ChemicalBook > CAS DataBase List > Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide

Product Name
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
CAS No.
325970-71-6
Chemical Name
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
Synonyms
L67 >=98% (HPLC);L67, 10 mM in DMSO;DNA LIGASE INHIBITOR; L-67; L 67;Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
CBNumber
CB82668145
Molecular Formula
C16H14Br2N4O4
Formula Weight
486.11
MOL File
325970-71-6.mol
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Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Property

storage temp. 
Store at -20°C
solubility 
DMSO:21.5(Max Conc. mg/mL);44.23(Max Conc. mM)
DMF:10.0(Max Conc. mg/mL);20.57(Max Conc. mM)
Water:1.0(Max Conc. mg/mL);2.06(Max Conc. mM)
form 
A crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

H372Causes damage to organs through prolonged or repeated exposure

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1797
Product name
L67
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$126
Updated
2025/07/31
Cayman Chemical
Product number
22941
Product name
L67
Purity
≥98%
Packaging
5mg
Price
$97
Updated
2024/03/01
Cayman Chemical
Product number
22941
Product name
L67
Purity
≥98%
Packaging
10mg
Price
$184
Updated
2024/03/01
Cayman Chemical
Product number
22941
Product name
L67
Purity
≥98%
Packaging
25mg
Price
$433
Updated
2024/03/01
Cayman Chemical
Product number
22941
Product name
L67
Purity
≥98%
Packaging
50mg
Price
$721
Updated
2024/03/01
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Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Chemical Properties,Usage,Production

Description

L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 μM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (Ki = 10 μM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 μM.

Uses

L 67 is used in the identification and validation of human DNA ligase inhibitors using computer-aided grug design.

IC 50

DNA ligases I: 10 μM (IC50); DNA ligases III: 10 μM (IC50); Caspase-1

References

[1] XI CHEN. Rational design of human DNA ligase inhibitors that target cellular DNA replication and repair.[J]. Cancer research, 2008: 3169-3177. DOI: 10.1158/0008-5472.can-07-6636
[2] ANNAHITA SALLMYR. Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1-Dependent Apoptosis in Cancer Cells.[J]. ACS Chemical Health & Safety, 2016: 5431-5441. DOI: 10.1158/0008-5472.can-15-3243

Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Suppliers

China 35 United States 9 Global 44
Haoyuan Chemexpress Co., Ltd.
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021-58950125
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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Sichuan Wei Keqi Biological Technology Co., Ltd.
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028-81700200 18116577057
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SPIRO PHARMA
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Shanghai EFE Biological Technology Co., Ltd.
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Shanghai YuanYe Biotechnology Co., Ltd.
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02781293128
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Amadis Chemical Company Limited
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325970-71-6, Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazideRelated Search:


  • Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
  • DNA LIGASE INHIBITOR; L-67; L 67
  • L67 >=98% (HPLC)
  • L67, 10 mM in DMSO
  • 325970-71-6
  • C16H14Br2N4O4