Boc-L-Pyroglutamic acid methyl ester

Product Name: Boc-L-Pyroglutamic acid methyl ester
CAS No.: 108963-96-8
Chemical Name: Boc-L-Pyroglutamic acid methyl ester
Synonyms: (S)-1-tert-Butyl 2-Methyl 5-oxopyrrolidine-1,2-dicarboxylate;BOC-PYR-OME;(S)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE;1-tert-Butyl 2-Methyl (2S)-5-Oxopyrrolidine-1,2-dicarboxylate;utamate;Boc-pGlu-OMe;BOC-L-Pyr.Ome;Boc-Pyr-OMe 99%;Boc-L-Pyroglutamic a;Methyl (L)-N-Boc-pyroglu
CBNumber: CB7717837
Molecular Formula: C11H17NO5
Formula Weight: 243.26
MOL File: 108963-96-8.mol

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Boc-L-Pyroglutamic acid methyl ester Property

Melting point:: 68-72 °C 69-74 °C
Boiling point:: 361.6±35.0 °C(Predicted)
Density: 1.209±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Soluble in dichloromethane.
pka: -4.28±0.40(Predicted)
form: powder to crystal
color: White to Almost white
optical activity: [α]22/D 32.0°, c = 0.5 in chloroform &_& [α]22/D -32°, c = 0.5% in chloroform
InChI: InChI=1S/C11H17NO5/c1-11(2,3)17-10(15)12-7(9(14)16-4)5-6-8(12)13/h7H,5-6H2,1-4H3/t7-/m0/s1
InChIKey: FNTAOUUEQHKLIU-ZETCQYMHSA-N
SMILES: N1(C(OC(C)(C)C)=O)C(=O)CC[C@H]1C(OC)=O
CAS DataBase Reference: 108963-96-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xn,N
Risk Statements: 36-43-50
Safety Statements: 26-36/37-61
RIDADR: UN 3077 9 / PGIII
WGK Germany: 3
HazardClass: 9
HS Code: 29337900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 757497
Product name: Boc-Pyr-OMe
Purity: 97%
Packaging: 1g
Price: $33
Updated: 2023/06/20

Sigma-Aldrich

Product number: 738182
Product name: Methyl (S)-Boc-5-pyrrolidone-2-carboxylate
Purity: 97%
Packaging: 1g
Price: $40.4
Updated: 2023/01/07

TCI Chemical

Product number: M2803
Product name: Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate
Purity: >98.0%(GC)
Packaging: 5g
Price: $69
Updated: 2025/07/31

TCI Chemical

Product number: M2803
Product name: Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate
Purity: >98.0%(GC)
Packaging: 25g
Price: $237
Updated: 2025/07/31

TRC

Product number: M294429
Product name: Methyl(2S)-1-(tert-butoxycarbonyl)pyroglutamate
Packaging: 1g
Price: $70
Updated: 2021/12/16

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Boc-L-Pyroglutamic acid methyl ester Chemical Properties,Usage,Production

Chemical Properties

Light Yellow Solid

Uses

Methyl (S)-1-Boc-5-oxopyrrolidine-2-carboxylate in medicine, pharmacy, cosmetics, and industrial, artificial flavoring and fragrance agents

Synthesis

67-56-1

24424-99-5

98-79-3

108963-96-8

(1) Synthesis of (2S)-5-oxopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (Compound 3): L-pyroglutamic acid (15.0 g) was suspended in methanol (60.0 mL), and thionyl chloride (27.6 g) was slowly added with stirring at a temperature lower than 30°C. The reaction was completed after 1 hour by HPLC. After 1 hr of reaction, HPLC monitoring showed completion of the reaction. The solvent was removed by distillation under reduced pressure and the residue was dissolved in ethyl acetate (200 mL). Triethylamine (13.5 g) was slowly added at a temperature below 30 °C, followed by filtration of the mixture. To the filtrate was added DMAP (1.5 g) in a single addition, followed by di-tert-butyl dicarbonate (Boc2O, 27.8 g) at a temperature below 30 °C. After HPLC monitoring showed the reaction to be complete, the mixture was cooled to 0 °C and 1N HCl (13.0 mL) was added and stirred at a temperature below 30 °C for 10 min. The organic layer was separated, washed with H2O (20.0 mL) and the solvent was evaporated under reduced pressure. To the resulting residue was added tert-butyl methyl ether (27.0 mL) and cooled to 0°C with stirring. The slowly precipitated crystals were filtered to give compound 3 (21.9 g, 77.3% yield).

