6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
- Product Name
- 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
- CAS No.
- 83797-69-7
- Chemical Name
- 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
- Synonyms
- 6-OAU;CS-2658;GTPL5846;6-OAU, >98%;GTPL5846, >98%;6-OAU(GTPL5846);GTPL-5846 (6-OAU);GTPL 5846;GTPL5846;6-OAU;GTPL-5846;6-(Octylamino)-2,4(1H,3H)-pyrimidinedione;6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
- CBNumber
- CB82736888
- Molecular Formula
- C12H21N3O2
- Formula Weight
- 239.31
- MOL File
- 83797-69-7.mol
6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Property
- storage temp.
- Store at -20°C
- solubility
- ≤0.25mg/ml in DMSO;0.25mg/ml in dimethyl formamide
- form
- crystalline solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 17687
- Product name
- 6-OAU
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 17687
- Product name
- 6-OAU
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $388
- Updated
- 2024/03/01
- Product number
- 17687
- Product name
- 6-OAU
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $638
- Updated
- 2024/03/01
- Product number
- C5367
- Product name
- 6-OAU
- Packaging
- 10mg
- Price
- $677
- Updated
- 2021/12/16
- Product number
- C5367
- Product name
- 6-OAU
- Packaging
- 1mg
- Price
- $90
- Updated
- 2021/12/16
6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Chemical Properties,Usage,Production
Description
GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations. GPR84 is expressed in leukocytes and its expression is further induced by LPS. 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM). It has insignificant actions at a panel of 69 other receptors, channels, or transporters. 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages. In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.
in vitro
a previous study identified 6-oau as a surrogate agonist for gpr84. it was found that 6-oau and potential ligands were able to stimulate [(35)s]gtp binding and accumulate phosphoinositides in a gpr84-dependent manner. moreover, 6-oau could internalize gpr84-egfp from the cell surface. in addition, results showed that both 6-oau and the potential ligands could elicite chemotaxis of human polymorphonuclear leukocytes (pmns) and macrophages and amplify lps-stimulated production of the proinflammatory cytokine il-8 from pmns and tnfα from macrophages [1].
in vivo
animal study found that the iv injection of 6-oau was able to raise the blood cxcl1 level in rats. in addition, the inoculation of 6-oau into the rat air pouch could accumulate pmns and macrophages in the site [1].
References
[1] suzuki, m. ,takaishi, s.,nagasaki, m., et al. medium-chain fatty acid-sensing receptor, gpr84, is a proinflammatory receptor. the journal of biological chemisty 288(15), 10684-10691 (2013).
6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione manufacturers
- Product
- 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione 83797-69-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20kg
- Release date
- 2019-09-05