ChemicalBook > CAS DataBase List > 2-((2,4-DiMethylphenyl)thio)phenylaMine

2-((2,4-DiMethylphenyl)thio)phenylaMine

Product Name
2-((2,4-DiMethylphenyl)thio)phenylaMine
CAS No.
1019453-85-0
Chemical Name
2-((2,4-DiMethylphenyl)thio)phenylaMine
Synonyms
VOR-IM D;VOR-IM B;Vortioxetine Impurity 89;Vortioxetine Impurity 60;2-((2,4-dimethylphenyl)thio)aniline;2-((2,4-DiMethylphenyl)thio)phenylaMine;2-[(2,4-diMethylphenyl)thio]-BenzenaMine;Benzenamine, 2-[(2,4-dimethylphenyl)thio]-;(2,4-Dimethylphenyl) (2-aminophenyl)sulfide;Wortioxetine intermediate: 2-((2,4-dimethylphenyl) thio) aniline
CBNumber
CB82716983
Molecular Formula
C14H15NS
Formula Weight
229.34
MOL File
1019453-85-0.mol
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2-((2,4-DiMethylphenyl)thio)phenylaMine Property

Boiling point:
341.3±30.0 °C(Predicted)
Density 
1.14±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Sparingly), Methanol (Sparingly)
pka
3.12±0.10(Predicted)
form 
Oil to Semi-Solid
color 
Dark Brown to Very Dark Red
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D447335
Product name
2-[(2,4-Dimethylphenyl)sulfanyl]aniline
Packaging
50mg
Price
$45
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
93282
Product name
2-[(2,4-Dimethylphenyl)sulfanyl]aniline
Packaging
50mg
Price
$345
Updated
2021/12/16
AK Scientific
Product number
0526DD
Product name
2-((2,4-Dimethylphenyl)thio)aniline
Packaging
25g
Price
$508
Updated
2021/12/16
Ambeed
Product number
A400978
Product name
2-((2,4-Dimethylphenyl)thio)aniline
Purity
97%
Packaging
1g
Price
$29
Updated
2021/12/16
Ambeed
Product number
A400978
Product name
2-((2,4-Dimethylphenyl)thio)aniline
Purity
97%
Packaging
5g
Price
$100
Updated
2021/12/16
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2-((2,4-DiMethylphenyl)thio)phenylaMine Chemical Properties,Usage,Production

Uses

2-[(2,4-Dimethylphenyl)sulfanyl]aniline is used in the study of N-O-glucuronide metabolites of Lu AA21004 (Vortioxetine [V766000]), an antidepressant.

Synthesis

4214-28-2

137-07-5

1019453-85-0

Using 4-iodo-m- dimethylbenzene (1.43 mL, 10.0 mmol) and 2-aminothiophenol (1.07 mL, 10.0 mmol) as raw materials, the above raw materials were mixed with cuprous iodide (0.19 g, 1.0 mmol), potassium carbonate (6.90 g, 50.0 mmol) and dried and degassed dimethylsulfoxide (50 mL) under nitrogen protection at 120 °C for 16 h with stirring. After completion of the reaction, the mixture was cooled to room temperature, diluted with water (50 mL) and the product was extracted with ethyl acetate (2 x 150 mL). The organic layers were combined and washed sequentially with water (3 x 150 mL) and brine (3 x 150 mL). The organic phase was dried over anhydrous magnesium sulfate and the solvent was concentrated under reduced pressure to afford 2-((2,4-dimethylphenyl)thio)aniline as a dark colored oil (2.15 g, 94% yield). The structure of the product was confirmed by nuclear magnetic resonance hydrogen spectroscopy (1H NMR, CDCl3, 500 MHz) and mass spectrometry (ESI): 1H NMR δ 2.28 (s, 3H), 2.40 (s, 3H), 4.24 (br s, 2H), 6.71 (d, J = 8.1 Hz, 1H), 6.75-6.81 (m, 2H), 6.87 (m, 1H) 7.02 (m, 1H), 7.23 (m, 1H), 7.38 (dd, J = 1.5, 7.7 Hz, 1H); MS (ESI) m/z: 230 [MH]+.

References

[1] Patent: WO2015/155153, 2015, A1. Location in patent: Page/Page column 15

2-((2,4-DiMethylphenyl)thio)phenylaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-((2,4-DiMethylphenyl)thio)phenylaMine manufacturers

Jinan Ruitong Biotech Co., Ltd.
Product
2-((2,4-Dimethylphenyl)thio)aniline 1019453-85-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1
Release date
2025-08-26
Career Henan Chemical Co
Product
2-((2,4-DiMethylphenyl)thio)phenylaMine 1019453-85-0
Price
US $6.60/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2019-12-30

1019453-85-0, 2-((2,4-DiMethylphenyl)thio)phenylaMineRelated Search:

Vortioxetine Impurity 4 3,5-DIMETHYLTHIOPHENOL 1-[(2-Bromophenyl)thio]-2,4-dimethylbenzene Vortioxetine impurity S BIS(2-BROMOETHYL)AMINE HYDROBROMIDE Vortioxetine Impurity 37 HCl 1,2-Bis(piperazin-1-yl)benzene Vortioxetine Impurity 2 1-[2-[(5-chloro-2,4-diMethylphenyl)thio]phenyl]- Piperazine 1-(2-BROMOPHENYL)PIPERAZINE 2,4-Dimethylbenzenethiol 3,4-DIMETHYLTHIOPHENOL 1-[2-[(2,4-diMethylphenyl)sulfinyl]phenyl]- Piperazine di(2,4-xylyl) disulphide 1-[2-[(2,4-diMethylphenyl)thio]phenyl]-4-[2-(1-piperazinyl)phenyl]- Piperazine Vortioxetine hydrobromide 2,4-DIMETHYLDIPHENYLSULFIDE Vortioxetine Impurity 1

  • Wortioxetine intermediate: 2-((2,4-dimethylphenyl) thio) aniline
  • 2-((2,4-DiMethylphenyl)thio)phenylaMine
  • 2-[(2,4-diMethylphenyl)thio]-BenzenaMine
  • VOR-IM B
  • VOR-IM D
  • 2-((2,4-dimethylphenyl)thio)aniline
  • Vortioxetine Impurity 60
  • Benzenamine, 2-[(2,4-dimethylphenyl)thio]-
  • Vortioxetine Impurity 89
  • (2,4-Dimethylphenyl) (2-aminophenyl)sulfide
  • 1019453-85-0