Erlotinib iMpurity

Product Name: Erlotinib iMpurity
CAS No.: 183321-82-6
Chemical Name: Erlotinib iMpurity
Synonyms: Erlotinib EP Impurity L;Erlotinib impurity, 6,7-bis;Erlotinib iMpurity, 6,7-bis(2-chloroethoxy);6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine;6,7-Bis(2-chloroethoxy)-N-(3-ethynylphenyl)-4-quinazolinamine;4-Quinazolinamine, 6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)-;6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine? (Erlotinib Impurity）
CBNumber: CB82705064
Molecular Formula: C20H17Cl2N3O2
Formula Weight: 402.27
MOL File: 183321-82-6.mol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: B418975
Product name: 6,7-Bis(2-chloroethoxy)-N-(3-ethynylphenyl)-4-quinazolinamine
Packaging: 1mg
Price: $165
Updated: 2021/12/16

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Erlotinib iMpurity Chemical Properties,Usage,Production

Uses

6,7-Bis(2-chloroethoxy)-N-(3-ethynylphenyl)-4-quinazolinamine is an intermediate in the preparation of (bis(morpholinoalkoxy))(phenylamino)quinazolines derivatives as epidermal growth factor receptor (EGFR) inhibitors with anti proliferative activity against tumor cells.

Synthesis

Take N'-[2-cyano-4,5-bis(3-chloropropoxy)phenyl]-N,N-dimethylformamidine (1.00mmol), add 2.0mL glacial acetic acid and 4-(E)-aminobenzylpropene (1.10mmol), refluxed at 130 , TLC tracked [Expanding agent: ethyl acetate: petroleum ether (1:2, V/V)] to The reaction was completed, about reaction time 15 min. stop heating, evaporate glacial acetic acid under reduced pressure, add 10 mL of water, adjust the pH to 9-10 with ammonia, stirring for 30 min and then filtered, the filter cake was washed with water for 3 times, silica gel column chromatography separation [ethyl acetate: petroleum ether (1:4, V/V)] to obtain a white solid 4-[4-(E)-(propen-1-yl)phenylamino]-6,7-di( 3-chloropropoxy)quinazoline (91.9% yield).

Erlotinib iMpurity Preparation Products And Raw materials

Raw materials

Preparation Products

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Erlotinib iMpurity Suppliers

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6,7-Bis(2-chloroethoxy)-N-(3-ethynylphenyl)-4-quinazolinamine

6,7-bis(2-chloroethoxy)-N-(3-ethynylphenyl)quinazolin-4-amine? (Erlotinib Impurity）

Erlotinib EP Impurity L

183321-82-6