FGFR inhibitor
- Product Name
- FGFR inhibitor
- CAS No.
- 848318-25-2
- Chemical Name
- FGFR inhibitor
- Synonyms
- CS-1148;SSR128129E;SSR;SSR-128129E;SSR128129E sodium salt;SSR128129E (SSR 128129E;FGFR Inhibitor SSR128129E;SSR128129E; SSR 128129E; SSR-128129E.;Sodium 2-amino-5-(1-methoxy-2-methylindolizine-3-carbonyl)benzoate;Sodium 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate;SSR-128129E,Fibroblast growth factor receptor,Inhibitor,inhibit,SSR128129E,FGFR
- CBNumber
- CB82667577
- Molecular Formula
- C18H15N2NaO4
- Formula Weight
- 346.31247
- MOL File
- 848318-25-2.mol
FGFR inhibitor Property
- Melting point:
- >230°C (dec.)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Yellow
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- 5.33434
- Product name
- FGFR Inhibitor, SSR128129E - CAS 848318-25-2 - Calbiochem
- Purity
- FGFR Inhibitor, SSR128129E, CAS 848318-25-2, is a highly potent, allosteric blocker of multi-fibroblast growth factor receptors. Inhibits selective responses mediated by FGFR1-4.
- Packaging
- 10MG
- Price
- $226
- Updated
- 2023/01/07
- Product number
- 22128
- Product name
- SSR 128129E
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $34
- Updated
- 2024/03/01
- Product number
- 22128
- Product name
- SSR 128129E
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 22128
- Product name
- SSR 128129E
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 22128
- Product name
- SSR 128129E
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $288
- Updated
- 2024/03/01
FGFR inhibitor Chemical Properties,Usage,Production
Uses
SSR128129E (SSR) is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR). Oral delivery of SSR128129E inhibits arthritis and tumors that are relatively refractory to anti-vascular endothelial growth factor receptor-2 antibodies.
Definition
ChEBI: Sodium 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate is an organic sodium salt having 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate as the counterion. It has a role as an antineoplastic agent and a fibroblast growth factor receptor antagonist. It contains a 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate.
Biological Activity
ssr128129e is an allosteric inhibitor of fgfr1 with ic50 value of 1.9 μm [1].the fibroblast growth factor receptors (fgfrs) are receptor tyrosine kinases for fibroblast growth factors (fgfs) and play an important role in cancer and inflammation. fgf2 plays an important role in angiogenesis [1] [2].ssr128129e is an orally-active and allosteric fgfr1 inhibitor. in human umbilical venous endothelial cells (huvecs), ssr128129e inhibited fgf2-induced endothelial cells (ecs) proliferation and migration with ic50 values of 31 and 15.2 nm respectively and also inhibited lamellipodia formation. ssr128129e inhibited responses mediated by fgfr1-4. in fgfr2-expressing hek293 cells, ssr128129e inhibited phosphorylation of frs2 and erk1/2 induced by fgf2 [1].in arthritis mice, ssr128129e inhibited bone and joint damage and reduced angiogenesis in the inflamed joints. in orthotopic panc02 tumor model, ssr128129e (30 mg/kg) inhibited tumor growth by 44%. in murine 4t1 breast tumors, ssr128129e (30 mg/kg) reduced tumor weight and size by 40% and 53%, respectively [1]. in atherosclerosis-prone apolipoprotein e (apoe)-deficient mice, ssr128129e (50 mg/kg) reduced neointimal proliferation and reduced fgfr2 mrna levels and lesion size in the aortic sinus [2].
References
[1]. bono f, de smet f, herbert c, et al. inhibition of tumor angiogenesis and growth by a small-molecule multi-fgf receptor blocker with allosteric properties. cancer cell, 2013, 23(4): 477-488.
[2]. dol-gleizes f, delesque-touchard n, marès am, et al. a new synthetic fgf receptor antagonist inhibits arteriosclerosis in a mouse vein graft model and atherosclerosis in apolipoprotein e-deficient mice. plos one, 2013, 8(11): e80027.
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Raw materials
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