Boc-L-Glutamic acid 5-benzylester

Product Name: Boc-L-Glutamic acid 5-benzylester
CAS No.: 13574-13-5
Chemical Name: Boc-L-Glutamic acid 5-benzylester
Synonyms: BOC-GLU(OBZL)-OH;(S)-5-(benzyloxy)-2-((tert-butoxycarbonyl)aMino)-5-oxopentanoic acid;BOC-L-GLU(OBZL)-OH;BOC-L-GLUTAMIC ACID 5-BENZYL ESTER;Boc-Glu(Bzl)-OH;BOC-CLU(OBZL)-OH;BOC-L-GLU(BZL)-OH;Boc-Glu(Obzl)-OH ,98%;BOC-GLUTAMIC ACID(OBZL)-OH;BOC-L-GLUTAMIC ACID (OBZL)
CBNumber: CB6748119
Molecular Formula: C17H23NO6
Formula Weight: 337.37
MOL File: 13574-13-5.mol

More

Less

Boc-L-Glutamic acid 5-benzylester Property

Melting point:: 69-71 °C
alpha: -16 º (c=2, DMF)
Boiling point:: 473.68°C (rough estimate)
Density: 1.1452 (rough estimate)
refractive index: -16.5 ° (C=2, DMF)
storage temp.: 2-8°C
solubility: Soluble in N,N- Dimethyl formamide.
pka: 3.81±0.10(Predicted)
form: powder to crystal
color: White to Almost white
optical activity: [α]20/D 5.5±0.5°, c = 1% in acetic acid
BRN: 2226572
Sequence: Boc-Glu(OBzl)
CAS DataBase Reference: 13574-13-5(CAS DataBase Reference)
EPA Substance Registry System: L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-(phenylmethyl) ester (13574-13-5)
CAS Number Unlabeled: 56-86-0
CAS Number Unlabeled: 13574-13-5

More

Less

Safety

Safety Statements: 22-24/25
WGK Germany: 3
TSCA: Yes
HS Code: 29242990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.53010
Product name: Boc-Glu(OBzl)-OH
Purity: (cryst) Novabiochem®
Packaging: 25 g
Price: $112
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53010
Product name: Boc-Glu(OBzl)-OH
Purity: (cryst) Novabiochem®
Packaging: 100 g
Price: $286
Updated: 2025/07/31

Sigma-Aldrich

Product number: 8.53010
Product name: Boc-Glu(OBzl)-OH
Purity: (cryst) Novabiochem®
Packaging: 1 kg
Price: $1950
Updated: 2025/07/31

Sigma-Aldrich

Product number: 15418
Product name: Boc-Glu(OBzl)-OH
Purity: ≥98.0% (T)
Packaging: 25g
Price: $89.3
Updated: 2025/07/31

TCI Chemical

Product number: B1633
Product name: 5-Benzyl N-(tert-Butoxycarbonyl)-L-glutamate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $36
Updated: 2025/07/31

More

Less

Boc-L-Glutamic acid 5-benzylester Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

N-Boc-L-glutamic acid 5-benzyl ester is used as a pharmaceutical intermediate.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

1676-73-9

24424-99-5

13574-13-5

The general procedure for the synthesis of Boc-L-glutamic acid-O-benzyl from L-glutamic acid-5-benzyl ester and di-tert-butyl dicarbonate is as follows: Example 28 - Preparation of Formula 125-Compound 28a-Intermediate B: (S)-5-(benzyloxy)-2-(tert-butoxycarbonyl)-5-oxopentanoic acid 1. Compound A (5.0 g, 21.1 mmol) was dissolved in a solvent mixture of dioxane and water (1:1, 40 mL) and cooled at 0°C. 2. Boc2O (5.06 g, 23.1 mmol) was added to the above solution, followed by stirring the reaction mixture at room temperature overnight. 3. After completion of the reaction, the solvent was removed by distillation under reduced pressure. 4. The residue was diluted with water (30 mL) and alkalized with Na2CO3 (0.7 g). 5. The aqueous layer was washed with EtOAc (3 x 20 mL). 6. The pH of the aqueous layer was adjusted to 2-3 with 5 M aqueous HCl followed by extraction with EtOAc (4 x 50 mL). 7. The organic extracts were combined, washed with brine and dried with Na2SO4. 8. The solvent was removed under pressure to give (S)-5-(benzyloxy)-2-(tert-butoxycarbonyl)-5-oxovaleric acid (7.1 g, 100%) as a viscous colorless oil. Product characterization: LC-MS (Agilent): retention time (Rt) 3.40 min; m/z calculated value C17H23NO6 [M + Na]+ 360.15, measured value 360.1.

