YH239-EE

ChemicalBook > CAS DataBase List > YH239-EE

Product Name: YH239-EE
CAS No.: 1364488-67-4
Chemical Name: YH239-EE
Synonyms: CS-1286;YH239-EE;YH239-EE USP/EP/BP;YH 239-EE;YH 239 EE;Ethyl 3-[2-(tert-Butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoet;Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-;Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate;ethyl 3-[2-(tert-butylamino)-1-[(4-chlorophenyl)methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate;1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester;YH239-EE ethyl 3-[2-(tert-butylamino)-1-[(4-chlorophenyl)methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate
CBNumber: CB82710411
Molecular Formula: C25H27Cl2N3O4
Formula Weight: 504.41
MOL File: 1364488-67-4.mol

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YH239-EE Property

Boiling point:: 763.3±60.0 °C(Predicted)
Density: 1.313±0.06 g/cm3(Predicted)
storage temp.: Desiccate at -20°C
solubility: ≥50.4 mg/mL in DMSO; insoluble in H2O; ≥4.26 mg/mL in EtOH with ultrasonic
form: solid
pka: 13.20±0.30(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27678
Product name: YH 239-EE
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 27678
Product name: YH 239-EE
Packaging: 50mg
Price: $553
Updated: 2024/03/01

Cayman Chemical

Product number: 27678
Product name: YH 239-EE
Packaging: 10mg
Price: $152
Updated: 2024/03/01

Cayman Chemical

Product number: 27678
Product name: YH 239-EE
Packaging: 25mg
Price: $298
Updated: 2024/03/01

Tocris

Product number: 6719
Product name: YH239-EE
Purity: ≥98%(HPLC)
Packaging: 50
Price: $513
Updated: 2021/12/16

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YH239-EE Chemical Properties,Usage,Production

Uses

YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

Biological Activity

yh239-ee is a potent antagonist of p53-mdm2 [1].p53 is a transcription factor and functions as a tumor suppressor. mdm2 is a negative regulator of p53. the interaction of p53 and mdm2 has emerged as a novel target for anticancer drugs [1].yh239-ee is a potent p53-mdm2 antagonist. in oci-aml-3 cells, yh239-ee potently inhibited cell proliferation. in aml cell lines, yh239-ee induced a cell cycle arrest and cell accumulation in the sub-g1 phase. yh239-ee induced apoptosis by 11.8-fold, 5.6-fold and 13.1-fold in oci-aml-3, molm-13 and nb4 aml cell lines, respectively. in molm-13 cells, yh239 exhibited almost no apoptotic effect. however, yh239-ee significantly induced apoptosis. in molm-13 cells, (+)-yh239-ee and (−)-yh239-ee inhibited metabolic activity with ec50 values of 7.5 μm and 25.2 μm and induced apoptosis with 13.7% and 51.5% viable cells, respectively. (+)-yh239-ee (20 μm) induced p53 and significantly activated caspase 3 and 7 [1].

target

p53-MDM2

storage

Store at -20°C

References

[1]. huang y, wolf s, beck b, et al. discovery of highly potent p53-mdm2 antagonists and structural basis for anti-acute myeloid leukemia activities. acs chem biol, 2014, 9(3): 802-811.

YH239-EE Preparation Products And Raw materials

Raw materials

Preparation Products

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1364488-67-4, YH239-EERelated Search:

Y27632 (hydrochloride) Y320 YKL 06-061 YS 49 Yhhu-3792 YC-1 YKP-3089 BenzaMide, N-[4-chloro-3-(trifluoroMethyl)phenyl]-2-[2-(diMethylaMino)ethoxy]-6-ethoxy- AZD 1480 42-(Dimethylphosphinate)rapamycin PD 0325901 CAL-101 Nutlin 3a Erlotinib hydrochloride

Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate

YH239-EE ethyl 3-[2-(tert-butylamino)-1-[(4-chlorophenyl)methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate

Ethyl 3-[2-(tert-Butylamino)-1-[N-(4-chlorobenzyl)formamido]-2-oxoet

YH239-EE 6-Chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-1H-indole-2-carboxylic acid Ethyl Ester

ethyl 3-[2-(tert-butylamino)-1-[(4-chlorophenyl)methyl-formylamino]-2-oxoethyl]-6-chloro-1H-indole-2-carboxylate

Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-

YH239-EE

YH 239-EE;YH 239 EE

CS-1286

1H-Indole-2-carboxylic acid, 6-chloro-3-[1-[[(4-chlorophenyl)methyl]formylamino]-2-[(1,1-dimethylethyl)amino]-2-oxoethyl]-, ethyl ester

YH239-EE USP/EP/BP

1364488-67-4

C25H27Cl2N3O4

Inhibitors