2-(BroMoMethyl)-6-fluoropyridine
- Product Name
- 2-(BroMoMethyl)-6-fluoropyridine
- CAS No.
- 100202-78-6
- Chemical Name
- 2-(BroMoMethyl)-6-fluoropyridine
- Synonyms
- -6-fluoropyridine;6-(bromomethyl)-2-fluoropyridine;2-(BroMoMethyl)-6-fluoropyridine;Pyridine, 2-(bromomethyl)-6-fluoro-
- CBNumber
- CB82660811
- Molecular Formula
- C6H5BrFN
- Formula Weight
- 190.01
- MOL File
- 100202-78-6.mol
2-(BroMoMethyl)-6-fluoropyridine Property
- Boiling point:
- 208.8±25.0 °C(Predicted)
- Density
- 1.632±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.22±0.12(Predicted)
- form
- liquid
- color
- Colourless to light yellow
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B679430
- Product name
- 2-(Bromomethyl)-6-fluoropyridine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB105175
- Product name
- 2-(bromomethyl)-6-fluoropyridine
- Packaging
- 100mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- PC56100
- Product name
- 2-(Bromomethyl)-6-fluoropyridine
- Packaging
- 250mg
- Price
- $116
- Updated
- 2021/12/16
- Product number
- FB105175
- Product name
- 2-(bromomethyl)-6-fluoropyridine
- Packaging
- 250mg
- Price
- $170
- Updated
- 2021/12/16
- Product number
- FB105175
- Product name
- 2-(bromomethyl)-6-fluoropyridine
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
2-(BroMoMethyl)-6-fluoropyridine Chemical Properties,Usage,Production
Synthesis
407-22-7
100202-78-6
The general procedure for the synthesis of 2-(bromomethyl)-6-fluoropyridine from 2-fluoro-6-methylpyridine was as follows: 2-fluoro-6-methylpyridine (4.32 g, 38.9 mmol), N-bromosuccinimide (NBS, 6 g, 33.7 mmol) and azobisisobutyronitrile (AIBN, 0.56 g, 3.4 mmol) were mixed in carbon tetrachloride (CCl4 , 50 mL). The reaction mixture was heated to 80°C and kept stirring for 3 hours. After completion of the reaction, it was cooled to room temperature and insoluble impurities were removed by filtration through diatomaceous earth. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (9:1, v/v). The target fraction was collected and concentrated to give 4 g of the yellow oily product 2-(bromomethyl)-6-fluoropyridine in 54% yield.
References
[1] Patent: CN106749268, 2017, A. Location in patent: Paragraph 0729; 0730
[2] Patent: WO2007/2181, 2007, A2. Location in patent: Page/Page column 148-149
[3] Patent: US2010/69404, 2010, A1. Location in patent: Page/Page column 14
[4] Chemistry - A European Journal, 2016, vol. 22, # 5, p. 1602 - 1607
2-(BroMoMethyl)-6-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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