ChemicalBook > CAS DataBase List > 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione

6-(octylaMino)pyriMidine-2,4(1H,3H)-dione

Product Name
6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
CAS No.
83797-69-7
Chemical Name
6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
Synonyms
6-OAU;CS-2658;GTPL5846;6-OAU, >98%;GTPL5846, >98%;6-OAU(GTPL5846);GTPL-5846 (6-OAU);GTPL 5846;GTPL5846;6-OAU;GTPL-5846;6-(Octylamino)-2,4(1H,3H)-pyrimidinedione;6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
CBNumber
CB82736888
Molecular Formula
C12H21N3O2
Formula Weight
239.31
MOL File
83797-69-7.mol
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6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Property

storage temp. 
Store at -20°C
solubility 
≤0.25mg/ml in DMSO;0.25mg/ml in dimethyl formamide
form 
crystalline solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17687
Product name
6-OAU
Purity
≥98%
Packaging
1mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
17687
Product name
6-OAU
Purity
≥98%
Packaging
5mg
Price
$388
Updated
2024/03/01
Cayman Chemical
Product number
17687
Product name
6-OAU
Purity
≥98%
Packaging
10mg
Price
$638
Updated
2024/03/01
ApexBio Technology
Product number
C5367
Product name
6-OAU
Packaging
1mg
Price
$90
Updated
2021/12/16
ApexBio Technology
Product number
C5367
Product name
6-OAU
Packaging
5mg
Price
$406
Updated
2021/12/16
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6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Chemical Properties,Usage,Production

Description

GPR84 is a Gαi protein-coupled receptor that is activated by medium-chain free fatty acids, but only at micromolar concentrations. GPR84 is expressed in leukocytes and its expression is further induced by LPS. 6-OAU is a synthetic agonist for GPR84 (EC50 = 512 nM). It has insignificant actions at a panel of 69 other receptors, channels, or transporters. 6-OAU promotes chemotaxis in human neutrophils (EC50 = 318 nM) and amplifies TNF-α production by LPS-treated U937 macrophages. In rats, 6-OAU (1 mg/ml) drives the recruitment of neutrophils and macrophages when injected into a subcutaneous air pouch and raises serum levels of CXCL1 (growth-regulated α protein) when delivered intravenously.

in vitro

a previous study identified 6-oau as a surrogate agonist for gpr84. it was found that 6-oau and potential ligands were able to stimulate [(35)s]gtp binding and accumulate phosphoinositides in a gpr84-dependent manner. moreover, 6-oau could internalize gpr84-egfp from the cell surface. in addition, results showed that both 6-oau and the potential ligands could elicite chemotaxis of human polymorphonuclear leukocytes (pmns) and macrophages and amplify lps-stimulated production of the proinflammatory cytokine il-8 from pmns and tnfα from macrophages [1].

in vivo

animal study found that the iv injection of 6-oau was able to raise the blood cxcl1 level in rats. in addition, the inoculation of 6-oau into the rat air pouch could accumulate pmns and macrophages in the site [1].

References

[1] suzuki, m. ,takaishi, s.,nagasaki, m., et al. medium-chain fatty acid-sensing receptor, gpr84, is a proinflammatory receptor. the journal of biological chemisty 288(15), 10684-10691 (2013).

6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(octylaMino)pyriMidine-2,4(1H,3H)-dione Suppliers

China 47 India 1 United States 10 Global 58
Target molecule Corp.
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View Lastest Price from 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione manufacturers

Career Henan Chemical Co
Product
6-(octylaMino)pyriMidine-2,4(1H,3H)-dione 83797-69-7
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
20kg
Release date
2019-09-05

83797-69-7, 6-(octylaMino)pyriMidine-2,4(1H,3H)-dioneRelated Search:


  • 6-(octylaMino)pyriMidine-2,4(1H,3H)-dione
  • GTPL 5846;GTPL5846;6-OAU;GTPL-5846
  • CS-2658
  • 6-OAU, >98%
  • GTPL5846, >98%
  • GTPL5846
  • GTPL-5846 (6-OAU)
  • 6-OAU
  • 6-(Octylamino)-2,4(1H,3H)-pyrimidinedione
  • 6-OAU(GTPL5846)
  • 2,4(1H,3H)-Pyrimidinedione, 6-(octylamino)-
  • G protein coupled receptor 84,Inhibitor,IL-8,Sf9,ERK,HEK293,PMN,TNF-α,Lauric acid,MAPKs,U937,GPR84,inflammation,GTPL 5846,B. abortus,Extracellular signal regulated kinases,6 OAU,Cytokines,macrophage,GTPL-5846,6-OAU,6OAU,proinflammatory cytokine,G protein-coupled receptor,GTPγS,chemotaxis,rat air pouch model,inhibit
  • 83797-69-7
  • Inhibitors