Boc-L-Pyroglutamic acid methyl ester

Product Name: Boc-L-Pyroglutamic acid methyl ester
CAS No.: 108963-96-8
Chemical Name: Boc-L-Pyroglutamic acid methyl ester
Synonyms: (S)-1-tert-Butyl 2-Methyl 5-oxopyrrolidine-1,2-dicarboxylate;BOC-PYR-OME;(S)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE;1-tert-Butyl 2-Methyl (2S)-5-Oxopyrrolidine-1,2-dicarboxylate;utamate;Boc-pGlu-OMe;BOC-L-Pyr.Ome;Boc-Pyr-OMe 99%;Boc-L-Pyroglutamic a;Methyl (L)-N-Boc-pyroglu
CBNumber: CB7717837
Molecular Formula: C11H17NO5
Formula Weight: 243.26
MOL File: 108963-96-8.mol

More

Less

Boc-L-Pyroglutamic acid methyl ester Property

Melting point:: 68-72 °C 69-74 °C
Boiling point:: 361.6±35.0 °C(Predicted)
Density: 1.209±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in dichloromethane.
pka: -4.28±0.40(Predicted)
form: powder to crystal
color: White to Almost white
optical activity: [α]22/D 32.0°, c = 0.5 in chloroform &_& [α]22/D -32°, c = 0.5% in chloroform
InChI: InChI=1S/C11H17NO5/c1-11(2,3)17-10(15)12-7(9(14)16-4)5-6-8(12)13/h7H,5-6H2,1-4H3/t7-/m0/s1
InChIKey: FNTAOUUEQHKLIU-ZETCQYMHSA-N
SMILES: N1(C(OC(C)(C)C)=O)C(=O)CC[C@H]1C(OC)=O
CAS DataBase Reference: 108963-96-8(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xn,N
Risk Statements: 36-43-50
Safety Statements: 26-36/37-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HazardClass: 9
HS Code: 29337900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 757497
Product name: Boc-Pyr-OMe
Purity: 97%
Packaging: 1g
Price: $33
Updated: 2023/06/20

Sigma-Aldrich

Product number: 738182
Product name: Methyl (S)-Boc-5-pyrrolidone-2-carboxylate
Purity: 97%
Packaging: 1g
Price: $40.4
Updated: 2023/01/07

TCI Chemical

Product number: M2803
Product name: Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate
Purity: >98.0%(GC)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TCI Chemical

Product number: M2803
Product name: Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate
Purity: >98.0%(GC)
Packaging: 25g
Price: $237
Updated: 2025/07/31

TRC

Product number: M294429
Product name: Methyl(2S)-1-(tert-butoxycarbonyl)pyroglutamate
Packaging: 5g
Price: $115
Updated: 2021/12/16

More

Less

Boc-L-Pyroglutamic acid methyl ester Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

Methyl (S)-1-Boc-5-oxopyrrolidine-2-carboxylate in medicine, pharmacy, cosmetics, and industrial, artificial flavoring and fragrance agents

Synthesis

67-56-1

24424-99-5

98-79-3

108963-96-8

(1) Synthesis of (2S)-5-oxopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (Compound 3): L-pyroglutamic acid (15.0 g) was suspended in methanol (60.0 mL), and thionyl chloride (27.6 g) was slowly added with stirring at a temperature lower than 30°C. The reaction was completed after 1 hour by HPLC. After 1 hr of reaction, HPLC monitoring showed completion of the reaction. The solvent was removed by distillation under reduced pressure and the residue was dissolved in ethyl acetate (200 mL). Triethylamine (13.5 g) was slowly added at a temperature below 30 °C, followed by filtration of the mixture. To the filtrate was added DMAP (1.5 g) in a single addition, followed by di-tert-butyl dicarbonate (Boc2O, 27.8 g) at a temperature below 30 °C. After HPLC monitoring showed the reaction to be complete, the mixture was cooled to 0 °C and 1N HCl (13.0 mL) was added and stirred at a temperature below 30 °C for 10 min. The organic layer was separated, washed with H2O (20.0 mL) and the solvent was evaporated under reduced pressure. To the resulting residue was added tert-butyl methyl ether (27.0 mL) and cooled to 0°C with stirring. The slowly precipitated crystals were filtered to give compound 3 (21.9 g, 77.3% yield).

References

[1] Patent: WO2010/9014, 2010, A2. Location in patent: Page/Page column 6
[2] Patent: CN106336371, 2017, A. Location in patent: Paragraph 0050; 0051

Boc-L-Pyroglutamic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Boc-L-Pyroglutamic acid methyl ester Suppliers

Americas 1 Canada 1 China 283 Europe 2 France 2 Germany 2 India 19 Japan 1 The Netherlands 1 United Kingdom 6 United States 19 Global 337

Shanghai Chiral Chemicals Inc.

