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ERLOTINIB MESYLATE

Product Name
ERLOTINIB MESYLATE
CAS No.
248594-19-6
Chemical Name
ERLOTINIB MESYLATE
Synonyms
CP-358;ERLOTINIB MESYLATE;Erlotinib (OSI-744) mesylate;Erlotinib mesylate (CP-358774;CP-358774;OSI-774;NSC 718781;R 1415;TARCEVA; CP-358774; OSI-774; NSC 718781; R 1415
CBNumber
CB7677124
Molecular Formula
C23H27N3O7S
Formula Weight
489.54
MOL File
248594-19-6.mol
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ERLOTINIB MESYLATE Property

storage temp. 
Store at -20°C
solubility 
25℃: DMSO
form 
Powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E625013
Product name
ErlotinibMesylate
Packaging
100mg
Price
$45
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611389
Product name
Erlotinib mesylate
Packaging
500mg
Price
$180.2
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611389
Product name
Erlotinib mesylate
Packaging
1g
Price
$265.2
Updated
2021/12/16
Biosynth Carbosynth
Product number
FE65018
Product name
Erlotinib mesylate
Packaging
250mg
Price
$275
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611389
Product name
Erlotinib mesylate
Packaging
5G
Price
$409.7
Updated
2021/12/16
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ERLOTINIB MESYLATE Chemical Properties,Usage,Production

Uses

Erlotinib mesylate (CP-358774 mesylate) inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vivo

There is a 1.49-fold statistically significant difference between AUC0-inf after p.o. administration of Erlotinib (5 mg/kg) comparing Bcrp1/Mdr1a/1b-/- and WT mice (7,419±1,720 versus 4,957±1,735 ng*h/mL respectively, P=0.01)[3]. The administration of Erlotinib (10 mg/kg/day, or 20 mg/kg/day) to Bleomycin (BLM)-treated rats shows no exacerbation of lung injuries in indices such as macroscopic findings, lung weights, histopathological scores (lung lesion density and lung fibrosis score), and pulmonary hydroxyproline (HyP) level. The result suggests that Erlotinib does not have any exacerbating effects on lung injuries induced by BLM in rats[4].

IC 50

EGFR: 2 nM (IC50)

References

[1] Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997 Nov 1;57(21):4838-48. PMID:9354447
[2] Ali S, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther, 2008, 7(6), 1708-1719. DOI:10.1158/1535-7163.MCT-08-0354
[3] Marchetti S, et al. Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice.Mol Cancer Ther. 2008 Aug;7(8):2280-7. DOI:10.1158/1535-7163.MCT-07-2250
[4] Adachi K, et al. Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats. J Toxicol Sci. 2010 Aug;35(4):503-14. DOI:10.2131/jts.35.503

ERLOTINIB MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ERLOTINIB MESYLATE Suppliers

China 28 Europe 2 United Kingdom 2 United States 6 Global 38
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
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Taizhou Tongxin Bio-Tech Co., Ltd
Tel
0523-86818997 18652728585
Email
sales@allyrise.com
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China
ProdList
2966
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60
Finetech Industry Limited
Tel
027-87465837 19945049750
Fax
027-8777-2287
Email
sales@finetechnology-ind.com
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China
ProdList
9637
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58
Suzhou yacoo science co.,Ltd
Tel
0512-87182056 18013166090
Fax
0512-87182056
Email
lingling.qi@yacoo.com.cn
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China
ProdList
6295
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60
Shenzhen Nexconn Pharmatechs Ltd.
Tel
0755-89396905
Email
admin@nexconn.com
Country
China
ProdList
299
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55
AdooQ Bioscience CHINA
Tel
025-58849295 18951903616;
Fax
025-68650336
Email
info@adooq.cn
Country
China
ProdList
2990
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60
Shanghai Synchem Pharma Co., ltd
Tel
21-619849051-1 18521059765
Email
synchempharma@aliyun.com
Country
China
ProdList
6468
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55
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
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58
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
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View Lastest Price from ERLOTINIB MESYLATE manufacturers

Career Henan Chemical Co
Product
Erlotinib mesylate 248594-19-6
Price
US $0.10/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1kg; 100kg; 1000kg
Release date
2019-12-24

248594-19-6, ERLOTINIB MESYLATERelated Search:

Erlotinib DesMethyl Erlotinib Carboxylate Acid 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Erlotinib D6 HCl Erlotinib iMpurity 2 Erlotinib Impurity Q Erlotinib 6-O-DesMethoxyethyl-6-O-chloroethyl Erlotinib Hydrochloride 4-CHLORO-6-(2-CHLORO-ETHOXY)-7-(2-METHOXY-ETHOXY)-QUINAZOLINE Erlotinib iMpurity Desmethyl Erlotinib Acetate 4-QuinazolinaMine, 7-(2-chloroethoxy)-N-(3-ethynylphenyl)-6-(2-Methoxyethoxy)- Erlotinib Impurity G Erlotinib CP 373413 4-Chloro-6,7-bis-(2-chloroethoxy)quinazoline Erlotinib Impurity 22 4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)-

  • ERLOTINIB MESYLATE
  • Erlotinib (OSI-744) mesylate
  • TARCEVA; CP-358774; OSI-774; NSC 718781; R 1415
  • Erlotinib mesylate (CP-358774
  • CP-358774;OSI-774;NSC 718781;R 1415
  • CP-358
  • 248594-19-6