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(R)-4-Propyldihydrofuran-2(3H)-one

Product Name
(R)-4-Propyldihydrofuran-2(3H)-one
CAS No.
63095-51-2
Chemical Name
(R)-4-Propyldihydrofuran-2(3H)-one
Synonyms
(R)-4-propyl-dihydro-furan-2-one;(4R)-4-Propyldihydrofuran-2(3H)-one;(4R)-4-propyloxolan-2-one;(4R)-4-propyltetrahydrofuran-2-one;(R)-Dihydro-4-propyl-2(3H)-furanone;(R)-Dihydro-4-propylfuran-2(3H)-one;BR150;Brisetan;Boisacetan;Buvacitan impurity 11
CBNumber
CB82747297
Molecular Formula
C7H12O2
Formula Weight
128.17
MOL File
63095-51-2.mol
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(R)-4-Propyldihydrofuran-2(3H)-one Property

Boiling point:
226.3±8.0 °C(Predicted)
Density 
0.983±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
form 
Oil
color 
Colourless
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC
Product number
D495305
Product name
(R)-Dihydro-4-propyl-2(3H)-furanone
Packaging
1g
Price
$315
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
APN0002377
Product name
(R)-4-PROPYLDIHYDROFURAN-2(3H)-ONE
Purity
95.00%
Packaging
5MG
Price
$504.94
Updated
2021/12/16
AK Scientific
Product number
2796CS
Product name
(R)-4-Propyldihydrofuran-2(3H)-one
Packaging
1g
Price
$223
Updated
2021/12/16
Ambeed
Product number
A230886
Product name
(R)-4-Propyldihydrofuran-2(3H)-one
Purity
97%
Packaging
25g
Price
$1105
Updated
2021/12/16
Chemenu
Product number
CM244546
Product name
(R)-4-Propyldihydrofuran-2(3H)-one
Purity
99%
Packaging
1000g
Price
$3128
Updated
2021/12/16
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(R)-4-Propyldihydrofuran-2(3H)-one Chemical Properties,Usage,Production

Description

(R)-4-Propyldihydrofuran-2(3H)-one is the key intermediate in the diastereoselective synthesis of Brivaracetam, an active ingredient with antiepileptic properties belonging to the racetam family.

Chemical Properties

(R)-4-Propyldihydrofuran-2(3H)-one is a yellow oily liquid, slightly soluble in chloroform, methanol and ethanol. It needs to be stored at 2-8°C.

Uses

(R)-Dihydro-4-propyl-2(3H)-furanone, is building block used in various chemical synthesis.

Synthesis

Add a solution of H5IO6 (24.429 g, 107.17 mmol) in water (43 mL) to a solution of (R)-2-benzylpentyl acetate (1.180 g) in CCl4 (27 mL) and CH3CN (27 mL) at 0 °C. Add RuCl3·nH2O (0.222 g, 1.07 mmol) slowly to the mixture at 0 °C. Stir the resultant mixture vigorously for 20 hours at room temperature. Quench the reaction with Et2O (50 mL) at 0 °C. Stir the mixture for 30 minutes. Extract the mixture with Et2O (3 × 50 mL).
Wash the combined organic layers with brine (30 mL). Dry the combined organic layers over anhydrous Na2SO4. Filter the combined organic layers. Remove the solvent. Dissolve the oil in aqueous NaOH (1 mol L-1, 40 mL). Stir the resulting solution overnight at room temperature. Wash the solution with Et2O (30 mL). Acidify the solution with aqueous HCl (6 mol L-1, 15 mL) at 0 °C. Stir the mixture overnight at room temperature. Saturate the aqueous layer with NaCl. Extract the mixture with Et2O (5 × 40 mL). Wash the combined organic layers with water, saturated aqueous Na2S2O3 (30 mL) and brine (30 mL).
Dry the combined organic layers over anhydrous Na2SO4. Filter the combined organic layers. Remove the solvent. Purify the residue by column chromatography on silica gel (hexane/acetone = 3/1) and distillation (162-209 °C/36 mmHg).

