6-[(1-NaphthalenylMethyl)thio]-9H-purine
- Product Name
- 6-[(1-NaphthalenylMethyl)thio]-9H-purine
- CAS No.
- 313984-77-9
- Chemical Name
- 6-[(1-NaphthalenylMethyl)thio]-9H-purine
- Synonyms
- PU 02;PU-02; PU02;6-[(1-NaphthalenylMethyl)thio]-9H-purine;6-((Naphthalen-1-ylmethyl)thio)-7H-purine;9H-Purine, 6-[(1-naphthalenylmethyl)thio]-;6-(Naphthalen-1-ylmethylsulfanyl)-7H-purine;5-HT Receptor,cyclin B1,cyclinD1,Inhibitor,Apoptosis,Serotonin Receptor,PU02,PU 02,HepG2,CDK4,5-hydroxytryptamine Receptor,inhibit
- CBNumber
- CB82686026
- Molecular Formula
- C16H12N4S
- Formula Weight
- 292.36
- MOL File
- 313984-77-9.mol
6-[(1-NaphthalenylMethyl)thio]-9H-purine Property
- storage temp.
- 2-8°C
- solubility
- Soluble to 100 mM in DMSO
- form
- Powder
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 14312
- Product name
- PU 02
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 14312
- Product name
- PU 02
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $158
- Updated
- 2024/03/01
- Product number
- 14312
- Product name
- PU 02
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $374
- Updated
- 2024/03/01
- Product number
- 14312
- Product name
- PU 02
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $661
- Updated
- 2024/03/01
- Product number
- 4700
- Product name
- PU02
- Purity
- ≥97%(HPLC)
- Packaging
- 50
- Price
- $397
- Updated
- 2021/12/16
6-[(1-NaphthalenylMethyl)thio]-9H-purine Chemical Properties,Usage,Production
Description
PU 02 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT3 with IC50 values ranging from 0.36 to 1.3 μM for human 5-HT3A, 5-HT3AB, 5-HT3AC, and 5-HT3AE in a FLIPR membrane potential assay using HEK293 cells expressing human recombinant receptors. It is selective for 5-HT3 over other Cys-loop containing receptors with IC50 values >100 μM for mouse, rat, and human nicotinic (nACh), human GABAA, and human glycine (Gly) receptors. PU 02 inhibits currents induced by 5-HT in COS-7 cells expressing human 5-HT3A (IC50 = 0.49 μM). PU 02 also reduces growth of HepG2 cells in a dose-dependent manner via induction of cell cycle arrest at the G2/M phase and apoptosis.
6-[(1-NaphthalenylMethyl)thio]-9H-purine Preparation Products And Raw materials
Raw materials
Preparation Products
6-[(1-NaphthalenylMethyl)thio]-9H-purine Suppliers
- Tel
- --
- Fax
- --
- customerservice@tocris.co.uk
- Country
- United Kingdom
- ProdList
- 5726
- Advantage
- 77