ChemicalBook > CAS DataBase List > Diphenylphosphinic Chloride

Diphenylphosphinic Chloride

Product Name
Diphenylphosphinic Chloride
CAS No.
1499-21-4
Chemical Name
Diphenylphosphinic Chloride
Synonyms
DPPC;DIPHENYLPHOSPHINIC CHLORIDE;DPP-CL;Ph2POCl;phosphinic chL;Diphenylphoshinic;CHLORODIPHIOSPHINE OXIDE;DIPHENYLPHOSHINIC CHLORIDE;Diphenylphosphinic chlorid;DIPHENYLPHOSPHINYL CHLORIDE
CBNumber
CB8273899
Molecular Formula
C12H10ClOP
Formula Weight
236.63
MOL File
1499-21-4.mol
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Diphenylphosphinic Chloride Property

Melting point:
20°C
Boiling point:
222 °C/16 mmHg (lit.)
Density 
1.24 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.609(lit.)
Flash point:
79 °F
storage temp. 
2-8°C
solubility 
soluble in Chloroform, methanol
form 
Liquid
Specific Gravity
1.24
color 
Clear colorless to yellow
Water Solubility 
decomposes
Sensitive 
Moisture Sensitive
BRN 
975191
CAS DataBase Reference
1499-21-4(CAS DataBase Reference)
NIST Chemistry Reference
Diphenylphosphinic chloride(1499-21-4)
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Safety

Hazard Codes 
C,F
Risk Statements 
10-34
Safety Statements 
16-26-36/37/39-45
RIDADR 
UN 2920 8/PG 2
WGK Germany 
3
F 
10-21
Hazard Note 
Flammable/Corrosive
HazardClass 
8
PackingGroup 
II
HS Code 
29310095
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
230235
Product name
Diphenylphosphinic chloride
Purity
98%
Packaging
10g
Price
$75.4
Updated
2024/03/01
Sigma-Aldrich
Product number
230235
Product name
Diphenylphosphinic chloride
Purity
98%
Packaging
50g
Price
$296
Updated
2024/03/01
TCI Chemical
Product number
C1415
Product name
Diphenylphosphinic Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$121
Updated
2024/03/01
Alfa Aesar
Product number
A11721
Product name
Diphenylphosphinic chloride, 97+%
Packaging
5g
Price
$36.65
Updated
2024/03/01
Alfa Aesar
Product number
A11721
Product name
Diphenylphosphinic chloride, 97+%
Packaging
25g
Price
$118.65
Updated
2024/03/01
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Diphenylphosphinic Chloride Chemical Properties,Usage,Production

Chemical Properties

clear colorless to yellow liquid

Uses

Diphenylphosphinic chloride (Ph2POCl) is widely used as a precursor to synthesize various chiral phosphine bidentate ligands for asymmetric synthesis, in addition to several peptide coupling agents.

Application

Diphenylphosphinic chloride is a reagent that is used in the synthesis of bidentate ligands and peptide coupling agents. It is used as flame retardants. It also act as pharmaceutical adjuvant.

reaction suitability

reaction type: Buchwald-Hartwig Cross Coupling Reaction
reaction type: Heck Reaction
reaction type: Hiyama Coupling
reaction type: Negishi Coupling
reaction type: Sonogashira Coupling
reaction type: Stille Coupling
reaction type: Suzuki-Miyaura Coupling

Synthesis

To an oven-dried 100 mL, a two-necked flask fitted with a reflux condenser was added Et2O (depending on the Grignard reagent solution's concentration) and POCl3. The solution was cooled in an ice-salt mixture, and a Grignard reagent solution in Et2O was slowly added. After stirring with cooling for 30 min, the reaction mixture was brought to rt and stirred for the indicated time. The mixture was then cooled in an ice-salt mixture, and the alcohol and pyridine were slowly added. Stirring with cooling for 5 min was followed by reaction at rt. The reaction was quenched after the indicated time by cooling in an ice-salt mixture and adding sat aq NH4Cl. The crude mixture was then poured into CH2Cl2, washed three times with HCl, dried, filtered, and evaporated to dryness. The excess alcohol was removed using a short-path vacuum distillation apparatus, and the resulting crude product Diphenylphosphinic Chloride was purified by column chromatography.

Diphenylphosphinic Chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Diphenylphosphinic Chloride Suppliers

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View Lastest Price from Diphenylphosphinic Chloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Diphenylphosphinic Chloride 1499-21-4
Price
US $50.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-05-20
Speranza Chemical Co., Ltd.
Product
Diphenylphosphinic chloride, 98% 1499-21-4
Price
US $20.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200tons/ year
Release date
2020-03-11
XINXIANG RUNYU MATERIAL CO., LTD.
Product
Diphenylphosphinic Chloride 1499-21-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%+
Supply Ability
250KG
Release date
2025-01-10

1499-21-4, Diphenylphosphinic ChlorideRelated Search:

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