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TH287

Product Name
TH287
CAS No.
1609960-30-6
Chemical Name
TH287
Synonyms
TH287;CS-1671;Centicin;Septigen;TH287, >98%;TH287;TH-287;Oksitselanim;TH287 hydrochloride;6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine;6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine
CBNumber
CB82749064
Molecular Formula
C11H10Cl2N4
Formula Weight
269.13
MOL File
1609960-30-6.mol
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TH287 Property

Boiling point:
512.2±60.0 °C(Predicted)
Density 
1.440±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
pka
5.91±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
Xn
Risk Statements 
22-41
Safety Statements 
26-39
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1069
Product name
TH287 hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$149
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1069
Product name
TH287 hydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$527
Updated
2022/05/15
Cayman Chemical
Product number
18132
Product name
TH287
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18132
Product name
TH287
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
18132
Product name
TH287
Purity
≥98%
Packaging
10mg
Price
$151
Updated
2024/03/01
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TH287 Chemical Properties,Usage,Production

Description

Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC50 = 0.8 nM) that selectively kills cancer cell lines (IC50s = 0.8-3.06 μM) without significant cytotoxicity towards primary or immortalized cells (IC50s = ≥20 μM). At up to 100 μM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).

Uses

6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine is known to possess antitumor effects and nanomolar MTH1-inhibitory activity in vitro for cancer cell survival.

References

1. gad h, koolmeister t, jemth as et al. mth1 inhibition eradicates cancer by preventing sanitation of the dntp pool. nature. 2014 apr 10;508(7495):215-21.

TH287 Preparation Products And Raw materials

Raw materials

Preparation Products

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TH287 Suppliers

China 77 India 1 United Kingdom 1 United States 14 Global 93
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
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View Lastest Price from TH287 manufacturers

Career Henan Chemical Co
Product
TH287 1609960-30-6
Price
US $1.00/KG
Min. Order
1KG
Purity
95%~99%
Supply Ability
per week:100kg
Release date
2019-09-05

1609960-30-6, TH287Related Search:

N,N'-Bis(2-bromoethyl)phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester TH588

  • TH287 hydrochloride
  • TH287
  • 6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine
  • 6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride
  • 6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine
  • TH287;TH-287
  • CS-1671
  • TH287, >98%
  • 2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-
  • 6-(2,3-Dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine
  • Centicin
  • Oksitselanim
  • Septigen
  • 1609960-30-6
  • Inhibitors