ChemicalBook > CAS DataBase List > Boc-L-Pyroglutamic acid methyl ester

Boc-L-Pyroglutamic acid methyl ester

Product Name
Boc-L-Pyroglutamic acid methyl ester
CAS No.
108963-96-8
Chemical Name
Boc-L-Pyroglutamic acid methyl ester
Synonyms
(S)-1-tert-Butyl 2-Methyl 5-oxopyrrolidine-1,2-dicarboxylate;BOC-PYR-OME;(S)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE;1-tert-Butyl 2-Methyl (2S)-5-Oxopyrrolidine-1,2-dicarboxylate;utamate;Boc-pGlu-OMe;BOC-L-Pyr.Ome;Boc-Pyr-OMe 99%;Boc-L-Pyroglutamic a;Methyl (L)-N-Boc-pyroglu
CBNumber
CB7717837
Molecular Formula
C11H17NO5
Formula Weight
243.26
MOL File
108963-96-8.mol
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Boc-L-Pyroglutamic acid methyl ester Property

Melting point:
68-72 °C 69-74 °C
Boiling point:
361.6±35.0 °C(Predicted)
Density 
1.209±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in dichloromethane.
pka
-4.28±0.40(Predicted)
form 
powder to crystal
color 
White to Almost white
optical activity
[α]22/D 32.0°, c = 0.5 in chloroform &_& [α]22/D -32°, c = 0.5% in chloroform
InChI
InChI=1S/C11H17NO5/c1-11(2,3)17-10(15)12-7(9(14)16-4)5-6-8(12)13/h7H,5-6H2,1-4H3/t7-/m0/s1
InChIKey
FNTAOUUEQHKLIU-ZETCQYMHSA-N
SMILES
N1(C(OC(C)(C)C)=O)C(=O)CC[C@H]1C(OC)=O
CAS DataBase Reference
108963-96-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,N
Risk Statements 
36-43-50
Safety Statements 
26-36/37-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HazardClass 
9
HS Code 
29337900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
757497
Product name
Boc-Pyr-OMe
Purity
97%
Packaging
1g
Price
$33
Updated
2023/06/20
Sigma-Aldrich
Product number
738182
Product name
Methyl (S)-Boc-5-pyrrolidone-2-carboxylate
Purity
97%
Packaging
1g
Price
$40.4
Updated
2023/01/07
TCI Chemical
Product number
M2803
Product name
Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate
Purity
>98.0%(GC)
Packaging
5g
Price
$69
Updated
2025/07/31
TCI Chemical
Product number
M2803
Product name
Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate
Purity
>98.0%(GC)
Packaging
25g
Price
$237
Updated
2025/07/31
TRC
Product number
M294429
Product name
Methyl(2S)-1-(tert-butoxycarbonyl)pyroglutamate
Packaging
5g
Price
$115
Updated
2021/12/16
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Boc-L-Pyroglutamic acid methyl ester Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

Methyl (S)-1-Boc-5-oxopyrrolidine-2-carboxylate in medicine, pharmacy, cosmetics, and industrial, artificial flavoring and fragrance agents

Synthesis

67-56-1

24424-99-5

98-79-3

108963-96-8

(1) Synthesis of (2S)-5-oxopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (Compound 3): L-pyroglutamic acid (15.0 g) was suspended in methanol (60.0 mL), and thionyl chloride (27.6 g) was slowly added with stirring at a temperature lower than 30°C. The reaction was completed after 1 hour by HPLC. After 1 hr of reaction, HPLC monitoring showed completion of the reaction. The solvent was removed by distillation under reduced pressure and the residue was dissolved in ethyl acetate (200 mL). Triethylamine (13.5 g) was slowly added at a temperature below 30 °C, followed by filtration of the mixture. To the filtrate was added DMAP (1.5 g) in a single addition, followed by di-tert-butyl dicarbonate (Boc2O, 27.8 g) at a temperature below 30 °C. After HPLC monitoring showed the reaction to be complete, the mixture was cooled to 0 °C and 1N HCl (13.0 mL) was added and stirred at a temperature below 30 °C for 10 min. The organic layer was separated, washed with H2O (20.0 mL) and the solvent was evaporated under reduced pressure. To the resulting residue was added tert-butyl methyl ether (27.0 mL) and cooled to 0°C with stirring. The slowly precipitated crystals were filtered to give compound 3 (21.9 g, 77.3% yield).

References

[1] Patent: WO2010/9014, 2010, A2. Location in patent: Page/Page column 6
[2] Patent: CN106336371, 2017, A. Location in patent: Paragraph 0050; 0051

Boc-L-Pyroglutamic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Boc-L-Pyroglutamic acid methyl ester manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
Boc-L-Pyroglutamic acid methyl ester 108963-96-8
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg
Release date
2025-05-07
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Boc-L-Pyroglutamic acid methyl ester 108963-96-8
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500kg/month
Release date
2021-07-22
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Boc-L-Pyroglutamic acid methyl ester 108963-96-8
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T
Release date
2023-11-21

108963-96-8, Boc-L-Pyroglutamic acid methyl esterRelated Search:

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  • Amino Acids and Derivatives
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  • AMINOACIDS DERIVATIVES