tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate
- Product Name
- tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate
- CAS No.
- 287953-38-2
- Chemical Name
- tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate
- Synonyms
- tert-butyl N-(1-methylsulfonylpiperidin-4-yl)carbamate;tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate;[1-(Methylsulfonyl)piperidin-4-yl]carbamic acid tert-butyl ester;Carbamic acid, N-[1-(methylsulfonyl)-4-piperidinyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB82651840
- Molecular Formula
- C11H22N2O4S
- Formula Weight
- 278.37
- MOL File
- 287953-38-2.mol
tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate Property
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 12.12±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- 097346
- Product name
- tert-Butyl (1-(methylsulfonyl)-piperidin-4-yl)carbamate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- CHM0393911
- Product name
- TERT-BUTYL-(1-(METHYLSULFONYL)PIPERIDIN-4-YL)CARBAMATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.74
- Updated
- 2021/12/16
- Product number
- 097346
- Product name
- tert-Butyl (1-(methylsulfonyl)-piperidin-4-yl)carbamate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $588
- Updated
- 2021/12/16
- Product number
- 2853AB
- Product name
- tert-Butyl(1-(methylsulfonyl)piperidin-4-yl)carbamate
- Packaging
- 5g
- Price
- $752
- Updated
- 2021/12/16
- Product number
- A108129
- Product name
- tert-Butyl(1-(methylsulfonyl)piperidin-4-yl)carbamate
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $36
- Updated
- 2021/12/16
tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate Chemical Properties,Usage,Production
Synthesis
124-63-0
73874-95-0
287953-38-2
General procedure for the synthesis of 1-methanesulfonyl-4-tert-butoxycarbonylaminopiperidine from methanesulfonyl chloride and 4-tert-butoxycarbonylaminopiperidine: 5.00 g (25.0 mmol) of Boc-4-aminopiperidine was dissolved in 19.8 mL of pyridine and cooled in an ice bath. 2.13 mL (27.5 mmol) of methanesulfonyl chloride was added slowly and dropwise. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the reaction mixture was diluted with water and then extracted with dichloromethane (DCM). The organic layer was washed with water, dried over anhydrous magnesium sulfate (MgSO4) and filtered. The solvent was removed by concentration under reduced pressure to give 6.30 g of tert-butyl 1-methanesulfonyl-piperidin-4-yl-carbamate. The yield was 91%; ESI-MS: 279 [M + H]+.
References
[1] Patent: WO2014/184327, 2014, A1. Location in patent: Page/Page column 27
[2] Patent: WO2006/77414, 2006, A1. Location in patent: Page/Page column 163-164
[3] Bioorganic Chemistry, 2015, vol. 61, p. 21 - 27
[4] Journal of Medicinal Chemistry, 2006, vol. 49, # 22, p. 6549 - 6560
[5] Patent: US2006/14708, 2006, A1. Location in patent: Page/Page column 13
tert-Butyl (1-(Methylsulfonyl)piperidin-4-yl)carbaMate Preparation Products And Raw materials
Raw materials
Preparation Products
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