AF38469
- Product Name
- AF38469
- CAS No.
- 1531634-31-7
- Chemical Name
- AF38469
- Synonyms
- CS-2561;AF38469;AF38469 ，S7478;AF38469 (AF-38469);AF38469, 10 mM in DMSO;inhibit,AF 38469,Neurotensin Receptor,Inhibitor,AF38469;2-[(6-Methyl-2-pyridyl)carbamoyl]-5-(trifluoromethyl)benzoic Acid;2-((6-Methylpyridin-2-yl)carbamoyl)-5-(trifluoromethyl)benzoic acid;Benzoic acid, 2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-5-(trifluoromethyl)-
- CBNumber
- CB82744892
- Molecular Formula
- C15H11F3N2O3
- Formula Weight
- 324.25
- MOL File
- 1531634-31-7.mol
AF38469 Property
- Boiling point:
- 392.3±42.0 °C(Predicted)
- Density
- 1.448±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: Soluble; Ethanol: Soluble
- form
- A solid
- pka
- 2.83±0.36(Predicted)
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-4149
- Product name
- AF38469
- Purity
- 99.28%
- Packaging
- 5mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- CS-4149
- Product name
- AF38469
- Purity
- 99.28%
- Packaging
- 10mg
- Price
- $600
- Updated
- 2021/12/16
- Product number
- CS-4149
- Product name
- AF38469
- Purity
- 99.28%
- Packaging
- 50mg
- Price
- $1800
- Updated
- 2021/12/16
- Product number
- orb611584
- Product name
- AF38469
- Packaging
- 250mg
- Price
- $2395.3
- Updated
- 2021/12/16
- Product number
- CS-4149
- Product name
- AF38469
- Purity
- 99.28%
- Packaging
- 100mg
- Price
- $2520
- Updated
- 2021/12/16
AF38469 Chemical Properties,Usage,Production
Uses
AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.
in vivo
AF38469 (1 mg/kg; i.v.) has a low volume of distribution (blood volume of 0.7 L/kg) and low clearance (4.8 L/h/kg), and a half-life (t1/2) of 1.2 h in rat[1].
References
[1] Schroder TJ, et al. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80. DOI:10.1016/j.bmcl.2013.11.046
AF38469 Preparation Products And Raw materials
Raw materials
Preparation Products
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