TH287

Product Name: TH287
CAS No.: 1609960-30-6
Chemical Name: TH287
Synonyms: TH287;CS-1671;Centicin;Septigen;TH287, >98%;TH287;TH-287;Oksitselanim;TH287 hydrochloride;6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine;6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine
CBNumber: CB82749064
Molecular Formula: C11H10Cl2N4
Formula Weight: 269.13
MOL File: 1609960-30-6.mol

More

Less

TH287 Property

Boiling point:: 512.2±60.0 °C(Predicted)
Density: 1.440±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
pka: 5.91±0.10(Predicted)
form: powder
color: white to beige

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1069
Product name: TH287 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $149
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML1069
Product name: TH287 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $527
Updated: 2022/05/15

Cayman Chemical

Product number: 18132
Product name: TH287
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 18132
Product name: TH287
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 18132
Product name: TH287
Purity: ≥98%
Packaging: 10mg
Price: $151
Updated: 2024/03/01

More

Less

TH287 Chemical Properties,Usage,Production

Description

Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC₅₀ = 0.8 nM) that selectively kills cancer cell lines (IC₅₀s = 0.8-3.06 μM) without significant cytotoxicity towards primary or immortalized cells (IC₅₀s = ≥20 μM). At up to 100 μM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).

Uses

6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine is known to possess antitumor effects and nanomolar MTH1-inhibitory activity in vitro for cancer cell survival.

References

1. gad h, koolmeister t, jemth as et al. mth1 inhibition eradicates cancer by preventing sanitation of the dntp pool. nature. 2014 apr 10;508(7495):215-21.

TH287 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

TH287 Suppliers

China 80 India 1 United Kingdom 1 United States 14 Global 96

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: meilunui@163.com
Country: China
ProdList: 4727
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ Bioscience CHINA

Tel: 025-58849295 18951903616;
Fax: 025-68650336
Email: info@adooq.cn
Country: China
ProdList: 2990
Advantage: 60

Shanghai JiYi Biotechnology Co. Ltd.

Tel: 13621943973
Fax: -
Email: sales@shjiyipharmatech.com
Country: China
ProdList: 1166
Advantage: 55

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4512
Advantage: 55

D&C Chemicals

Tel: +86-21-58447131
Fax: +86-21-61642470
Email: 1724405207@qq.com
Country: China
ProdList: 472
Advantage: 55

Guangzhou Zhiya Chemdrugs Co.,Ltd

Tel: 18122150900
Fax: QQ:2869377561
Email: sculk28@163.com
Country: China
ProdList: 646
Advantage: 55

Pharmacodia (Beijing) Co.,Ltd

Tel: +86-400-851-9921
Fax: +86-10-82826195
Email: sales@pharmacodia.com
Country: China
ProdList: 2317
Advantage: 55

More

Less

View Lastest Price from TH287 manufacturers

Career Henan Chemical Co

Product: TH287 1609960-30-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%~99%
Supply Ability: per week:100kg
Release date: 2019-09-05

1609960-30-6, TH287Related Search:

N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester TH588

TH287 hydrochloride

TH287

6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine

6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride

6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine

TH287;TH-287

CS-1671

TH287, >98%

2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-

6-(2,3-Dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine

Centicin

Oksitselanim

Septigen

6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine , TH287

1609960-30-6

Inhibitors