(R)-N-Boc-glutamic acid-1,5-dimethyl ester
- Product Name
- (R)-N-Boc-glutamic acid-1,5-dimethyl ester
- CAS No.
- 59279-60-6
- Chemical Name
- (R)-N-Boc-glutamic acid-1,5-dimethyl ester
- Synonyms
- N-Boc-L-Glutamic acid dimethyl ester;BOC-GLU(OME)-OME;BOC-L-GLU(OME)-OME;Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate;BOC-GLU(OME)-OME 45G;BOC-L-GLUTAMIC ACID DIMETHYL ESTER;dimethyl(tert-butoxycarbonyl)-L-glutamate;(S)-diMethyl 2-(tert-butoxycarbonylaMino)pentanedioate;BOC-L-GLU(ME)-OME;Dimethyl (2S)-2-(tert-butoxycarbonylamino)pentanedioate
- CBNumber
- CB5853917
- Molecular Formula
- C12H21NO6
- Formula Weight
- 275.3
- MOL File
- 59279-60-6.mol
(R)-N-Boc-glutamic acid-1,5-dimethyl ester Property
- Melting point:
- 43.0 to 47.0 °C
- Boiling point:
- 370.9±32.0 °C(Predicted)
- Density
- 1.117±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- pka
- 10.86±0.46(Predicted)
- form
- Liquid
- color
- Colorless to pale yellow
- CAS DataBase Reference
- 59279-60-6(CAS DataBase Reference)
Safety
- HS Code
- 2922420090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D4536
- Product name
- Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 1g
- Price
- $30
- Updated
- 2024/03/01
- Product number
- D4536
- Product name
- Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate
- Purity
- >98.0%(HPLC)(N)
- Packaging
- 5g
- Price
- $87
- Updated
- 2024/03/01
- Product number
- H62056
- Product name
- N-Boc-L-glutamic acid 1,5-dimethyl ester, 97%
- Packaging
- 5g
- Price
- $62.65
- Updated
- 2024/03/01
- Product number
- H62056
- Product name
- N-Boc-L-glutamic acid 1,5-dimethyl ester, 97%
- Packaging
- 25g
- Price
- $260.65
- Updated
- 2024/03/01
- Product number
- B600185
- Product name
- N-Boc-L-glutamicAcid1,5-DimethylEster
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
(R)-N-Boc-glutamic acid-1,5-dimethyl ester Chemical Properties,Usage,Production
Uses
(R)-N-Boc-glutamic acid-1,5-dimethyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical production processes.
Synthesis
L-glutamic acid (10.0 g, 67.97 mmol) was dissolved in 200 mL of methanol, and SOCl2(10.85 mL, 149.53 mmol)was slowly added dropwise under an ice bath. After the addition, reflux was performed at 65 ?? C. After 2 hours, the reaction system was cooled to room temperature, and methanol was evaporated to dryness under reduced pressure to obtain a colorless viscous substance.This colorless viscous substance was dissolved in 200 mL of THF, (Boc)2O (22.25 g, 101.95 mmol) was addedunder an ice bath, and triethylamine (14.13 mL, 101.95 mmol) was slowly added dropwise.After the addition was complete, the reaction was allowed to proceed at room temperature overnight.After completion of the reaction, the solvent was distilled off under reduced pressure.The residue was dissolved in 200 mL of dichloromethane.The organic phase was washed with water (200 mL * 2), saturated citric acid solution (200 mL * 2), saturated sodium bicarbonate solution (200 mL * 2), and saturated brine (200 mL * 2) in that order.The organic phase was dried over anhydrous Na2SO4. Thefiltrate was collected by filtration, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 4: 1 v / v) to give a colorless oily product (R)-N-Boc-glutamic acid-1,5-dimethyl ester (18.34 g, yield 98%)
(R)-N-Boc-glutamic acid-1,5-dimethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-N-Boc-glutamic acid-1,5-dimethyl ester manufacturers
- Product
- Boc-L-Glu(Ome)-Ome 59279-60-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2023-09-23
- Product
- (R)-N-Boc-glutamic acid-1,5-dimethyl ester 59279-60-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 99
- Supply Ability
- 20tons
- Release date
- 2024-02-06
- Product
- (R)-N-Boc-glutamic acid-1,5-dimethyl ester 59279-60-6
- Price
- US $32.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 200
- Release date
- 2023-02-16