References

[1] Patent: WO2012/63085, 2012, A2. Location in patent: Page/Page column 115
[2] Patent: US2013/225594, 2013, A1. Location in patent: Paragraph 0425; 0426
[3] Synthetic Communications, 1990, vol. 20, # 15, p. 2235 - 2249
[4] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 2, p. 501 - 517
[5] Organic Syntheses, 1985, vol. 63, p. 160 - 160

Boc-L-Glutamic acid 5-benzylester Preparation Products And Raw materials

Raw materials

tert-butoxycarbonyl-L-glutamic acid

Preparation Products

More

Less

Boc-L-Glutamic acid 5-benzylester Suppliers

Americas 1 Belgium 1 China 285 Europe 3 France 1 Germany 6 Hungary 1 India 15 Italy 2 Japan 7 South Korea 1 Switzerland 5 United Kingdom 11 United States 51 Global 390

Chengdu Forest Science and Technology Development Co., Ltd.

Tel: 18030648795
Fax: 028-61777050
Email: sales@cdforestchem.com
Country: China
ProdList: 1998
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

More

Less

View Lastest Price from Boc-L-Glutamic acid 5-benzylester manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-Glu(OBzl)-OH 13574-13-5
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 500kgs
Release date: 2021-09-24

Honest Joy Holdings Limited

Product: Boc-glu(obzl)-oh 13574-13-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.3%
Supply Ability: 100 tons
Release date: 2022-01-25

Career Henan Chemical Co

Product: Boc-L-Glutamic acid 5-benzylester 13574-13-5
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

13574-13-5, Boc-L-Glutamic acid 5-benzylesterRelated Search:

4-tert-Butylbenzyl chloride Nequinate tert-Butyl acetate Benzyl chloride Benzyl alcohol Benzyl isocyanate L-Glutamic acid tert-Butyl peroxyacetate CARBONYL SULFIDE tert-Butanol Folic acid Benzyl benzoate PYRAZOPHOS Benzyl nicotinate 1,1'-Carbonyldiimidazole Trimethoprim (R)-N-Boc-glutamic acid-1,5-dimethyl ester Boc-D-Valine

n-[(1,1-dimethylethoxy)carbonyl]-l-glutamicaci5-(phenylmethyl)ester

BOC-L-GLUTAMIC ACID-Y-BENZYLESTER

N-t-BOC-L-glutamic acid 5-benzyl ester

(2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-5-oxo-5-(phenylmethoxy)pentanoic acid

L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-(phenylmethyl) ester

N-tert-Butoxycarbonyl-g-benzyl-L-glutamic acid

N-(tert-Butoxycarbonyl)-L-glutamic acid 5-benzyl ester ,98%

(4S)-4-(tert-Butoxycarbonylamino)glutaric acid 1-benzyl ester

5-Oxo-5-(benzyloxy)-N-(tert-butoxycarbonyl)-L-norvaline

N-(tert-Butoxycarbonyl)-5-oxo-5-(benzyloxy)-L-norvaline

N-(tert-Butyloxycarbonyl)-L-glutamic acid 5-benzyl ester

N-[(1,1-Dimethylethoxy)carbonyl]-L-glutamic acid 5-(phenylmethyl) ester

BOC-L-Glutamic acid 5-benzylester,99%

Boc-Glu(Obzl)-OH ,98%

Boc-Glu(OBzl)-OH Boc-L-glutaMic acid γ-benzyl ester

5-Benzyl N-Boc-L-glutamate N-(tert-Butoxycarbonyl)-L-glutamic Acid 5-Benzyl Ester N-Boc-L-glutamic Acid 5-Benzyl Ester Boc-Glu(OBzl)-OH

