ChemicalBook > CAS DataBase List > (R)-N-Boc-glutamic acid-1,5-dimethyl ester

(R)-N-Boc-glutamic acid-1,5-dimethyl ester

Product Name
(R)-N-Boc-glutamic acid-1,5-dimethyl ester
CAS No.
59279-60-6
Chemical Name
(R)-N-Boc-glutamic acid-1,5-dimethyl ester
Synonyms
N-Boc-L-Glutamic acid dimethyl ester;BOC-GLU(OME)-OME;BOC-L-GLU(OME)-OME;Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate;BOC-GLU(OME)-OME 45G;BOC-L-GLUTAMIC ACID DIMETHYL ESTER;dimethyl(tert-butoxycarbonyl)-L-glutamate;(S)-diMethyl 2-(tert-butoxycarbonylaMino)pentanedioate;BOC-L-GLU(ME)-OME;Dimethyl (2S)-2-(tert-butoxycarbonylamino)pentanedioate
CBNumber
CB5853917
Molecular Formula
C12H21NO6
Formula Weight
275.3
MOL File
59279-60-6.mol
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(R)-N-Boc-glutamic acid-1,5-dimethyl ester Property

Melting point:
43.0 to 47.0 °C
Boiling point:
370.9±32.0 °C(Predicted)
Density 
1.117±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly)
pka
10.86±0.46(Predicted)
form 
Liquid
color 
Colorless to pale yellow
InChI
InChI=1S/C12H21NO6/c1-12(2,3)19-11(16)13-8(10(15)18-5)6-7-9(14)17-4/h8H,6-7H2,1-5H3,(H,13,16)/t8-/m0/s1
InChIKey
QNSPKWUAZQIIGZ-QMMMGPOBSA-N
SMILES
C(OC)(=O)[C@H](CCC(OC)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference
59279-60-6(CAS DataBase Reference)
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Safety

HS Code 
2922420090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4536
Product name
Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$30
Updated
2024/03/01
TCI Chemical
Product number
D4536
Product name
Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$87
Updated
2024/03/01
Alfa Aesar
Product number
H62056
Product name
N-Boc-L-glutamic acid 1,5-dimethyl ester, 97%
Packaging
5g
Price
$62.65
Updated
2024/03/01
Alfa Aesar
Product number
H62056
Product name
N-Boc-L-glutamic acid 1,5-dimethyl ester, 97%
Packaging
25g
Price
$260.65
Updated
2024/03/01
TRC
Product number
B600185
Product name
N-Boc-L-glutamicAcid1,5-DimethylEster
Packaging
5g
Price
$80
Updated
2021/12/16
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(R)-N-Boc-glutamic acid-1,5-dimethyl ester Chemical Properties,Usage,Production

Uses

(R)-N-Boc-glutamic acid-1,5-dimethyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical production processes.

Synthesis


L-glutamic acid (10.0 g, 67.97 mmol) was dissolved in 200 mL of methanol, and SOCl2(10.85 mL, 149.53 mmol)was slowly added dropwise under an ice bath. After the addition, reflux was performed at 65 ?? C. After 2 hours, the reaction system was cooled to room temperature, and methanol was evaporated to dryness under reduced pressure to obtain a colorless viscous substance.This colorless viscous substance was dissolved in 200 mL of THF, (Boc)2O (22.25 g, 101.95 mmol) was addedunder an ice bath, and triethylamine (14.13 mL, 101.95 mmol) was slowly added dropwise.After the addition was complete, the reaction was allowed to proceed at room temperature overnight.After completion of the reaction, the solvent was distilled off under reduced pressure.The residue was dissolved in 200 mL of dichloromethane.The organic phase was washed with water (200 mL * 2), saturated citric acid solution (200 mL * 2), saturated sodium bicarbonate solution (200 mL * 2), and saturated brine (200 mL * 2) in that order.The organic phase was dried over anhydrous Na2SO4. Thefiltrate was collected by filtration, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 4: 1 v / v) to give a colorless oily product (R)-N-Boc-glutamic acid-1,5-dimethyl ester (18.34 g, yield 98%)

