ChemicalBook > CAS DataBase List > (3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid

(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid

Product Name
(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
CAS No.
117620-84-5
Chemical Name
(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
Synonyms
Levofloxacin-10;Levofloacin Impurity 8;Levofloacin Impurity J;Levofloxacin Impurity 2;Levofloxacin Impurity J;Levofloxacin Impurity 43;(S)-10-fluoro-3-methyl-7-oxo;(S)-10-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid;7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-
CBNumber
CB82694489
Molecular Formula
C13H10FNO4
Formula Weight
263.22
MOL File
117620-84-5.mol
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(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Property

solubility 
Methanol
form 
Solid
color 
White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
F591110
Product name
(3S)-10-Fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid
Packaging
100mg
Price
$1320
Updated
2021/12/16
Matrix Scientific
Product number
183532
Product name
10-Fluoro-2,3-dihydro-3-(S)-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid
Purity
95%
Packaging
1g
Price
$2146
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
64990
Product name
(3S)-10-Fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylicAcid
Packaging
10mg
Price
$650
Updated
2021/12/16
A1 Biochem Labs
Product number
6572551
Product name
10-Fluoro-2,3-dihydro-3-(S)-methyl-7-oxo-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylicacid
Purity
95%
Packaging
1g
Price
$1300
Updated
2021/12/16
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(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Chemical Properties,Usage,Production

Uses

(3S)-10-Fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid is an intermediate in the synthesis of Levofloxacin, an antibiotic used against gram-negative organisms.

Synthesis

(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid is synthesized by reacting ethyl (S)-10-fluoro-3-methyl-7-oxo- 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate with Potassium hydroxide in Tetrahydrofuran by reflux.1

References

[1] JEFFREY L. GRAY. Synthesis and Biological Testing of Non-Fluorinated Analogues of Levofloxacin.[J]. ChemInform, 2003, 34 42. DOI:10.1002/chin.200342162.

(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid Suppliers

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117620-84-5, (3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic AcidRelated Search:

Ofloxacin Levofloxacin hydrochloride Levofloxacin Levofloxacin Impurity 4 Levofloxacin N-oxide Levofloxacin Tetrafluoro Impurity 1 (3S)-10-(4-Ethyl-1-piperazinyl)-9-fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid (Levofloxacin IMpurity) (R)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid ethyl (S)-10-fluoro-3-methyl-7-oxo- 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate Levofloxacin Tetrafluoro Impurity 2 (3S)-9,10-difluoro-3-methyl-7-oxo-2,3,6,7-tetrahydro-5H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid Levofloxacin Related Compound C (25 mg) ((S)-ethyl 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate) N,N'-Desethylene Levofloxacin Hydrochloride Ethyl (S)-9,10-difluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylate Levofloxacin Impurity 7 Descarboxyl Levofloxacin Desmethyl Levofloxacin Levofloxacin Related CoMpound E

  • (3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
  • Levofloxacin Impurity 2
  • Levofloxacin (3S)-10-Fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
  • (S)-10-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
  • Levofloacin Impurity J
  • Levofloxacin Impurity J
  • Levofloxacin impurity 12/(3S)-10-Fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
  • (S)-10-fluoro-3-methyl-7-oxo
  • Levofloxacin-10
  • Levofloacin Impurity 8
  • 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-
  • Levofloxacin Impurity 43
  • 117620-84-5
  • Chiral Reagents, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
  • GYL