Tel: 021-37285021 13472570865
Fax: 86-021-51714507
Email: tym7xi@aliyun.com
Country: China
ProdList: 308
Advantage: 64

Shanghai Baoboluo New Material Technology Co., Ltd

Tel: 15572878882 15572878882
Email: 13659842429@163.com
Country: China
ProdList: 26
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

future industrial shanghai co., ltd

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: sales@jonln.com
Country: China
ProdList: 1995
Advantage: 65

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

Sichuan Tongsheng Amino acids Co.,Ltd.

Tel: 0838-2274206 13908101207
Fax: +86-838-2274207
Email: sales@biots.cn
Country: China
ProdList: 279
Advantage: 66

Beijing HwrkChemical Technology Co., Ltd

Tel: 18515581800 18501085097
Fax: 010-89508210
Email: sales.bj@hwrkchemical.com
Country: China
ProdList: 9400
Advantage: 55

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

More

Less

View Lastest Price from Boc-L-Pyroglutamic acid methyl ester manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Boc-L-Pyroglutamic acid methyl ester 108963-96-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-05-07

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-L-Pyroglutamic acid methyl ester 108963-96-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500kg/month
Release date: 2021-07-22

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Pyroglutamic acid methyl ester 108963-96-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-21

108963-96-8, Boc-L-Pyroglutamic acid methyl esterRelated Search:

L-Glutamic acid Ethopabate Glycine methyl ester hydrochloride Methyl salicylate L-Pyroglutamic acid Polyglutamic acid METSULFURON METHYL Kresoxim-methyl Methyl acrylate Methyl acetate Tribenuron methyl GLDH (R)-N-Boc-glutamic acid-1,5-dimethyl ester N-Carbobenzyloxyglycine Methyl L-pyroglutamate 1,1'-Carbonyldiimidazole Thiophanate-methyl Methyl

(S)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE

(S)-METHYL-N-BOC-PYROGLUTAMATE

BOC-L-PYROGLUTAMIC ACID METHYL ESTER

BOC-PYR-OME

(S)-N-(tert-Butoxycarbonyl)-2-pyrrolidinone-5-carboxylic acid methyl

Methyl Boc-L-Pyroglutamate

1,2-Pyrrolidinecarboxylic acid 5-oxo,1-(tertButyl)-2-methylester

N-tert-Butoxycarbonyl-L-pyroglutamic acid methyl ester

METHYL L-N-BOC-PYROGLUTAMATE

Boc-pGlu-OMe

Methyl (S)-N-(tert-butoxycarbonyl)pyroglutamate

Boc-L-Pyroglutamic a

N-BOC-L-Methyl pyroglutaMate

1-tert-Butyl 2-Methyl (2S)-5-Oxopyrrolidine-1,2-dicarboxylate

(S)-N-(tert-butoxycarbonyl)pyroglutaMate

Methyl (L)-N-Boc-pyroglu

Methyl (S)-Boc-2-pyrrolidone-5-carboxylate

Methyl (S)-N-Boc-5-pyrrolidone-2-carboxylate

N-Boc-(S)-2-pyrrolidone-5-carboxylic acid methyl ester

N-Boc-5-oxo-L-proline methyl ester

N-Boc-L-Pyroglutamic acid methyl ester

(2S)-5-oxo-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester

Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate

1,2-Pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)-

Methyl (S)-Boc-5-pyrrolidone-2-carboxylate

(S)-1-tert-Butyl 2-Methyl 5-oxopyrrolidine-1,2-dicarboxylate

Methyl (S)-1-Boc-5-oxopyrrolidine-2-carboxylate, 98%

BOC-L-Pyr.Ome

utamate

Boc-l-methyl pyroglutamate

Methyl(S)-1-Boc-5-oxopyrrolidine-2-carboxylate,98%

(S)-1-(tert-Butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic Acid Methyl Ester

Methyl (S)-1-(tert-Butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate

Methyl N-Boc-L-pyroglutamate

N-Boc-L-pyroglutamic Acid M

Boc-L-Pyroglutamic acid methyl ester USP/EP/BP

Methyl t-butoxycarbonyl-l-pyroglutamate

1-O-tert-butyl 2-O-methyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate

TIANFU CHEM 108963-96-8 Boc-L-Pyroglutamic acid methyl ester

1-(tert-Butyl) 2-methyl (S)-5-oxopyrrolidine-1,2-dicarboxylate

Boc-L-Pyroglutamic methyl ester

Boc-L-Pyroglutamic acid methyl ester,97%

Methyl (<i>S</i>)-Boc-5-pyrrolidone-2-carboxylate

Methyl L-N-Boc-Pyroglutamate, CAS 108963-96-8

Boc-Pyr-OMe 99%

108963-96-8

Chiral Reagents

Pyroglutamic acid [Pyr, pGu]

Amino Acids and Derivatives

pharmacetical

AMINOACIDS DERIVATIVES