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2-VALERYLOXYBENZOIC ACID

Product Name
2-VALERYLOXYBENZOIC ACID
CAS No.
64206-54-8
Chemical Name
2-VALERYLOXYBENZOIC ACID
Synonyms
VSA;VALERYL SALICYLATE;VALEROYL SALICYLATE;VALERYLSALICYLIC ACID;salicylicacid,valerate;2-VALERYLOXYBENZOIC ACID;WJHZBTMHUNVIKC-UHFFFAOYSA-N;2-[(1-OXOPENTYL)OXY]-BENZOIC ACID;Benzoic acid, 2-[(1-oxopentyl)oxy]-;2-Valeryloxybenzoic acid, Valerylsalicylic acid, vsa
CBNumber
CB8270272
Molecular Formula
C12H14O4
Formula Weight
222.24
MOL File
64206-54-8.mol
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2-VALERYLOXYBENZOIC ACID Property

Melting point:
86-87 °C(lit.)
Boiling point:
357.6±25.0 °C(Predicted)
Density 
1.175±0.06 g/cm3(Predicted)
storage temp. 
Room temperature
solubility 
DMSO: 24 mL/mL
pka
3.01±0.36(Predicted)
form 
A crystalline solid
color 
white
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V2889
Product name
Valeryl Salicylate
Purity
≥98% (HPLC)
Packaging
100mg
Price
$134
Updated
2024/03/01
Cayman Chemical
Product number
70670
Product name
Valeroyl Salicylate
Purity
≥99%
Packaging
50mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
70670
Product name
Valeroyl Salicylate
Purity
≥99%
Packaging
100mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
70670
Product name
Valeroyl Salicylate
Purity
≥99%
Packaging
500mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
70670
Product name
Valeroyl Salicylate
Packaging
1000mg
Price
$426
Updated
2024/03/01
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2-VALERYLOXYBENZOIC ACID Chemical Properties,Usage,Production

Uses

Valeryl salicylate is a selective inhibitor of Cox-1.

Definition

ChEBI: A valerate ester that is salicylic acid in which the phenolic hydrogen is replaced by a valeryl (pentanoyl) group.

Biological Activity

valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively [1].cyclooxygenase (cox), also known as prostaglandin-endoperoxide synthase (ptgs, pghs), is an enzyme responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin. cox-1 is the constitutive isoform and is mainly responsible for the synthesis of cytoprotective prostaglandins in the gastrointestinal tract (gi) and of the proaggregatory thromboxane in blood platelets. cox-2 is inducible and short-lived that is stimulated by endotoxin, cytokines, and mitogens. cox-2 plays important roles in prostaglandin biosynthesis in inflammatory cells the central nervous system [1][2].valeroyl salicylate is an irreversible and selective inhibitor of cyclooxygenase-1 (cox-1) with ic50 values of 0.8 and 15 mm for ovine cox-1 and -2, respectively. in cos-1 cells expressing either cox-1 or -2, 500 μm of valeroyl salicylate inhibited human cox-1 and -2 by 85% and 15%, respectively. the half-lives for inactivation of human recombinant cox-1 in the presence of 500 μm valeroyl salicylate was 12 minutes [2].

References

[1]. johnson jl, wimsatt j, buckel sd, et al. purification and characterization of prostaglandin h synthase-2 from sheep placental cotyledons. arch biochem biophys. 1995 dec 1;324(1):26-34.
[2]. bhattacharyya dk, lecomte m, dunn j, et al. selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. arch biochem biophys. 1995 feb 20;317(1):19-24.

2-VALERYLOXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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64206-54-8, 2-VALERYLOXYBENZOIC ACIDRelated Search:


  • VSA
  • VALERYL SALICYLATE
  • VALERYLSALICYLIC ACID
  • VALEROYL SALICYLATE
  • salicylicacid,valerate
  • 2-[(1-OXOPENTYL)OXY]-BENZOIC ACID
  • 2-VALERYLOXYBENZOIC ACID
  • WJHZBTMHUNVIKC-UHFFFAOYSA-N
  • 2-Valeryloxybenzoic acid, Valerylsalicylic acid, vsa
  • Benzoic acid, 2-[(1-oxopentyl)oxy]-
  • 64206-54-8
  • Biochemicals and Reagents
  • BioChemical
  • A to C
  • Cyclooxygenase
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme