ICA-105574

Product Name: ICA-105574
CAS No.: 316146-57-3
Chemical Name: ICA-105574
Synonyms: ICA-105574;3-nitro-N-(4-phenoxyphenyl)-benzamide;Benzamide, 3-nitro-N-(4-phenoxyphenyl)-;activator,KcsA,current amplitudes,ICA105574,ICA-105574,ICA 105574,Potassium Channel,inhibit,Inhibitor,hERG channel
CBNumber: CB82750387
Molecular Formula: C19H14N2O4
Formula Weight: 334.33
MOL File: 316146-57-3.mol

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ICA-105574 Property

Boiling point:: 430.9±30.0 °C(Predicted)
Density: 1.333±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: >20mg/mL
pka: 11.76±0.70(Predicted)
color: off-white to light tan
InChI: InChI=1S/C19H14N2O4/c22-19(14-5-4-6-16(13-14)21(23)24)20-15-9-11-18(12-10-15)25-17-7-2-1-3-8-17/h1-13H,(H,20,22)
InChIKey: GDWKBKTVROCPNZ-UHFFFAOYSA-N
SMILES: C(NC1=CC=C(OC2=CC=CC=C2)C=C1)(=O)C1=CC=CC([N+]([O-])=O)=C1

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Safety

Hazard Codes: Xi,N
Risk Statements: 36-43-50/53
Safety Statements: 26-36/37-60-61
RIDADR: UN 3077 9 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CBL0000327
Product name: ICA-105574
Purity: 95.00%
Packaging: 5MG
Price: $684.81
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CBL0000327
Product name: ICA-105574
Purity: 95.00%
Packaging: 25MG
Price: $977.48
Updated: 2021/12/16

DC Chemicals

Product number: DC22960
Product name: ICA-105574
Purity: >98%
Packaging: 1g
Price: $1800
Updated: 2021/12/16

DC Chemicals

Product number: DC22960
Product name: ICA-105574
Purity: >98%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

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ICA-105574 Chemical Properties,Usage,Production

Description

ICA-105574 is a potent and efficacious hERG channel activator. The primary mechanism by which ICA-105574 potentiates hERG channel activity is by removing hERG channel inactivation. ICA-105574 steeply potentiates current amplitudes more than 10-fold with an EC50 value of 0.5 +/- 0.1 μM and a Hill slope (n(H)) of 3.3 +/- 0.2. ICA-105574 shifts the voltage dependence of Ptype inactivation to a very positive direction and removes the hERG channel from inactivation at physiological membrane potentials[1].

References

[1] Mahoko Asayama . “Effects of an hERG Activator, ICA-105574, on Electrophysiological Properties of Canine Hearts.” Journal of pharmacological sciences 121 1 (2013): Pages 1-8.

ICA-105574 Preparation Products And Raw materials

Raw materials

Preparation Products

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ICA-105574 Suppliers

Canada 1 China 28 China Hong Kong 1 Russia 1 Ukraine 1 United States 3 Global 35

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9709
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2989
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9747
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3553
Advantage: 58

TopScience Biochemical

Tel: 00852-68527855
Fax: 00852-26406298
Email: info@itopbiochem.com
Country: China Hong Kong
ProdList: 902
Advantage: 58

Suzhou youruike Chemical Pharmaceutical Technology Co., Ltd

Tel: 15317229551
Fax: QQ:3607245178
Email: 15151849396@163.com
Country: China
ProdList: 997
Advantage: 58

ShangHai ChuanQian Chemcial Technique Centre

Tel: 15869524721
Email: 3525679403@qq.com
Country: China
ProdList: 3695
Advantage: 58

316146-57-3, ICA-105574Related Search:

3-nitro-N-(4-phenoxyphenyl)-benzamide

ICA-105574

Benzamide, 3-nitro-N-(4-phenoxyphenyl)-

activator,KcsA,current amplitudes,ICA105574,ICA-105574,ICA 105574,Potassium Channel,inhibit,Inhibitor,hERG channel

316146-57-3