4-tert-butyl-2-chloropyridine
Uses- Product Name
- 4-tert-butyl-2-chloropyridine
- CAS No.
- 81167-60-4
- Chemical Name
- 4-tert-butyl-2-chloropyridine
- Synonyms
- 2-chloro-4-tert-butylpyride;2-Chloro-4-tert-butylpyridine;4-tert-butyl-2-chloropyridine;4-(tert-Butyl)-2-chloropyridine;2-chloro-4-(1,1-dimethylethyl)-Pyridine;Pyridine, 2-chloro-4-(1,1-dimethylethyl)-;(2-Bromo-5-methoxy-27-methyl-phenyl)-methano;4-tert-butyl-2-chloropyridine4-tert-butyl-2-chloropyridine
- CBNumber
- CB82668736
- Molecular Formula
- C9H12ClN
- Formula Weight
- 169.65
- MOL File
- 81167-60-4.mol
4-tert-butyl-2-chloropyridine Property
- Boiling point:
- 223.8±20.0 °C(Predicted)
- Density
- 1.051±0.06 g/cm3(Predicted)
- refractive index
- 1.5130 to 1.5170
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- clear liquid
- pka
- 1.04±0.10(Predicted)
- color
- Colorless to Almost colorless
- InChI
- InChI=1S/C9H12ClN/c1-9(2,3)7-4-5-11-8(10)6-7/h4-6H,1-3H3
- InChIKey
- UGGNULHQVUWRGQ-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(C(C)(C)C)=C1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B5466
- Product name
- 4-(tert-Butyl)-2-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $151
- Updated
- 2025/07/31
- Product number
- B5466
- Product name
- 4-(tert-Butyl)-2-chloropyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $516
- Updated
- 2025/07/31
- Product number
- B814068
- Product name
- 4-(tert-Butyl)-2-chloropyridine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 3H32-5-LQ
- Product name
- 4-tert-Butyl-2-chloropyridine
- Purity
- 95.0%
- Packaging
- 500mg
- Price
- $184
- Updated
- 2021/12/16
- Product number
- 44691
- Product name
- 4-(tert-Butyl)-2-chloropyridine,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 1G
- Price
- $208
- Updated
- 2021/12/16
4-tert-butyl-2-chloropyridine Chemical Properties,Usage,Production
Uses
4-(tert-butyl)-2-chloropyridine is used as an intermediate in organic synthesis.
Synthesis
23569-17-7
81167-60-4
General procedure for the synthesis of 4-(tert-butyl)-2-chloropyridine from 4-tert-butylpyridine 1-oxide: 4-tert-butylpyridine 1-oxide (5 g, 33.07 mmol) was placed in a two-necked flask. The double-necked flask was cooled in an ice bath and 25 ml of phosphoryl chloride (POCl3) was slowly added to the double-necked flask to form a reaction mixture. The mixture was heated under reflux conditions for 24 hours to complete the reaction. After completion of the reaction, the temperature was slowly reduced to 20°C and the solvent was removed by distillation under reduced pressure. The reaction mixture was neutralized by adding aqueous sodium carbonate solution to a two-necked flask, followed by extraction of the reaction mixture with ethyl acetate and collection of the organic layer. The organic layer was dried over anhydrous sodium sulfate (Na2SO4) to give the crude product. The crude product was purified by column chromatography (silica gel as stationary phase, eluent ratio of ethyl acetate: n-hexane = 1:6) to give 4-(tert-butyl)-2-chloropyridine (4 g, 72% yield) as a clear liquid. The structure of the compound was confirmed by 1H-NMR (400 MHz, CDCl3): δ8.27 (d, J=5.3 Hz, 1H), 7.28 (s, 1H), 7.19 (dd, J=5.2 Hz, 1.6 Hz, 1H), 1.29 (s, 9H).
References
[1] Organometallics, 2011, vol. 30, # 24, p. 6751 - 6765
[2] Synthesis (Germany), 2013, vol. 45, # 22, p. 3099 - 3102
[3] Patent: US9219237, 2015, B1. Location in patent: Page/Page column 13
[4] Patent: WO2012/41476, 2012, A1. Location in patent: Page/Page column 52
[5] Inorganica Chimica Acta, 2012, vol. 383, p. 316 - 319
4-tert-butyl-2-chloropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-tert-butyl-2-chloropyridine manufacturers
- Product
- 4-tert-butyl-2-chloropyridine 81167-60-4
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10
- Release date
- 2021-12-15
- Product
- 4-tert-butyl-2-chloropyridine 81167-60-4
- Price
- US $2.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100g , 1kg, 5kg , 50kg
- Release date
- 2020-01-07