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ERLOTINIB MESYLATE

Product Name
ERLOTINIB MESYLATE
CAS No.
248594-19-6
Chemical Name
ERLOTINIB MESYLATE
Synonyms
CP-358;ERLOTINIB MESYLATE;Erlotinib (OSI-744) mesylate;Erlotinib mesylate (CP-358774;CP-358774;OSI-774;NSC 718781;R 1415;TARCEVA; CP-358774; OSI-774; NSC 718781; R 1415
CBNumber
CB7677124
Molecular Formula
C23H27N3O7S
Formula Weight
489.54
MOL File
248594-19-6.mol
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ERLOTINIB MESYLATE Property

storage temp. 
Store at -20°C
solubility 
25℃: DMSO
form 
Powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
E625013
Product name
ErlotinibMesylate
Packaging
100mg
Price
$45
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611389
Product name
Erlotinib mesylate
Packaging
500mg
Price
$180.2
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611389
Product name
Erlotinib mesylate
Packaging
1g
Price
$265.2
Updated
2021/12/16
Biosynth Carbosynth
Product number
FE65018
Product name
Erlotinib mesylate
Packaging
250mg
Price
$275
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611389
Product name
Erlotinib mesylate
Packaging
5G
Price
$409.7
Updated
2021/12/16
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ERLOTINIB MESYLATE Chemical Properties,Usage,Production

Uses

Erlotinib mesylate (CP-358774 mesylate) inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib (mesylate) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

in vivo

There is a 1.49-fold statistically significant difference between AUC0-inf after p.o. administration of Erlotinib (5 mg/kg) comparing Bcrp1/Mdr1a/1b-/- and WT mice (7,419±1,720 versus 4,957±1,735 ng*h/mL respectively, P=0.01)[3]. The administration of Erlotinib (10 mg/kg/day, or 20 mg/kg/day) to Bleomycin (BLM)-treated rats shows no exacerbation of lung injuries in indices such as macroscopic findings, lung weights, histopathological scores (lung lesion density and lung fibrosis score), and pulmonary hydroxyproline (HyP) level. The result suggests that Erlotinib does not have any exacerbating effects on lung injuries induced by BLM in rats[4].

IC 50

EGFR: 2 nM (IC50)

References

[1] Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997 Nov 1;57(21):4838-48. PMID:9354447
[2] Ali S, et al. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer. Mol Cancer Ther, 2008, 7(6), 1708-1719. DOI:10.1158/1535-7163.MCT-08-0354
[3] Marchetti S, et al. Effect of the ATP-binding cassette drug transporters ABCB1, ABCG2, and ABCC2 on erlotinib hydrochloride (Tarceva) disposition in in vitro and in vivo pharmacokinetic studies employing Bcrp1-/-/Mdr1a/1b-/- (triple-knockout) and wild-type mice.Mol Cancer Ther. 2008 Aug;7(8):2280-7. DOI:10.1158/1535-7163.MCT-07-2250
[4] Adachi K, et al. Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in rats. J Toxicol Sci. 2010 Aug;35(4):503-14. DOI:10.2131/jts.35.503

ERLOTINIB MESYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ERLOTINIB MESYLATE Suppliers

China 28 Europe 2 United Kingdom 2 United States 6 Global 38
Taizhou Tongxin Bio-Tech Co., Ltd
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Finetech Industry Limited
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AdooQ Bioscience CHINA
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Amadis Chemical Company Limited
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Beijing Jin Ming Biotechnology Co., Ltd.
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career henan chemical co
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Absin Bioscience Inc.
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Foshan Treasure Biotechnology Co., Ltd
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Nanjing Shizhou Biology Technology Co.,Ltd
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TargetMol Chemicals Inc.
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Biosynth Biological Technology (Suzhou) Co Ltd
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Adooq Bioscience LLC
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Biorbyt Ltd.
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View Lastest Price from ERLOTINIB MESYLATE manufacturers

Career Henan Chemical Co
Product
Erlotinib mesylate 248594-19-6
Price
US $0.10/KG
Min. Order
1KG
Purity
95%-99%
Supply Ability
1kg; 100kg; 1000kg
Release date
2019-12-24

248594-19-6, ERLOTINIB MESYLATERelated Search:

Erlotinib DesMethyl Erlotinib Carboxylate Acid 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Erlotinib D6 HCl Erlotinib iMpurity 2 Erlotinib Impurity Q Erlotinib 6-O-DesMethoxyethyl-6-O-chloroethyl Erlotinib Hydrochloride 4-CHLORO-6-(2-CHLORO-ETHOXY)-7-(2-METHOXY-ETHOXY)-QUINAZOLINE Erlotinib iMpurity Desmethyl Erlotinib Acetate 4-QuinazolinaMine, 7-(2-chloroethoxy)-N-(3-ethynylphenyl)-6-(2-Methoxyethoxy)- Erlotinib Impurity G Erlotinib CP 373413 4-Chloro-6,7-bis-(2-chloroethoxy)quinazoline Erlotinib Impurity 22 4-Quinazolinamine,N-(3-ethylphenyl)-6,7-bis(2-methoxyethoxy)-

  • ERLOTINIB MESYLATE
  • Erlotinib (OSI-744) mesylate
  • TARCEVA; CP-358774; OSI-774; NSC 718781; R 1415
  • Erlotinib mesylate (CP-358774
  • CP-358774;OSI-774;NSC 718781;R 1415
  • CP-358
  • 248594-19-6