(R)-N-Boc-glutamic acid-1,5-dimethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-N-Boc-glutamic acid-1,5-dimethyl ester Suppliers

Americas 1 China 287 Europe 1 Germany 5 India 11 Japan 3 United Kingdom 2 United States 17 Global 327
Nanjing Ally Chemical S&T Co., Ltd.
Tel
025-025-58367986 18913956109
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QQ:3209878052
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amy.xiang@ally-chem.com
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China
ProdList
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Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
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China
ProdList
42958
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64
Shanghai YuLue Chemical Co., Ltd.
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021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
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China
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JUYE XIANDAI fine chemistry Co.,Ltd
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13566887771
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8459310@qq.com
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China
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PharmaBlock Sciences (Nanjing),Inc.
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025-86918202 4000255188
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86-025-86918232
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sales@pharmablock.com
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China
ProdList
4986
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Alfa Aesar
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400-6106006
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021-67582001/03/05
Email
saleschina@alfa-asia.com
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China
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30123
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Sichuan Tongsheng Amino acids Co.,Ltd.
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0838-2809458 13350585791
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+86-838-2274207
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pharm@biots.cn
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China
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333
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Energy Chemical
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021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
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China
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44689
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Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
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66
Beijing Ouhe Technology Co., Ltd
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010-82967028 13552068683
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+86-10-82967029
Email
2355560935@qq.com
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China
ProdList
12390
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View Lastest Price from (R)-N-Boc-glutamic acid-1,5-dimethyl ester manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Boc-L-Glu(OMe)-OMe 59279-60-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98%min
Supply Ability
500kgs
Release date
2021-09-24
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-L-Glu(Ome)-Ome 59279-60-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2023-09-23
Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
(R)-N-Boc-glutamic acid-1,5-dimethyl ester 59279-60-6
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
99
Supply Ability
20tons
Release date
2024-02-06

59279-60-6, (R)-N-Boc-glutamic acid-1,5-dimethyl esterRelated Search:

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  • N-alpha-t-Butyloxycarbonyl-L-glutamic acid di-methyl ester
  • Dimethyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate
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  • u(Ome)-OMe
  • L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1,5-dimethyl ester
  • dimethyl(tert-butoxycarbonyl)-L-glutamate
  • imethyl(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate
  • Dimethyl N-Boc-L-glutamate
  • N-(tert-Butoxycarbonyl)-L-glutamic Acid Dimethyl Ester
  • Dimethyl (2S)-2-(tert-butoxycarbonylamino)pentanedioate
  • (R)-N-Boc-glutamic acid-1,5-dimethyl ester USP/EP/BP
  • Boc-Glu-OMe(OMe) USP/EP/BP
  • N-α-(t-Butoxycarbonyl)-L-glutamic acid α,γ-dimethyl ester
  • (R)-N-Boc-glutamic acid-1,5-dimethyl ester （PF-07321332 Paxlovid intermediate）
  • Dimethyl Boc-Glutamate
  • 59279-60-6---(R)-N-Boc-glutamic acid-1,5-dimethyl ester
  • 1,5-Dimethyl N-[(1,1-dimethylethoxy)carbonyl]-L-glutamate
  • N-Boc-L-glutamic acid 1,5-dimethyl
  • Dimethyl (S)-(N-tert-butoxycarbonyl)glutamate
  • (R)-N-Boc-glutamic acid-1,5-dimethyl este
  • BOC-L-glutamate dimethyl ester
  • Boc-L-Glu(Ome)-Ome-OH
  • N-tert-butoxycarbonyl-L-dimethyl glutamate
  • Dimethyl N-(tert-Butoxycarbonyl)-<small>L<
  • 59279-60-6
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  • 1