ChemicalBook > CAS DataBase List > E-7449

E-7449

Product Name
E-7449
CAS No.
1140964-99-3
Chemical Name
E-7449
Synonyms
E7449;E-7449;E7449;E 7449;UNII-9X5A2QIA7C;Stenoparib (E7449);E7449, 10 mM in DMSO;Stenoparib, E7449, 2X-121;Stenoparib（E7449，2X-121，MGI25036）;E7449,PARP,Inhibitor,inhibit,E 7449,E-7449,poly ADP ribose polymerase;8-(Isoindolin-2-ylmethyl)-1,2-dihydro-3H-pyridazino[3,4,5-de]quinazolin-3-one
CBNumber
CB82729361
Molecular Formula
C18H15N5O
Formula Weight
317.34
MOL File
1140964-99-3.mol
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E-7449 Property

Density 
1.53±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:0.2(Max Conc. mg/mL);0.63(Max Conc. mM)
form 
A crystalline solid
pka
9.51±0.20(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H372Causes damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21658
Product name
E7449
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21658
Product name
E7449
Purity
≥98%
Packaging
5mg
Price
$145
Updated
2024/03/01
Cayman Chemical
Product number
21658
Product name
E7449
Purity
≥98%
Packaging
10mg
Price
$275
Updated
2024/03/01
Cayman Chemical
Product number
21658
Product name
E7449
Purity
≥98%
Packaging
25mg
Price
$571
Updated
2024/03/01
Usbiological
Product number
447764
Product name
E 7449
Packaging
1mg
Price
$468
Updated
2021/12/16
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E-7449 Chemical Properties,Usage,Production

Uses

E 7449 is a dual inhibitor of PARP1/2 and tankyrase1/2 exhibits anti-tumor activity in BRCA-deficient in vivo models. PARP1/2 and tankyrase1/2 are involved with DNA damage and canonical Wnt/β-catenin signaling, respectively.

E-7449 Preparation Products And Raw materials

Raw materials

Preparation Products

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E-7449 Suppliers

China 70 United States 8 Global 78
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1140964-99-3, E-7449Related Search:


  • E7449
  • E-7449
  • 8-(1,3-dihydro-isoindol-2-ylmethyl)-2,9-dihydro-1,2,7,9-tetraaza-phenalen-3-one
  • E7449;E 7449
  • 3H-Pyridazino[3,4,5-de]quinazolin-3-one, 8-[(1,3-dihydro-2H-isoindol-2-yl)methyl]-1,2-dihydro-
  • UNII-9X5A2QIA7C
  • Stenoparib (E7449)
  • E7449,PARP,Inhibitor,inhibit,E 7449,E-7449,poly ADP ribose polymerase
  • Stenoparib, E7449, 2X-121
  • Stenoparib（E7449，2X-121，MGI25036）
  • 8-(Isoindolin-2-ylmethyl)-1,2-dihydro-3H-pyridazino[3,4,5-de]quinazolin-3-one
  • E7449, 10 mM in DMSO
  • 1140964-99-3