydroxy)amino]ethyl}-5-phenylpentanoyl group. It is a potent MMP9 and ADAM10 metalloprotease inhibitor with IC50 of 2.5 and 5.3 nM, respectively. It has a role as an apoptosis inducer, an antineoplastic agent, a matrix metalloproteinase inhibitor and an EC 3.4.24.* (metalloendopeptidase) inhibitor. It is a L-valine derivative, an aldehyde and a member of hydroxylamines.

Biochem/physiol Actions

GI254023X is a potent and selective ADAM10 metalloproteinase inhibitor.

storage

Store at -20°C

GI 254023X Preparation Products And Raw materials

Raw materials

Preparation Products

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260264-93-5, GI 254023XRelated Search:

PRND Nr N,N-Dimethylcyclohexylamine

GI 254023X

(2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide

GI4023

GI 254023X(GI 4023

SRI 028594)

GI 254023X;GI-254023X;GI4023;SRI028594

(2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-2-[(1S)-1-(N-hydroxyformamido)ethyl]-5-phenylpentanamide

((2R,3S)-3-(formyl-hydroxyamino)-2-(3-phenyl-1-propyl)butanoic acid [(1S)-2,2-dimethyl-1-methylcarbamoyl-1-propyl] amide)

(alphaR)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]propyl]-alpha-[(1S)-1-(formylhydroxyamino)ethyl]benzenepentanamide

GI254023X; GI 254023X; GI-254023X;GI4023; GI-4023; GI 4023

Benzenepentanamide, N-[(1S)-2,2-dimethyl-1-[(methylamino)carbonyl]propyl]-α-[(1S)-1-(formylhydroxyamino)ethyl]-, (αR)-

(R)-N-((S)-3,3-Dimethyl-1-(methylamino)-1-oxobutan-2-yl)-2-((S)-1-(N-hydroxyformamido)ethyl)-5-phenylpentanamide

260264-93-5

GI 254023X