ChemicalBook > CAS DataBase List > (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Uses

Product Name: (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone
CAS No.: 915095-87-3
Chemical Name: (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone
Synonyms: Englenet Impurity 18;(2-CHLORO-5-IODOPHENYL)[4-[[(3S)-TETRAHYDRO-3-;(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phen;(S)-(2-Chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)pheny...;(2-chloro-5-iodophenyl)-[4-[(3S)-oxolan-3-yl]oxyphenyl]methanone;(2-chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl];(S)-(2-Chloro-5-iodophenyl)[4-[(tetrahydro-3-furyl)oxy]phenyl]methanone;(S)-(2-chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone;(S)-(2-Chloro-5-iodinephenyl) (4-(four)Hydrofuran-3-oxy)phenyl)methylone;(2-chloro-5-iodophenyl){4-[(3S)-tetrahydrofuran-3-yloxy]phenyl}methanone
CBNumber: CB82651310
Molecular Formula: C17H14ClIO3
Formula Weight: 428.65
MOL File: 915095-87-3.mol

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(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone Property

Melting point:: 109-113oC
Boiling point:: 526℃
Density: 1.639
Flash point:: 272℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form: Solid
color: Off-White to Pale Beige
optical activity: Consistent with structure
InChI: InChI=1S/C17H14ClIO3/c18-16-6-3-12(19)9-15(16)17(20)11-1-4-13(5-2-11)22-14-7-8-21-10-14/h1-6,9,14H,7-8,10H2/t14-/m0/s1
InChIKey: WBBJCIOCSVFCNI-AWEZNQCLSA-N
SMILES: C(C1=CC(I)=CC=C1Cl)(C1=CC=C(O[C@H]2CCOC2)C=C1)=O

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C371265
Product name: (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone
Packaging: 50mg
Price: $50
Updated: 2021/12/16

AK Scientific

Product number: 2954AH
Product name: (S)-(2-Chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
Packaging: 5g
Price: $149
Updated: 2021/12/16

Ambeed

Product number: A150445
Product name: (S)-(2-Chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
Purity: 97%
Packaging: 250mg
Price: $6
Updated: 2021/12/16

Ambeed

Product number: A150445
Product name: (S)-(2-Chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
Purity: 97%
Packaging: 1g
Price: $11
Updated: 2021/12/16

Ambeed

Product number: A150445
Product name: (S)-(2-Chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
Purity: 97%
Packaging: 5g
Price: $32
Updated: 2021/12/16

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(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone Chemical Properties,Usage,Production

Uses

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone is an intermediate of Empagliflozin (E521510) which is a potent and selective SGLT-2 inhibitor that improves glycaemic control syndrome in diabetic rats.

Uses

Synthesis

To a solution of the fluoride VIII.1 (208kg), tetrahydrofuran (407kg) and (S)-3- hydroxytetrahydrofuran (56kg) is added potassium-terf-butanolate solution (20%) in tetrahydrofuran (388kg) within 3 hrs at 16 to 25??C temperature. After completion of the addition, the mixture is stirred for 60min at 20??C temperature. Then the conversion is determined via HPLC analysis. Water (355kg) is added within 20 min at a temperature of 21 ??C (aqueous quench). The reaction mixture is stirred for 30 min (temperature: 20??C). The stirrer is switched off and the mixture is left stand for 60 min (temperature: 20??C). The phases are separated and solvent is distilled off from the organic phase at 19 to 45??C temperature under reduced pressure. 2- Propanol (703kg) is added to the residue at 40 to 46??C temperature and solvent is distilled off at 41 to 50??C temperature under reduced pressure. 2-Propanol (162kg) is added to the residue at 47??C temperature and solvent is distilled off at 40 to 47??C temperature under reduced pressure. Then the mixture is cooled to 0??C within 1 hr 55 min. The product is collected on a centrifuge, washed with a mixture of 2- propanol (158kg) and subsequently with terf.-butylmethylether (88kg) and dried at 19 to 43??C under reduced pressure. 227kg (91 ,8%) of product are obtained as colourless solid. The identity of the product is determined via infrared spectrometry.

References

[1] Patent: WO2011/39107, 2011, A1. Location in patent: Page/Page column 19-20
[2] Patent: US2011/237789, 2011, A1. Location in patent: Page/Page column 11
[3] Patent: US2011/237526, 2011, A1. Location in patent: Page/Page column 7
[4] Organic Letters, 2014, vol. 16, # 16, p. 4090 - 4093
[5] Patent: CN105399735, 2016, A. Location in patent: Paragraph 0040; 0041; 0042

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone 915095-87-3
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10000KGS
Release date: 2024-11-15

Suzhou Nordica Biopharma CO.,LTD

Product: (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone 915095-87-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 0.99
Supply Ability: 5 tons
Release date: 2024-11-14

Shaanxi Dideu Medichem Co. Ltd

Product: (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone 915095-87-3
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-27

915095-87-3, (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanoneRelated Search:

(S)-(5-broMo-2-chlorophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone (3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran Benzo[b]thiophene, 2-[(5-broMo-2-fluorophenyl)Methyl]- (2S,3R,4S,5S,6R)-2-(3-(4-((S)-tetrahydrofuran-3-yloxy)benzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxyMethyl)-2-Methoxy-2H-pyran-3,4,5-triol 2,3,4,6-Tetra-O-benzyl-a-D-glucopyranosylbromide (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran (2-Chloro-5-iodophenyl)(4-fluorophenyl)methanone Methanone, (5-chloro-2-iodophenyl)(2-fluorophenyl)- Butanoic acid, 4-chloro-3-hydroxy-, (3S)- EMpagliflozin iMpurity 10 (3R,4S,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)-2-methoxyoxane-3,4,5-triol (R)-3-(4-(5-broMo-2-chlorobenzyl)phenoxy)tetrahydrofuran Acetoxy Empagliflozin 4-Chlorophenylacetone 4,4'-DDT (5-bromo-2-chlorophenyl)(4-fluorophenyl)methanone 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)benzyl]benzene CHLOROPHENYLSILANE

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

Englenet Impurity 18

Methanone, (2-chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]-

(S)-(2-chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)phenyl)Methanone

(S)-(2-Chloro-5-iodophenyl)(4-(tetrahydrofuran-3-yloxy)pheny...

915095-87-3 (2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methanone

(S)-(2-Chloro-5-iodinephenyl) (4-(four)Hydrofuran-3-oxy)phenyl)methylone

(2-chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]

(2-chloro-5-iodophenyl)-[4-[(3S)-oxolan-3-yl]oxyphenyl]methanone

(2-Chloro-5-iodophenyl) [4- [[(3S) - tetrahydro-3-furanyl] oxy] phenyl] ketone

(S)-(2-Chloro-5-iodophenyl)[4-[(tetrahydro-3-furyl)oxy]phenyl]methanone

(2-CHLORO-5-IODOPHENYL)[4-[[(3S)-TETRAHYDRO-3-

(2-chloro-5-iodophenyl){4-[(3S)-tetrahydrofuran-3-yloxy]phenyl}methanone

(2-Chloro-5-iodophenyl)[4-[[(3S)-tetrahydro-3-furanyl]oxy]phen

915095-87-3

C17H14ClIO3

915095-87-3