E-7449

Product Name: E-7449
CAS No.: 1140964-99-3
Chemical Name: E-7449
Synonyms: E7449;E-7449;2X-121);E7449;E 7449;UNII-9X5A2QIA7C;Stenoparib (E7449);E7449, 10 mM in DMSO;Stenoparib, E7449, 2X-121;Stenoparib（E7449，2X-121，MGI25036）;E7449,PARP,Inhibitor,inhibit,E 7449,E-7449,poly ADP ribose polymerase
CBNumber: CB82729361
Molecular Formula: C18H15N5O
Formula Weight: 317.34
MOL File: 1140964-99-3.mol

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E-7449 Property

Density: 1.53±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:0.2(Max Conc. mg/mL);0.63(Max Conc. mM)
form: A crystalline solid
pka: 9.51±0.20(Predicted)
color: Light yellow to yellow
InChI: InChI=1S/C18H15N5O/c24-18-13-6-3-7-14-16(13)17(21-22-18)20-15(19-14)10-23-8-11-4-1-2-5-12(11)9-23/h1-7H,8-10H2,(H,22,24)(H,19,20,21)
InChIKey: JLFSBHQQXIAQEC-UHFFFAOYSA-N
SMILES: N1=C2C3C(C(=O)NNC=3N=C1CN1CC3=C(C1)C=CC=C3)=CC=C2

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21658
Product name: E7449
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21658
Product name: E7449
Purity: ≥98%
Packaging: 5mg
Price: $145
Updated: 2024/03/01

Cayman Chemical

Product number: 21658
Product name: E7449
Purity: ≥98%
Packaging: 10mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 21658
Product name: E7449
Purity: ≥98%
Packaging: 25mg
Price: $571
Updated: 2024/03/01

Usbiological

Product number: 447764
Product name: E 7449
Packaging: 1mg
Price: $468
Updated: 2021/12/16

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E-7449 Chemical Properties,Usage,Production

Uses

E 7449 is a dual inhibitor of PARP1/2 and tankyrase1/2 exhibits anti-tumor activity in BRCA-deficient in vivo models. PARP1/2 and tankyrase1/2 are involved with DNA damage and canonical Wnt/β-catenin signaling, respectively.

in vivo

Stenoparib moderately inhibits the growth of tumors at 100 mg/kg, and significantly ehhances the inhibition via 10, 30 and 100 mg/kg oral dosing in combination with temozolomide (TMZ) in the mouse melanoma B16-F10 isograft model. Stenoparib (30 or 100 mg/kg, p.o.) inhibits PARP, shows anti-tumor activity, and is well-tolerated without any obvious body weight loss or deaths in a BRCA mutant xenograft model. Stenoparib (30, 100 or 300 mg/kg, p.o.) suppresses re-growth of hair in a dose dependent manner, and blocks Wnt signaling in C57BL/6 mice. Stenoparib (100 mg/kg, p.o.) combined with MEK inhibitor exhibits antitumor activity in a Wnt1 subcutaneous model (mammary tumors initially isolated from Wnt1 (int-1) transgenic mice)^[1].

IC 50

PARP2: 1 nM (IC₅₀); PARP1: 2 nM (IC₅₀); TNKS1: 50 nM (IC₅₀); TNKS2: 50 nM (IC₅₀)

E-7449 Preparation Products And Raw materials

Raw materials

Preparation Products

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E-7449 Suppliers

China 76 United States 8 Global 84

Deyang Sino Biotech. Co., LTD

Tel: +86-19182167371 +86-19182167371;
Email: service@synlord.com
Country: China
ProdList: 110
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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

LETOPHARM LIMITED

Tel: +86-21-5821 5861
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Email: sales@letopharm.com
Country: China
ProdList: 2384
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Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4768
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9923
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Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
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Country: China
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Shanghai YuanYe Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

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Shanghai SuperLan Chemcial Technique Centre

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Beijing Solarbio Science & Tecnology Co., Ltd.

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1140964-99-3, E-7449Related Search:

E7449

E-7449

8-(1,3-dihydro-isoindol-2-ylmethyl)-2,9-dihydro-1,2,7,9-tetraaza-phenalen-3-one

E7449;E 7449

3H-Pyridazino[3,4,5-de]quinazolin-3-one, 8-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-1,2-dihydro-

UNII-9X5A2QIA7C

Stenoparib (E7449)

E7449,PARP,Inhibitor,inhibit,E 7449,E-7449,poly ADP ribose polymerase

Stenoparib, E7449, 2X-121

Stenoparib（E7449，2X-121，MGI25036）

8-(Isoindolin-2-ylmethyl)-1,2-dihydro-3H-pyridazino[3,4,5-de]quinazolin-3-one

E7449, 10 mM in DMSO

2X-121)

1140964-99-3