Cerdulatinib
- Product Name
- Cerdulatinib
- CAS No.
- 1198300-79-6
- Chemical Name
- Cerdulatinib
- Synonyms
- PRT-062070;CS-1823;PRT2070);Cerdulatinib;Cerdulatinib D5;Cerdulatinib (PRT2070);PRT062070(Cerdulatnib);Cerdulatinib(PRT-062070;PRT 062070 (Cerdulatinib);Cerdulatinib trifluoroacetate salt
- CBNumber
- CB82715618
- Molecular Formula
- C20H27N7O3S
- Formula Weight
- 445.54
- MOL File
- 1198300-79-6.mol
Cerdulatinib Property
- Melting point:
- >211°C (dec.)
- Boiling point:
- 741.9±70.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 14.17±0.50(Predicted)
- color
- Light Yellow Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 20076
- Product name
- Cerdulatinib
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 20076
- Product name
- Cerdulatinib
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $115
- Updated
- 2024/03/01
- Product number
- 20076
- Product name
- Cerdulatinib
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $225
- Updated
- 2024/03/01
- Product number
- 20076
- Product name
- Cerdulatinib
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $419
- Updated
- 2024/03/01
- Product number
- C273000
- Product name
- Cerdulatinib(PRT2070)
- Packaging
- 100mg
- Price
- $590
- Updated
- 2021/12/16
Cerdulatinib Chemical Properties,Usage,Production
Uses
Cerdulatinib (PRT2070), acts as a novel oral and dual spleen tyrosine kinase (Syk) and janus kinase (JAK) inhibitor. Preferentially selects for JAK inhibitors (JAK1 and JAK3 primarily), preventing cytokine mediated signaling and functional responses varying cell types. Potential anti-cancer agent.
Biological Activity
cerdulatinib (prt062070) is a potent and selective inhibitor of syk and jak.[1]the jak/stat cascade, which has been implicated in hematopoiesis and cytokine signaling, is present in humans and flies. worms. the syk/zap70 kinases play an important role in human t and b cell signaling.[3]cerdulatinib can induce apoptosis via down-regulation of mcl1 protein and parp cleavage. through the inhibition of rb phosphorylation and down-regulation of cyclin e,the cerdulatinib can also block g1/s transition and cause cell cycle arrest. further analyses of the cell signaling activities showed that stat3 phosphorylation was sensitive to inhibition by cerdulatinib in abc cell lines while phosphorylation of syk, plcg2, akt and erk is reported to be sensitive to inhibition by cerdulatinib in gcb cell lines.[2]cerdulatinib is effective in rodent models of b-cell lymphoma and autoimmune disease and has exhibited anti-tumor activity in genetically diverse b-cell lymphoma cell lines and is more effective than syk- or jak- selective inhibitors alone.[1]
References
[1] manish patel , pau hamlin, md, etal. , a phase i open-label, multi-dose escalation study of the dual syk/jak inhibitor prt062070 (cerdulatinib) in patients with relapsed/refractory b cell malignancies. blood: 124 (21) ; december 6, 2014.
[2] y. lynn wang, md phd, jiao ma, phd, etal., syk and stat3 are active in diffuse large b-cell lymphoma: activity of cerdulatinib, a dual syk/jak inhibitor. blood: 124 (21) ; december 6, 2014.
[3]morrison dk, murakami ms, cleghon v. protein kinases and phosphatases in the drosophila genome. j cell biol. 2000 jul 24;150(2):f57-62.
Cerdulatinib Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Cerdulatinib manufacturers
- Product
- Cerdulatinib 1198300-79-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Cerdulatinib 1198300-79-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
- Product
- Cerdulatinib 1198300-79-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%-99.9%
- Supply Ability
- 100kg
- Release date
- 2020-03-05