Description
ChemicalBook > CAS DataBase List > SJB2-043

SJB2-043

Description
Product Name
SJB2-043
CAS No.
63388-44-3
Chemical Name
SJB2-043
Synonyms
SJB2-043;2-Phenylnaphth[2,3-d]oxazole-4,9-dione;2-Phenylnaphtho[2,3-d]oxazole-4,9-dione;Naphth[2,3-d]oxazole-4,9-dione, 2-phenyl-;2-phenylbenzo[f][1,3]benzoxazole-4,9-dione;SJB2-043,inhibit,DUBs,SJB2043,SJB-2-043,SJB2 043,Deubiquitinase,Inhibitor
CBNumber
CB82666686
Molecular Formula
C17H9NO3
Formula Weight
275.26
MOL File
63388-44-3.mol
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SJB2-043 Property

Melting point:
>290℃
Boiling point:
495.0±48.0 °C(Predicted)
Density 
1.373±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
insoluble in H2O; insoluble in EtOH; ≥4.62 mg/mL in DMSO
form 
solid
pka
-3.87±0.20(Predicted)
color 
Green to dark green
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
A3823
Product name
SJB2-043
Packaging
5mg
Price
$233
Updated
2021/12/16
ApexBio Technology
Product number
A3823
Product name
SJB2-043
Packaging
10mM(in 1mL DMSO)
Price
$256
Updated
2021/12/16
ChemScene
Product number
CS-1650
Product name
SJB2-043
Purity
99.25%
Packaging
5mg
Price
$280
Updated
2021/12/16
ApexBio Technology
Product number
A3823
Product name
SJB2-043
Packaging
10mg
Price
$355
Updated
2021/12/16
ChemScene
Product number
CS-1650
Product name
SJB2-043
Purity
99.25%
Packaging
10mg
Price
$426
Updated
2021/12/16
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SJB2-043 Chemical Properties,Usage,Production

Description

SJB2-043 is a potent USP1 inhibitor that inhibits the activity of native USP1/UAF1 with IC50 of 544 nM.

Biological Activity

sjb2-043 is a novel and potent inhibitor of usp1 with ic50 value of 0.544 μm [1].ubiquitin-specific protease 1 (usp1) is a deubiquitinating enzyme (dub) and is a member of the ubiquitin-specific processing (ubp) family of proteases. it deubiquitinates a protein in the dna repair pathway of the fanconi anemia (fa) [1].in the k562 cell line, sjb2-043 decreased usp1 levels in a dose-dependent way and caused degradation of the id1 protein, which resulted from proteasomal degradation. also, sjb2-043 decreased the levels of id2 and id3 proteins. importantly, knockdown of usp1 inhibited cell growth and increased apoptosis. in primary aml cells, sjb2-043 inactivated usp1 and promoted id 1 degradation. in primary human cord blood cd34+ cells, sjb2-043 in low micromolar levels inhibited cell growth. in hela cells, sjb2-043 increased the levels of ub-fancd2 and ub-pcna. and deubiquitination of fancd2 is an important step in the brca/fanconi anemia (fa) dna repair pathway [1].

References

[1]. helena mistry, grace hsieh, sara s, et al. buhrlage, et al. small molecule inhibitors of usp1 target id1 degradation in leukemic cells. mol cancer ther, 2013, 12(12): 2651-2662.

SJB2-043 Preparation Products And Raw materials

Raw materials

Preparation Products

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SJB2-043 Suppliers

MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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info@musechem.com
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United States
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TargetMol Chemicals Inc.
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+1-781-999-5354 +1-00000000000
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marketing@targetmol.com
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United States
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32161
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InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
Country
United States
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Aladdin Scientific
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+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
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ApexBio Technology
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Email
sales@apexbt.com
Country
United States
ProdList
6251
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Cayman Chemical Company
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cayman@caymanchem.com
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United States
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MedChemExpress
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63388-44-3, SJB2-043Related Search:


  • SJB2-043
  • 2-Phenylnaphth[2,3-d]oxazole-4,9-dione
  • 2-phenylbenzo[f][1,3]benzoxazole-4,9-dione
  • Naphth[2,3-d]oxazole-4,9-dione, 2-phenyl-
  • 2-Phenylnaphtho[2,3-d]oxazole-4,9-dione
  • SJB2-043,inhibit,DUBs,SJB2043,SJB-2-043,SJB2 043,Deubiquitinase,Inhibitor
  • 63388-44-3