(R)-N-Boc-glutamic acid-1,5-dimethyl ester

ChemicalBook > CAS DataBase List > (R)-N-Boc-glutamic acid-1,5-dimethyl ester

(R)-N-Boc-glutamic acid-1,5-dimethyl ester

Product Name: (R)-N-Boc-glutamic acid-1,5-dimethyl ester
CAS No.: 59279-60-6
Chemical Name: (R)-N-Boc-glutamic acid-1,5-dimethyl ester
Synonyms: N-Boc-L-Glutamic acid dimethyl ester;BOC-GLU(OME)-OME;BOC-L-GLU(OME)-OME;Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate;BOC-GLU(OME)-OME 45G;BOC-L-GLUTAMIC ACID DIMETHYL ESTER;dimethyl(tert-butoxycarbonyl)-L-glutamate;(S)-diMethyl 2-(tert-butoxycarbonylaMino)pentanedioate;BOC-L-GLU(ME)-OME;Dimethyl (2S)-2-(tert-butoxycarbonylamino)pentanedioate
CBNumber: CB5853917
Molecular Formula: C12H21NO6
Formula Weight: 275.3
MOL File: 59279-60-6.mol

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(R)-N-Boc-glutamic acid-1,5-dimethyl ester Property

Melting point:: 43.0 to 47.0 °C
Boiling point:: 370.9±32.0 °C(Predicted)
Density: 1.117±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly)
pka: 10.86±0.46(Predicted)
form: Liquid
color: Colorless to pale yellow
InChI: InChI=1S/C12H21NO6/c1-12(2,3)19-11(16)13-8(10(15)18-5)6-7-9(14)17-4/h8H,6-7H2,1-5H3,(H,13,16)/t8-/m0/s1
InChIKey: QNSPKWUAZQIIGZ-QMMMGPOBSA-N
SMILES: C(OC)(=O)[C@H](CCC(OC)=O)NC(OC(C)(C)C)=O
CAS DataBase Reference: 59279-60-6(CAS DataBase Reference)

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Safety

HS Code: 2922420090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4536
Product name: Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $30
Updated: 2024/03/01

TCI Chemical

Product number: D4536
Product name: Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate
Purity: >98.0%(HPLC)(N)
Packaging: 5g
Price: $87
Updated: 2024/03/01

Alfa Aesar

Product number: H62056
Product name: N-Boc-L-glutamic acid 1,5-dimethyl ester, 97%
Packaging: 5g
Price: $62.65
Updated: 2024/03/01

Alfa Aesar

Product number: H62056
Product name: N-Boc-L-glutamic acid 1,5-dimethyl ester, 97%
Packaging: 25g
Price: $260.65
Updated: 2024/03/01

TRC

Product number: B600185
Product name: N-Boc-L-glutamicAcid1,5-DimethylEster
Packaging: 5g
Price: $80
Updated: 2021/12/16

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(R)-N-Boc-glutamic acid-1,5-dimethyl ester Chemical Properties,Usage,Production

Uses

(R)-N-Boc-glutamic acid-1,5-dimethyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development and chemical production processes.

Synthesis

L-glutamic acid (10.0 g, 67.97 mmol) was dissolved in 200 mL of methanol, and SOCl2(10.85 mL, 149.53 mmol)was slowly added dropwise under an ice bath. After the addition, reflux was performed at 65 ?? C. After 2 hours, the reaction system was cooled to room temperature, and methanol was evaporated to dryness under reduced pressure to obtain a colorless viscous substance.This colorless viscous substance was dissolved in 200 mL of THF, (Boc)2O (22.25 g, 101.95 mmol) was addedunder an ice bath, and triethylamine (14.13 mL, 101.95 mmol) was slowly added dropwise.After the addition was complete, the reaction was allowed to proceed at room temperature overnight.After completion of the reaction, the solvent was distilled off under reduced pressure.The residue was dissolved in 200 mL of dichloromethane.The organic phase was washed with water (200 mL * 2), saturated citric acid solution (200 mL * 2), saturated sodium bicarbonate solution (200 mL * 2), and saturated brine (200 mL * 2) in that order.The organic phase was dried over anhydrous Na2SO4. Thefiltrate was collected by filtration, and the solvent was evaporated under reduced pressure. The residue was purified by column chromatography (petroleum ether: ethyl acetate = 4: 1 v / v) to give a colorless oily product (R)-N-Boc-glutamic acid-1,5-dimethyl ester (18.34 g, yield 98%)

(R)-N-Boc-glutamic acid-1,5-dimethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (R)-N-Boc-glutamic acid-1,5-dimethyl ester manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Glu(Ome)-Ome 59279-60-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-23

AstaTech(Chengdu) Biopharmaceutical Corp.