References

[1] Patent: WO2010/9014, 2010, A2. Location in patent: Page/Page column 6
[2] Patent: CN106336371, 2017, A. Location in patent: Paragraph 0050; 0051

Boc-L-Pyroglutamic acid methyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Boc-L-Pyroglutamic acid methyl ester Suppliers

Americas 1 Canada 1 China 283 Europe 2 France 2 Germany 2 India 19 Japan 1 The Netherlands 1 United Kingdom 6 United States 19 Global 337

GLR Innovations

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View Lastest Price from Boc-L-Pyroglutamic acid methyl ester manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Boc-L-Pyroglutamic acid methyl ester 108963-96-8
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-05-07

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-L-Pyroglutamic acid methyl ester 108963-96-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500kg/month
Release date: 2021-07-22

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Pyroglutamic acid methyl ester 108963-96-8
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T
Release date: 2023-11-21

108963-96-8, Boc-L-Pyroglutamic acid methyl esterRelated Search:

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(S)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE

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BOC-L-PYROGLUTAMIC ACID METHYL ESTER

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(S)-N-(tert-butoxycarbonyl)pyroglutaMate

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N-Boc-(S)-2-pyrrolidone-5-carboxylic acid methyl ester

N-Boc-5-oxo-L-proline methyl ester

N-Boc-L-Pyroglutamic acid methyl ester

(2S)-5-oxo-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester

Methyl N-(tert-Butoxycarbonyl)-L-pyroglutamate

1,2-Pyrrolidinedicarboxylic acid, 5-oxo-, 1-(1,1-diMethylethyl) 2-Methyl ester, (2S)-

Methyl (S)-Boc-5-pyrrolidone-2-carboxylate

(S)-1-tert-Butyl 2-Methyl 5-oxopyrrolidine-1,2-dicarboxylate

Methyl (S)-1-Boc-5-oxopyrrolidine-2-carboxylate, 98%

BOC-L-Pyr.Ome

utamate

Boc-l-methyl pyroglutamate

Methyl(S)-1-Boc-5-oxopyrrolidine-2-carboxylate,98%

(S)-1-(tert-Butoxycarbonyl)-5-oxopyrrolidine-2-carboxylic Acid Methyl Ester

Methyl (S)-1-(tert-Butoxycarbonyl)-5-oxopyrrolidine-2-carboxylate

Methyl N-Boc-L-pyroglutamate

N-Boc-L-pyroglutamic Acid M

Boc-L-Pyroglutamic acid methyl ester USP/EP/BP

Methyl t-butoxycarbonyl-l-pyroglutamate

1-O-tert-butyl 2-O-methyl (2S)-5-oxopyrrolidine-1,2-dicarboxylate

TIANFU CHEM 108963-96-8 Boc-L-Pyroglutamic acid methyl ester

1-(tert-Butyl) 2-methyl (S)-5-oxopyrrolidine-1,2-dicarboxylate

Boc-L-Pyroglutamic methyl ester

Boc-L-Pyroglutamic acid methyl ester,97%

Methyl (<i>S</i>)-Boc-5-pyrrolidone-2-carboxylate

Methyl L-N-Boc-Pyroglutamate, CAS 108963-96-8

Boc-Pyr-OMe 99%

108963-96-8

Chiral Reagents

Pyroglutamic acid [Pyr, pGu]

Amino Acids and Derivatives

pharmacetical

AMINOACIDS DERIVATIVES