(R)-4-Propyldihydrofuran-2(3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-4-Propyldihydrofuran-2(3H)-one Suppliers

China 254 India 27 United States 7 Global 288
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
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United States
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Accela ChemBio Inc.
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+1-858-6993322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
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United States
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Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
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Aladdin Scientific
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+1-+1(833)-552-7181
Email
sales@aladdinsci.com
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United States
ProdList
52924
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Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
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Synthonix Inc
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United States
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Combi-Blocks Inc.
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sales@combi-blocks.com
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United States
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View Lastest Price from (R)-4-Propyldihydrofuran-2(3H)-one manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Brivaracetam Impurity 19 63095-51-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-06-27
Chengdu Aupone Pharmaceutical Co.Ltd.
Product
(R)-4-Propyldihydrofuran-2(3H)-one 63095-51-2
Price
US $0.00/KH
Min. Order
5KH
Purity
99
Supply Ability
10Tons
Release date
2024-06-14
Hebei Xinsheng New Material Technology Co., LTD.
Product
(R)-4-Propyldihydrofuran-2(3H)-one 63095-51-2
Price
US $35.00-25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 Ton
Release date
2023-11-16

63095-51-2, (R)-4-Propyldihydrofuran-2(3H)-oneRelated Search:

(R)-Ethyl 3-(bromomethyl)hexanoate Brivaracetam Impurity 10 Brivaracetam Impurity 14 (Z)-2-propylhept-2-enal INTERMEDIATES tert-Butyl (R)-4-(5-methyl-7-oxo-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)piperazine-1-carboxylate (R)-2-(2-(tert-butoxy)-2-oxoethyl)pentanoic acid Brivaracetam Impurity 21 Brivaracetam-d7 Dihydro-4-propyl-2(3H)-furanone Brivaracetam (alfaR, 4R)-Isomer tert-butyl (R)-3-(hydroxymethyl)hexanoate (4S)-BrivaracetaM Brivaracetam (alfaR, 4S)-Isomer Brivaracetam (Racemate) (R)-4-Propyldihydrofuran-2(3H)-one Brivaracetam brivaracetam intermediate 3

  • brivaracetam intermediate 1
  • Brivaracetam Intermediate
  • (R)-Dihydro-4-propyl-2(3H)-furanone
  • (R)-4-propyl-dihydro-furan-2-one
  • (R)-4-propyldihydrofuran-2(3H)-one
  • (+)-(R)-4-propyl-4,5-dihydrofuran-2(3H)-one
  • (4R)-4-Propyldihydrofuran-2(3H)-one
  • 2(3H)-Furanone,dihydro-4-propyl-,(R)-
  • Boisacetan
  • Brivaracetam Impurity 13
  • (+)-(R)-4-propyl-4,5-dihydroturan-2(3H)-one
  • 2(3H)-Furanone, dihydro-4-propyl-, (R)- (9CI)
  • (R)-4-propyl-4,5-dihydrofuran-2(3H)-one(BR50)
  • Brivaracetam Impurity 40
  • (+)-(R)-4-propyl-4,5- dihydrofuran-2(3H)-one
  • (R)-4-Propyldihydrofuran-2(3H)-one(For export only)
  • (R)-Dihydro-4-propylfuran-2(3H)-one
  • (4R)-4-propyloxolan-2-one
  • (4R)-4-propyltetrahydrofuran-2-one
  • Brisetan
  • (R)-4-Propyldihydrofuran-2(3H)-One/ Intermediate Of Brivaracetam
  • BR150
  • (R)-4-Propyldihydrofuran-2(3H)-one(Briveracetam KSM)
  • (R)-4-propyI-dihydro-furan-2-one
  • (R)-4-propylidihydrofuran-2(3H)-4-one
  • Buvacitan impurity 11
  • 63095-51-2