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2-bromo-4-chloronicotinaldehyde

Product Name
2-bromo-4-chloronicotinaldehyde
CAS No.
1289197-78-9
Chemical Name
2-bromo-4-chloronicotinaldehyde
Synonyms
2-bromo-4-chloronicotinaldehyde;2-bromo-4-chloropyridine-3-carbaldehyde;2-Bromo-4-chloropyridine-3-carboxaldehyde;2-Bromo-4-chloropyridine-4-carboxaldehyde;3-Pyridinecarboxaldehyde, 2-bromo-4-chloro-;2-Bromo-4-chloropyridine-3-carboxaldehyde 97%
CBNumber
CB82738246
Molecular Formula
C6H3BrClNO
Formula Weight
220.45
MOL File
1289197-78-9.mol
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2-bromo-4-chloronicotinaldehyde Property

Melting point:
83-87°C
Boiling point:
283.2±35.0 °C(Predicted)
Density 
1.800±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
form 
solid
pka
-1.17±0.10(Predicted)
Appearance
Off-white to yellow Solid
InChI
InChI=1S/C6H3BrClNO/c7-6-4(3-10)5(8)1-2-9-6/h1-3H
InChIKey
KCOAVFRTHTWKDO-UHFFFAOYSA-N
SMILES
C1(Br)=NC=CC(Cl)=C1C=O
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Safety

Hazard Codes 
T,Xi
Risk Statements 
25-36
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
762180
Product name
2-Bromo-4-chloropyridine-3-carboxaldehyde
Purity
97%
Packaging
1g
Price
$184
Updated
2023/06/20
American Custom Chemicals Corporation
Product number
HCH0620827
Product name
2-BROMO-4-CHLOROPYRIDINE-3-CARBALDEHYDE
Purity
95.00%
Packaging
5MG
Price
$454.04
Updated
2021/12/16
AK Scientific
Product number
0762AQ
Product name
2-Bromo-4-chloropyridine-3-carboxaldehyde
Packaging
1g
Price
$173
Updated
2021/12/16
Ambeed
Product number
A1467848
Product name
2-Bromo-4-chloronicotinaldehyde
Purity
97+%
Packaging
10g
Price
$480
Updated
2021/12/16
Ambeed
Product number
A122314
Product name
2-Bromo-4-chloronicotinaldehyde
Purity
95%
Packaging
10g
Price
$480
Updated
2021/12/16
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2-bromo-4-chloronicotinaldehyde Chemical Properties,Usage,Production

Synthesis

22918-01-0

68-12-2

1289197-78-9

GENERAL STEPS: To an anhydrous tetrahydrofuran (40 mL) solution of 2-bromo-4-chloropyridine (1.6 g, 8.0 mmol) was slowly added lithium diisopropylammonium solution (5.0 mL, 10.0 mmol, 2.0 M) over 5 minutes at -70 °C and stirring was continued for 1 hour at -70 °C. Subsequently, anhydrous N,N-dimethylformamide (1.3 g) was added dropwise over 3 minutes and the reaction mixture was stirred at the same temperature for another 30 minutes. After completion of the reaction, the reaction was quenched with saturated ammonium chloride solution (30 mL) and extracted with ethyl acetate (20 mL x 3). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using petroleum ether/ethyl acetate (20:1) as eluent to afford 2-bromo-4-chloropyridine-3-carboxaldehyde (114a) as a yellow solid (900 mg, 48% yield).1H NMR (500 MHz, DMSO) δ 10.21 (s, 1H), 8.52 (d, J = 5.5 Hz, 1H), 7.79 (d, J = 5.0 Hz, 1H).

References

[1] Patent: US2013/116262, 2013, A1. Location in patent: Paragraph 0307
[2] Patent: EP2773638, 2015, B1. Location in patent: Paragraph 0185
[3] Patent: US2013/116246, 2013, A1. Location in patent: Paragraph 0246

2-bromo-4-chloronicotinaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-bromo-4-chloronicotinaldehyde Suppliers

China 81 United States 3 Global 84
Weihai Huaixin Biotechnology Co., Ltd
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15662379806
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845423637@qq.com
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China
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Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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Shanghai Topbiochem Technology Co., Ltd
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021-58170097
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info@topbiochem.com
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China
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Shanghai T&W Pharmaceutical Co., Ltd.
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+86 21 61551611
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+86 21 50676805
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China
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Shanghai Jian Chao Chemical Technology Co., Ltd.
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150-2103-5486 18017383231
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Bide Pharmatech Ltd.
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400-164-7117 13681763483
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Chengdu Firster Pharmaceutical Co., Ltd.
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LABTER PHARMATECH(BEIJING) CO.,LTD
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010-56330744 18310155299
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sales@labter.com.cn
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China
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Sigma-Aldrich
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021-61415566 800-8193336
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orderCN@merckgroup.com
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China
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51395
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Xi'an NewProChem Co.,Ltd.
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15332490153
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QQ 2725398181
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newprochem@126.com
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China
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991
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View Lastest Price from 2-bromo-4-chloronicotinaldehyde manufacturers

Career Henan Chemical Co
Product
2-bromo-4-chloronicotinaldehyde 1289197-78-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

1289197-78-9, 2-bromo-4-chloronicotinaldehydeRelated Search:


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  • 1289197-78-9