2-VALERYLOXYBENZOIC ACID
- Product Name
- 2-VALERYLOXYBENZOIC ACID
- CAS No.
- 64206-54-8
- Chemical Name
- 2-VALERYLOXYBENZOIC ACID
- Synonyms
- VSA;VALERYL SALICYLATE;VALEROYL SALICYLATE;VALERYLSALICYLIC ACID;salicylicacid,valerate;2-VALERYLOXYBENZOIC ACID;WJHZBTMHUNVIKC-UHFFFAOYSA-N;2-[(1-OXOPENTYL)OXY]-BENZOIC ACID;Benzoic acid, 2-[(1-oxopentyl)oxy]-;2-Valeryloxybenzoic acid, Valerylsalicylic acid, vsa
- CBNumber
- CB8270272
- Molecular Formula
- C12H14O4
- Formula Weight
- 222.24
- MOL File
- 64206-54-8.mol
2-VALERYLOXYBENZOIC ACID Property
- Melting point:
- 86-87 °C(lit.)
- Boiling point:
- 357.6±25.0 °C(Predicted)
- Density
- 1.175±0.06 g/cm3(Predicted)
- storage temp.
- Room temperature
- solubility
- DMSO: 24 mL/mL
- pka
- 3.01±0.36(Predicted)
- form
- A crystalline solid
- color
- white
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- V2889
- Product name
- Valeryl Salicylate
- Purity
- ≥98% (HPLC)
- Packaging
- 100mg
- Price
- $134
- Updated
- 2024/03/01
- Product number
- 70670
- Product name
- Valeroyl Salicylate
- Purity
- ≥99%
- Packaging
- 50mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 70670
- Product name
- Valeroyl Salicylate
- Purity
- ≥99%
- Packaging
- 100mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 70670
- Product name
- Valeroyl Salicylate
- Purity
- ≥99%
- Packaging
- 500mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 70670
- Product name
- Valeroyl Salicylate
- Packaging
- 1000mg
- Price
- $426
- Updated
- 2024/03/01
2-VALERYLOXYBENZOIC ACID Chemical Properties,Usage,Production
Uses
Valeryl salicylate is a selective inhibitor of Cox-1.
Definition
ChEBI: A valerate ester that is salicylic acid in which the phenolic hydrogen is replaced by a valeryl (pentanoyl) group.
Biological Activity
valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively [1].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively. in cos-1 cells expressing either cox-1 or -2, 500 μm of valeroyl salicylate inhibited human cox-1 and -2 by 85% and 15%, respectively. the half-lives for inactivation of human recombinant cox-1 in the presence of 500 μm valeroyl salicylate was 12 minutes [2].
References
[1]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.
[2]. bhattacharyya dk, lecomte m, dunn j, et al. selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. arch biochem biophys. 1995 feb 20;317(1):19-24.
2-VALERYLOXYBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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