TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE
- Product Name
- TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE
- CAS No.
- 1126424-50-7
- Chemical Name
- TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE
- Synonyms
- TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE;1-tert-Butyl 6-Methyl 1H-indazole-1,6-dicarboxylate;1-o-tert-butyl 6-o-methyl Indazole-1,6-dicarboxylate;1-tert-Butyl, 6-meth l lH-indazole-l,6-dicarboxylate;Indazole-1,6-dicarboxylic acid 1-tert-butyl ester 6-Methyl ester;1H-Indazole-1,6-dicarboxylic acid, 1-(1,1-dimethylethyl) 6-methyl ester
- CBNumber
- CB82656931
- Molecular Formula
- C14H16N2O4
- Formula Weight
- 276.29
- MOL File
- 1126424-50-7.mol
TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE Property
- storage temp.
- 2-8°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T204923
- Product name
- 1-tert-Butyl6-Methyl1H-Indazole-1,6-dicarboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- Y5726
- Product name
- tert-Butylmethyl1H-indazole-1,6-dicarboxylate
- Packaging
- 1g
- Price
- $169
- Updated
- 2021/12/16
- Product number
- 126253
- Product name
- 1-tert-Butyl6-methyl1H-indazole-1,6-dicarboxylate
- Purity
- >95%
- Packaging
- 1g
- Price
- $468
- Updated
- 2021/12/16
- Product number
- CHM0387438
- Product name
- 1-TERT-BUTYL-6-METHYL-1H-INDAZOLE-1,6-DICARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.21
- Updated
- 2021/12/16
- Product number
- Y5726
- Product name
- tert-Butylmethyl1H-indazole-1,6-dicarboxylate
- Packaging
- 5g
- Price
- $462
- Updated
- 2021/12/16
TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE Chemical Properties,Usage,Production
Synthesis
24424-99-5
170487-40-8
1126424-50-7
A. General procedure for the synthesis of methyl 1-tert-butoxycarbonyl-1H-indazole-6-carboxylate: methyl 1H-indazole-6-carboxylate (502 mg, 2.84 mmol), 4-dimethylaminopyridine (DMAP, 69 mg, 0.57 mmol), and triethylamine (Et3N, 431 mg, 4.26 mmol) were dissolved in tetrahydrofuran (THF) under cooling in an ice bath (THF, 10 mL). Subsequently, di-tert-butyl dicarbonate (Boc2O, 743 mg, 3.41 mmol) was slowly added to this solution. The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the mixture was concentrated and the residue was extracted with ethyl acetate. The organic phases were combined, concentrated and purified by silica gel column chromatography to afford methyl 1-tert-butoxycarbonyl-1H-indazole-6-carboxylate (797 mg, 100% yield). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 1.74 (9H, s), 3.97 (3H, s), 7.77 (1H, dd, J = 0.4 Hz, J = 8.4 Hz), 7.95 (1H, dd, J = 1.2 Hz, J = 8.4 Hz), 8.21 (1H, d, J = 0.8 Hz), 8.90 (1H s). Mass spectral analysis: calculated value of [M + H]+ (C14H16N2O4) was 277.118 and measured value was 221.
References
[1] Patent: WO2014/89364, 2014, A1. Location in patent: Paragraph 00469; 00470
[2] Patent: WO2009/32125, 2009, A1. Location in patent: Page/Page column 112
[3] Patent: WO2009/32124, 2009, A1. Location in patent: Page/Page column 186-187
[4] Patent: WO2009/152200, 2009, A1. Location in patent: Page/Page column 82
TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL METHYL 1H-INDAZOLE-1,6-DICARBOXYLATE Suppliers
- Tel
- 8485655694
- sales@alchempharmtech.com
- Country
- United States
- ProdList
- 63687
- Advantage
- 58
- Tel
- tp@aladdinsci.com
- Country
- United States
- ProdList
- 52923
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@matrixscientific.com
- Country
- United States
- ProdList
- 6632
- Advantage
- 80