Product: (R)-N-Boc-glutamic acid-1,5-dimethyl ester
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0% HPLC
Supply Ability: 1-5tons/year
Release date: 2022-01-07

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: (R)-N-Boc-glutamic acid-1,5-dimethyl ester 59279-60-6
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99
Supply Ability: 20tons
Release date: 2024-02-06

59279-60-6, (R)-N-Boc-glutamic acid-1,5-dimethyl esterRelated Search:

Dacthal Dimethyl fumarate Dimethyl sulfide Dimethyl oxalate N,N-Dimethylformamide N-Carbobenzyloxyglycine Dimethyl sulfate L-Glutamic acid ETHANE Dimethyl ether Dimethyl carbonate Dimethyl adipate Dimethyl malonate Dimethyl sulfoxide Dimethyl sebacate Dimethyl phthalate Boc-L-Glutamic acid 5-benzylester Glutamic acid

BOC-L-GLU(OME)-OME

BOC-L-GLUTAMIC ACID DIMETHYL ESTER

1,5-dimethyl (2S)-2-{[(tert-butoxy)carbonyl]amino}pentanedioate

(R)-N-Boc-glutamic acid-1，5-dinethyl ester

BOC-GLU(OME)-OME

Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate

BOC-GLU(OME)-OME 45G

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-GLUTAMIC ACID DI-METHYL DIESTER

N-ALPHA-T-BUTYLOXYCARBONYL-L-GLUTAMIC ACID DIMETHYL DIESTER

N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID ALPHA, GAMMA-DIMETHYL ESTER

N-Boc-L-Glutamic acid dimethyl ester

(R)-N-BOC-GLUTAMIC ACID-1,5-DIMETHYL ESTER

BOC-L-GLU(ME)-OME

(Tert-Butoxy)Carbonyl Glu(OMe)-OMe (Syrup)

(S)-diMethyl 2-(tert-butoxycarbonylaMino)pentanedioate

(S)-2-tert-ButoxycarbonylaMinopentanedioic acid diMethyl ester

Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate

N-alpha-t-Butyloxycarbonyl-L-glutamic acid di-methyl ester

Dimethyl (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate

N-Boc-L-GlutaMic Acid diMethyl ester/(S)-2-tert-ButoxycarbonylaMino-pentanedioic acid diMethyl ester (S)-2-tert-ButoxycarbonylaMino-pentanedioic acid diMethyl ester

N-Boc-L-glutaMic acid 1,5-diMethyl ester, 97%

Dimethyl N-(tert-Butoxycarbonyl)-L-glutamate &gt

u(Ome)-OMe

L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1,5-dimethyl ester

dimethyl(tert-butoxycarbonyl)-L-glutamate

imethyl(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]pentanedioate

Dimethyl N-Boc-L-glutamate

N-(tert-Butoxycarbonyl)-L-glutamic Acid Dimethyl Ester

Dimethyl (2S)-2-(tert-butoxycarbonylamino)pentanedioate

(R)-N-Boc-glutamic acid-1,5-dimethyl ester USP/EP/BP

Boc-Glu-OMe(OMe) USP/EP/BP

N-α-(t-Butoxycarbonyl)-L-glutamic acid α,γ-dimethyl ester

(R)-N-Boc-glutamic acid-1,5-dimethyl ester （PF-07321332 Paxlovid intermediate）

Dimethyl Boc-Glutamate

59279-60-6---(R)-N-Boc-glutamic acid-1,5-dimethyl ester

1,5-Dimethyl N-[(1,1-dimethylethoxy)carbonyl]-L-glutamate

N-Boc-L-glutamic acid 1,5-dimethyl

Dimethyl (S)-(N-tert-butoxycarbonyl)glutamate

(R)-N-Boc-glutamic acid-1,5-dimethyl este

59279-60-6

59579-60-6

52979-60-6