ChemicalBook > CAS DataBase List > 2-bromo-4-chloronicotinaldehyde
2-bromo-4-chloronicotinaldehyde
- Product Name
- 2-bromo-4-chloronicotinaldehyde
- CAS No.
- 1289197-78-9
- Chemical Name
- 2-bromo-4-chloronicotinaldehyde
- Synonyms
- 2-bromo-4-chloronicotinaldehyde;2-bromo-4-chloropyridine-3-carbaldehyde;2-Bromo-4-chloropyridine-3-carboxaldehyde;2-Bromo-4-chloropyridine-4-carboxaldehyde;3-Pyridinecarboxaldehyde, 2-bromo-4-chloro-;2-Bromo-4-chloropyridine-3-carboxaldehyde 97%
- CBNumber
- CB82738246
- Molecular Formula
- C6H3BrClNO
- Formula Weight
- 220.45
- MOL File
- 1289197-78-9.mol
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2-bromo-4-chloronicotinaldehyde Property
- Melting point:
- 83-87°C
- Boiling point:
- 283.2±35.0 °C(Predicted)
- Density
- 1.800±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- -1.17±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C6H3BrClNO/c7-6-4(3-10)5(8)1-2-9-6/h1-3H
- InChIKey
- KCOAVFRTHTWKDO-UHFFFAOYSA-N
- SMILES
- C1(Br)=NC=CC(Cl)=C1C=O
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 762180
- Product name
- 2-Bromo-4-chloropyridine-3-carboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $184
- Updated
- 2023/06/20
AK Scientific
- Product number
- 0762AQ
- Product name
- 2-Bromo-4-chloropyridine-3-carboxaldehyde
- Packaging
- 1g
- Price
- $173
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0620827
- Product name
- 2-BROMO-4-CHLOROPYRIDINE-3-CARBALDEHYDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $454.04
- Updated
- 2021/12/16
Ambeed
- Product number
- A1467848
- Product name
- 2-Bromo-4-chloronicotinaldehyde
- Purity
- 97+%
- Packaging
- 100mg
- Price
- $26
- Updated
- 2021/12/16
Ambeed
- Product number
- A122314
- Product name
- 2-Bromo-4-chloronicotinaldehyde
- Purity
- 95%
- Packaging
- 100mg
- Price
- $26
- Updated
- 2021/12/16
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2-bromo-4-chloronicotinaldehyde Chemical Properties,Usage,Production
Synthesis
22918-01-0
68-12-2
1289197-78-9
GENERAL STEPS: To an anhydrous tetrahydrofuran (40 mL) solution of 2-bromo-4-chloropyridine (1.6 g, 8.0 mmol) was slowly added lithium diisopropylammonium solution (5.0 mL, 10.0 mmol, 2.0 M) over 5 minutes at -70 °C and stirring was continued for 1 hour at -70 °C. Subsequently, anhydrous N,N-dimethylformamide (1.3 g) was added dropwise over 3 minutes and the reaction mixture was stirred at the same temperature for another 30 minutes. After completion of the reaction, the reaction was quenched with saturated ammonium chloride solution (30 mL) and extracted with ethyl acetate (20 mL x 3). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using petroleum ether/ethyl acetate (20:1) as eluent to afford 2-bromo-4-chloropyridine-3-carboxaldehyde (114a) as a yellow solid (900 mg, 48% yield).1H NMR (500 MHz, DMSO) δ 10.21 (s, 1H), 8.52 (d, J = 5.5 Hz, 1H), 7.79 (d, J = 5.0 Hz, 1H).
References
[1] Patent: US2013/116262, 2013, A1. Location in patent: Paragraph 0307
[2] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0185
[3] Patent: US2013/116246, 2013, A1. Location in patent: Paragraph 0246
2-bromo-4-chloronicotinaldehyde Preparation Products And Raw materials
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Preparation Products
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View Lastest Price from 2-bromo-4-chloronicotinaldehyde manufacturers
Career Henan Chemical Co
- Product
- 2-bromo-4-chloronicotinaldehyde 1289197-78-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09