(-)-D-PYROGLUTAMIC ACID METHYL ESTER

Product Name: (-)-D-PYROGLUTAMIC ACID METHYL ESTER
CAS No.: 64700-65-8
Chemical Name: (-)-D-PYROGLUTAMIC ACID METHYL ESTER
Synonyms: Methyl (R)-5-oxopyrrolidine-2-carboxylate;(R)-METHYL 5-OXOPYRROLIDINE-2-CARBOXYLATE;D-PYR-OME;Methyl D-pyroglutaMate;Methyl (R)-pyroglutamate;5-Oxo-D-proline methyl ester;Methyl (R)-(-)-2-pyrrolidinone;Methyl D-Pyroglutamate,99%e.e.;D-Proline, 5-oxo-, Methyl ester;(R)-PYROGLUTAMIC ACID METHYL ESTER
CBNumber: CB8267122
Molecular Formula: C6H9NO3
Formula Weight: 143.14
MOL File: 64700-65-8.mol

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(-)-D-PYROGLUTAMIC ACID METHYL ESTER Property

Boiling point:: 83℃/0.25mm
Density: 1.226
storage temp.: Sealed in dry,Room Temperature
solubility: Dichloromethane
form: Oil
pka: 14.65±0.40(Predicted)
color: Clear
Sensitive: Moisture Sensitive
InChI: InChI=1S/C6H9NO3/c1-10-6(9)4-2-3-5(8)7-4/h4H,2-3H2,1H3,(H,7,8)/t4-/m1/s1
InChIKey: HQGPKMSGXAUKHT-SCSAIBSYSA-N
SMILES: C(OC)(=O)[C@H]1CCC(=O)N1

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Safety

HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M137985
Product name: (R)-Methyl5-Oxopyrrolidine-2-carboxylate
Packaging: 10g
Price: $135
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-FM
Product name: (D)-Pyroglutamic acid methyl ester
Packaging: 25g
Price: $395
Updated: 2021/12/16

Activate Scientific

Product number: AS22135
Product name: Methyl (R)-2-pyrrolidone-5-carboxylate
Purity: 97+% ee
Packaging: 25g
Price: $401
Updated: 2021/12/16

AK Scientific

Product number: J98545
Product name: MethylD-pyroglutamate
Packaging: 5g
Price: $65
Updated: 2021/12/16

Activate Scientific

Product number: AS22135
Product name: Methyl (R)-2-pyrrolidone-5-carboxylate
Purity: 97+% ee
Packaging: 5G
Price: $118
Updated: 2021/12/16

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(-)-D-PYROGLUTAMIC ACID METHYL ESTER Chemical Properties,Usage,Production

Uses

(R)-Methyl 5-Oxopyrrolidine-2-carboxylate, is a building block used in various chemical synthesis such as in preparation of phenylpropiolic acid derivatives as novel GPR40 agonists.

Synthesis

67-56-1

149-87-1

4931-66-2

The general procedure for the synthesis of methyl (S)-(+)-2-pyrrolidone-5-carboxylate from methanol and DL-pyroglutamic acid was as follows: DL-pyroglutamic acid (2150 g, 16.65 mol) was dissolved in a solvent mixture of methanol (2.0 L) and chloroform (2.0 L), and methanesulfonic acid (80 g, 0.83 mol) was added. This mixture was transferred to a Soxhlet extraction apparatus fitted with 3? molecular sieves and the reaction was refluxed under mechanical stirring for 5 days. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford methyl (S)-(+)-2-pyrrolidone-5-carboxylate as a yellow oil in 98% yield (16.3 mmol). The product could be used in the next reaction without further purification and its physicochemical properties were consistent with those reported in the literature.1H NMR (CDCl3, 400 MHz) δ ppm: 2.08-2.50 (m, 4H, CHCH2CH2), 3.77 (s, 3H, CH3), 4.29 (m, 1H, CH2CH2CH), 7.62 (br s, 1H, NH). NH).

References

[1] Journal of Heterocyclic Chemistry, 1991, vol. 28, # 4, p. 1143 - 1146
[2] Synthesis (Germany), 2016, vol. 48, # 14, p. 2226 - 2244
[3] Journal of the American Chemical Society, 1987, vol. 109, # 25, p. 7925 - 7926
[4] Chemistry - A European Journal, 2005, vol. 11, # 8, p. 2577 - 2590
[5] Patent: EP2098526, 2009, A1. Location in patent: Page/Page column 13

(-)-D-PYROGLUTAMIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-D-PYROGLUTAMIC ACID METHYL ESTER Suppliers

China 69 Germany 1 India 2 United Kingdom 3 United States 10 Global 85

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View Lastest Price from (-)-D-PYROGLUTAMIC ACID METHYL ESTER manufacturers

Career Henan Chemical Co

Product: (-)-D-PYROGLUTAMIC ACID METHYL ESTER 64700-65-8
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-25

64700-65-8, (-)-D-PYROGLUTAMIC ACID METHYL ESTERRelated Search:

3-Cyano-5-fluorobenzoic acid 3,5-diamino-4-methyl-benzoic acid 4-Chloro-5-(chlorosulfonyl)-2-fluorobenzoic acid 4-Cyanobenzoic acid 2,4-Dichloro-5-fluorobenzoic acid 2,5-Dichloro-3-fluorobenzoic acid 2-Chloro-5-(trifluoromethyl)benzoic acid 2-Chloro-6-(trifluoromethyl)be 2,6-DIBROMOBENZOIC ACID 1-Methyl-L-pyroglutamic acid methyl ester BOC-L-Pyroglutamic acid methyl ester hydrochloride L-PYROGLUTAMIC ACID METHYL ESTER,(+)-L-PYROGLUTAMIC ACID METHYL ESTER,(S)-PYROGLUTAMIC ACID METHYL ESTER,Pyroglutamic acid methyl ester N-tert-Butoxycarbonyl-L-pyroglutamic acid methyl ester,BOC-L-PYROGLUTAMIC ACID METHYL ESTER

(R)-PYROGLUTAMIC ACID METHYL ESTER

(-)-D-PYROGLUTAMIC ACID METHYL ESTER

(D)-PYROGLUTAMIC ACID METHYL ESTER

METHYL (R)-2-PYRROLIDINE-5-CARBOXYLATE

D-PYR-OME

METHYL (R)-(+)-2-PYRROLIDONE-5-CARBOXYLATE

Methyl (R)-(-)-2-pyrrolidinone

Methyl D-pyroglutaMate

(R)-Methyl 2-pyrrolidone-5-carboxylate

5-Oxo-D-proline methyl ester

(R)-METHYL 5-OXOPYRROLIDINE-2-CARBOXYLATE

Methyl (R)-(-)-2-pyrrolidinone-5-carboxylate, 98%

Methyl (R)-5-oxopyrrolidine-2-carboxylate

methyl (2R)-5-oxopyrrolidine-2-carboxylate

Methyl (R)-pyroglutamate

D-Proline, 5-oxo-, Methyl ester

Methyl D-Pyroglutamate,99%e.e.

(-)-D-PYROGLUTAMIC ACID METHYL ESTER

64700-65-8