BRD73954
- Product Name
- BRD73954
- CAS No.
- 1440209-96-0
- Chemical Name
- BRD73954
- Synonyms
- CS-1777;BRD73954;BRD-73954;BRD 73954;N1-hydroxy-N3-phenethylisophthalamide;N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide;1,3-Benzenedicarboxamide, N1-hydroxy-N3-(2-phenylethyl)-;BRD73954, 1-N-hydroxy-3-N-(2-phenylethyl)benzene-1,3-dicarboxamide;N1-hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide BRD73954
- CBNumber
- CB82730826
- Molecular Formula
- C16H16N2O3
- Formula Weight
- 284.31
- MOL File
- 1440209-96-0.mol
BRD73954 Property
- Melting point:
- 172-175oC
- Density
- 1.245±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 8.56±0.10(Predicted)
- color
- Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML1361
- Product name
- BRD73954
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $129
- Updated
- 2022/05/15
- Product number
- SML1361
- Product name
- BRD73954
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $513
- Updated
- 2022/05/15
- Product number
- 16919
- Product name
- BRD73954
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 16919
- Product name
- BRD73954
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- 16919
- Product name
- BRD73954
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $632
- Updated
- 2024/03/01
BRD73954 Chemical Properties,Usage,Production
Description
BRD73954 is a dual inhibitor of histone deacetylase 6 (HDAC6) and HDAC8 (IC50s = 36 and 120 nM, respectively). It is selective for HDAC6 and -8 over HDAC1-5, -7, and -9 (IC50s = 12, 9, 23, >33, >33, 13, and >33 μM, respectively). BRD73954 (10 μM) increases acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, -2, and -3, in HeLa cells.
Uses
BRD73954 is a small molecule inhibitor which has the ability to inhibit HDAC6 and HDAC8. Affects cell adhesion and mobility in cells.
storage
Store at +4°C
References
[1]. olson de, wagner ff, kaya t, et al. discovery of the first histone deacetylase 6/8 dual inhibitors. j med chem, 2013, 56(11): 4816-4820.
BRD73954 Preparation Products And Raw materials
Raw materials
Preparation Products
BRD73954 Suppliers
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View Lastest Price from BRD73954 manufacturers
- Product
- BRD73954 1440209-96-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98-100%
- Supply Ability
- 1000kg
- Release date
- 2018-08-20