(2S)-5-(benzyloxy)-2-[(tert-butoxycarbonyl)aMino]-5-oxopentanoic acid

(S)-5-(benzyloxy)-2-((tert-butoxycarbonyl)aMino)-5-oxopentanoic acid

T-BUTYLOXYCARBONYL-L-GLUTAMIC ACID GAMMA-BENZYL ESTER

TBOC-L-GLUTAMIC ACID (OBZL)

N-BOC-L-GLUTAMIC ACID 5-BENZYL ESTER

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-GLUTAMIC ACID GAMMA-BENZYL ESTER

N-ALPHA-TERT-BOC-L-GLUTAMIC-GAMMA-BENZYL ESTER

N-ALPHA-T-BOC-L-GLUTAMIC ACID GAMMA-BENZYL ESTER

N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID GAMMA-BENZYL ESTER

N-T-BUTOXYCARBONYL-L-GLUTAMIC ACID 5-BENZYL ESTER

N-T-BOC-L-GLUTAMIC ACID GAMMA-BENZYL ESTER

N-(TERT-BUTOXYCARBONYL)-L-GLUTAMIC ACID 5-BENZYL ESTER

BOC-GLUTAMIC ACID(OBZL)-OH

BOC-GLU(OBZL)-OH

BOC-L-GLUTAMIC ACID GAMMA-BENZYL ESTER

BOC-L-GLUTAMIC ACID (OBZL)

BOC-L-GLUTAMIC ACID G-BENZYL ESTER

BOC-L-GLUTAMIC ACID 5-BENZYL ESTER

BOC-L-GLU(BZL)-OH

BOC-L-GLU(OBZL)-OH

5-BENZYL N-(TERT-BUTOXYCARBONYL)-L-GLUTAMATE

5-BENZYL N-BOC-L-GLUTAMATE

Boc-Glu(OBzl)-OH >=98.0% (T)

Boc-L-glutamic acid γ-benzyl ester≥ 98% (HPLC)

N-alpha-t-BOC-L-glutamic-gamma-benzyl ester

5-benzyl N-[(1,1-dimethylethoxy)carbonyl]-L-glutamate

N-T-BOC-L-GLUTAMIC ACID GAMMA-BENZYLESTE R FREE ACI

N-ALPHA-(TERT-BUTOXYCARBONYL)-L-GLUTAMIC ACID 5-BENZYL ESTER

L-Glutamic Acid-13C2-1,2-N-t-BOC, y-Benzyl Ester

BOC-CLU(OBZL)-OH

N-ALPHA-T-BUTYLOXYCARBONYL-L-GLUTAMIC ACID GAMMA-BENZYL ESTER

(Tert-Butoxy)Carbonyl Glu(OBzl)-OH

N-ALPHA-TERT-BUTYLOXYCARBONYL-L-GL

N-α-tert-BOC-L-glutamic-gamma-benzyl ester

5-Benzyl N-(tert-Butoxycarbonyl)-L-glutamate &gt

L-GLUTAMIC ACID-N-T-BOC, GAMMA-BENZYL-ESTER (1,2-13C2, 99%)

Boc-L-Glutamic acid 5-benzylester USP/EP/BP

Boc-Glu(Bzl)-OH

Boc-L-glutamic acid 5-benzyl ester, 98%+

BOC-L-Glutamic Acid-5-Benzyl Ester extrapure, 98%

5-Benzyl N-(tert-butoxycarbonyl)-L-glutamate/N-tert- Butoxycarbonyl-L-glutamic acid 5-benzyl ester

5-(Phenylmethyl) hydrogen N-[(1,1-dimethylethoxy)carbonyl]-L-glutamate