Amlodipine maleate

Product Name: Amlodipine maleate
CAS No.: 88150-47-4
Chemical Name: Amlodipine maleate
Synonyms: AMLODIPINE MALEATE;Amlodipine IH Impurity A;Amlodipine maleate USP/EP/BP;Amlodipine maleate - Bio-X ?;AMLODIPINE MALEATE MM STANDARD;Amlodipine maleate (crystalline);Amlodipine maleate, 10 mM in DMSO;AmlodipineMaleateC20H25C1N205.C4H404;3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5;3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate Maleate
CBNumber: CB8267687
Molecular Formula: C30H35ClN2O12S
Formula Weight: 524.95
MOL File: 88150-47-4.mol

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Amlodipine maleate Property

Melting point:: 178-179°
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Off-White to Pale Yellow
Stability:: Light Sensitive
InChIKey: TZNOWAJJWCGILX-BTJKTKAUSA-N
SMILES: C1(C2=CC=CC=C2Cl)C(=C(NC(COCCN)=C1C(=O)OCC)C)C(=O)OC.C(/C(=O)O)=C/C(=O)O
CAS DataBase Reference: 88150-47-4(CAS DataBase Reference)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A633595
Product name: AmlodipineMaleate
Packaging: 500mg
Price: $145
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA61537
Product name: Amlodipine maleate
Packaging: 1g
Price: $60
Updated: 2021/12/16

ApexBio Technology

Product number: C6705
Product name: Amlodipinemaleate
Packaging: 1g
Price: $70
Updated: 2021/12/16

ChemScene

Product number: CS-3987
Product name: Amlodipine(maleate)
Purity: 99.85%
Packaging: 1g
Price: $84
Updated: 2021/12/16

AK Scientific

Product number: J54831
Product name: Amlodipinemaleate
Packaging: 1g
Price: $40
Updated: 2021/12/16

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Amlodipine maleate Chemical Properties,Usage,Production

Uses

Anti-anginal; antihypertensive.

brand name

Amvaz (Dr. Reddy’s).

Synthesis

88150-62-3

110-16-7

88150-47-4

1. 290 kg of methylamine solution was added to the reactor, 59 kg of methyl 4-(2-chlorophenyl)-2-(((2-(1,3-dioxoisoindolin-2-yl)ethoxy)methyl)-6-methyl-1,4-dihydropyridine-3-carboxylic acid ethyl ester-5-carboxylate (o-benzoylcarbamodiphenyl) was added with stirring, and the reaction was carried out with stirring for 20 hrs. at 25 °C. After completion of the reaction, the reaction was cooled to 20°C and the reaction mixture was filtered. The filtrate was washed with potable water until the pH of the wash water was ≤ 10, followed by rinsing the filtrate with purified water. The filtrate residue was dried at 60°C until the moisture content was ≤1.5%, cooled at room temperature and discharged to obtain amlodipine. 2. 10 g of amlodipine and 100 ml of water were added to a 250 ml aubergine flask and stirred at room temperature. 3.9 g of maleic acid was dissolved in 40 ml of water and slowly added dropwise to the amlodipine solution at a constant temperature of 30°C. The solution was then stirred at room temperature. After completion of the dropwise addition, stirring was continued for 4 h. Subsequently, filtration was carried out. The filter cake was washed with water twice, and the filter cake was dried under vacuum at 65 °C for more than 8 h. A white amlodipine maleate crude product was obtained with 91% yield and 99.2% purity. 3. 10 g of crude amlodipine maleate was taken and added to a 250 ml aubergine bottle, 80 ml of methanol was added and heated to 60 °C with stirring until completely dissolved. Subsequently cooled to 50°C, 1 g of activated carbon was added, stirred well and then stirred at 65°C for 30 minutes. The activated carbon was removed by hot filtration and the aubergine bottle was washed with 20 ml of methanol. The filtrate was distilled under reduced pressure, concentrated to 40 ml and then 120 ml of ethyl acetate was added and azeotropic distillation was carried out to concentrate the volume to 50 ml. After cooling at room temperature, it was further cooled and stirred at 0°C for 2 hrs, filtered, dried under reduced pressure to give amlodipine maleate in 91.5% yield and 99.5% purity.

References

[1] Patent: CN108358833, 2018, A. Location in patent: Paragraph 0013; 0023-0025
[2] Patent: US4572909, 1986, A

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View Lastest Price from Amlodipine maleate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Amlodipine maleate 88150-47-4
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-09-09

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Amlodipine maleate 88150-47-4
Price: US $79.00-38.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-11-25

Hebei Chuanghai Biotechnology Co., Ltd

Product: Amlodipine maleate 88150-47-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-11

88150-47-4, Amlodipine maleateRelated Search:

AMlodipine IMpurity F Maleate Kresoxim-methyl Disodium fumarate Dihydromyrcenol Basic Violet 1 Acetonitrile Methanol (S)-Amlodipine Methylparaben Enalapril maleate Paraquat dichloride Methyl acetate Methyl acrylate AMlodipine IMpurity E Maleate Methyl diethyl 4-(2-chlorophenyl)-2-((2-(1,3-dioxoisoindolin-2-yl)ethoxy)Methyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate AMLODIPINE-D4 MALEIC ACID SALT (R)-Amlodipine-d4

2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester (z)-2-butenedioate

AMLODIPINE MALEATE MM STANDARD

AmlodipineMaleateC20H25C1N205.C4H404

AMLODIPINE MALEATE

3-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5

2-[(2-AMINOETHOXY)METHYL)-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5 PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER B

3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate Maleate

Amlodipine IH Impurity A

Amlodipine maleate (crystalline)

((2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6- methyl-1, 4-dihydropyridine-3, 5-dicarboxylic acid 3- ethyl ester 5-methyl ester)

Amlodipine maleate USP/EP/BP

Amlodipine D4 MaleateQ: What is Amlodipine D4 Maleate Q: What is the CAS Number of Amlodipine D4 Maleate Q: What is the storage condition of Amlodipine D4 Maleate Q: What are the applications of Amlodipine D4 Maleate

Amlodipine MaleateQ: What is Amlodipine Maleate Q: What is the CAS Number of Amlodipine Maleate Q: What is the storage condition of Amlodipine Maleate Q: What are the applications of Amlodipine Maleate

Amlodipine 3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl) 6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate Maleate

Amlodipine maleate, 10 mM in DMSO

Amlodipine maleate - Bio-X ?

88150-47-4

C20H25ClN2O5C4H4O4

C24H29ClN2O9

C20H25ClN2O5C4H4O4C24H29ClN2O9

C20H25ClN2O9C4H4O4

C20H25ClN2O5C4H4O4C

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