ADH 1
- Product Name
- ADH 1
- CAS No.
- 229971-81-7
- Chemical Name
- ADH 1
- Synonyms
- ADH 1;Exherin;CS-2142;Exherin TFA;ADH-1 Exherin;Exherin (ADH-1);L-Cysteinamide, N-acetyl-L-cysteinyl-L-histidyl-L-alanyl-L-valyl-, cyclic (1→5)-disulfide;(4R,7S,10S,13S,16R)-13-((1H-Imidazol-5-yl)methyl)-16-acetamido-7-isopropyl-10-methyl-6,9,12,15-tetraoxo-1,2-dithia-5,8,11,14-tetraazacycloheptadecane-4-carboxamide
- CBNumber
- CB82668226
- Molecular Formula
- C22H34N8O6S2
- Formula Weight
- 570.69
- MOL File
- 229971-81-7.mol
ADH 1 Property
- Boiling point:
- 1183.4±65.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO:2.2(Max Conc. mg/mL);3.86(Max Conc. mM)
- form
- A solid
- pka
- 13.13±0.70(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 29981
- Product name
- ADH-1
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 29981
- Product name
- ADH-1
- Packaging
- 25mg
- Price
- $533
- Updated
- 2024/03/01
- Product number
- 29981
- Product name
- ADH-1
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 29981
- Product name
- ADH-1
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- API0005208
- Product name
- EXHERIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $282.7
- Updated
- 2021/12/16
ADH 1 Chemical Properties,Usage,Production
Uses
ADH-1, an N-cadherin antagonist, inhibits N-cadherin mediated cell adhesion.
Biological Activity
ADH-1 is an N-cadherin (CD325; NCAD) antagonist th at selectively inhibits NCAD-dependent neurite outgrowth (IC50 = 323 μM; PN1-2 r at cerebral neurons on monolayer of chick NCAD-expressing 3T3), while exhibiting no effect against integrin receptor-dependent neurite outgrowth. ADH-1 inhibits NCAD-mediated signaling events in cultures (0.2-2.5 mg/mL) and exhibits anti-tumor efficacy in vivo (50-100 mg/kg i.p. in rats and mice).
in vivo
ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells[1].
ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model[2].
In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts[3].
References
[1] Shintani Y, et al. ADH-1 suppresses N-cadherin-dependent pancreatic cancer progression. Int J Cancer. 2008 Jan 1;122(1):71-7. DOI:10.1002/ijc.23027
[2] Li H, et al. ADH1, an N-cadherin inhibitor, evaluated in preclinical models of angiogenesis and androgen-independent prostate cancer. Anticancer Drugs. 2007 Jun;18(5):563-8. DOI:10.1097/CAD.0b013e328020043e
[3] Turley RS, et al. Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma. Ann Surg. 2015 Feb;261(2):368-77 DOI:10.1097/SLA.0000000000000635
ADH 1 Preparation Products And Raw materials
Raw materials
Preparation Products
ADH 1 Suppliers
- Tel
- +81-8027837258; +8108027837258
- Fax
- 0081-80278372055
- sales@adachibio.com
- Country
- Japan
- ProdList
- 992
- Advantage
- 58
View Lastest Price from ADH 1 manufacturers
- Product
- ADH 1 229971-81-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16
- Product
- ADH 1 229971-81-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-02-16