ChemicalBook > CAS DataBase List > N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride

N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride

Product Name
N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride
CAS No.
864741-95-7
Chemical Name
N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride
Synonyms
SB 699551 dihydrochloride;SB 699551 dihydrochloride, 5-HT5A receptor antagonist;3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[[4-[4-[(2-phenylethylamino)methyl]phenyl]phenyl]methyl]propanamide;3-Cyclopentyl-N-(2-(dimethylamino)ethyl)-N-((4'-((phenethylamino)methyl)-[1,1'-biphenyl]-4-yl)methyl)propanamide dihydrochloride;3-Cyclopentyl-N-(2-(dimethylamino)ethyl)-N-((4'-((phenethylamino)methyl)-[1,1'-biphenyl]-4-yl)methyl)propanamide dihydrochloride
CBNumber
CB82750695
Molecular Formula
C34H46ClN3O
Formula Weight
548.21
MOL File
864741-95-7.mol
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N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride Property

storage temp. 
Inert atmosphere,2-8°C
solubility 
H2O: soluble1mg/mL, clear (warmed)
form 
powder
color 
white to beige
Water Solubility 
H2O: 1mg/mL, clear (warmed)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
46
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0853
Product name
SB 699551 dihydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$121
Updated
2025/07/31
Sigma-Aldrich
Product number
SML0853
Product name
SB 699551 dihydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$381
Updated
2025/07/31
Usbiological
Product number
465915
Product name
SB 699551 Dihydrochloride
Packaging
10mg
Price
$418
Updated
2021/12/16
TRC
Product number
S154755
Product name
SB 699551 dihydrochloride
Packaging
100mg
Price
$1095
Updated
2021/12/16
ApexBio Technology
Product number
B7308
Product name
SB699551
Packaging
50mg
Price
$1425
Updated
2021/12/16
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N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride Chemical Properties,Usage,Production

Uses

SB 699551 Dihydrochloride is a potent 5-HT5A receptor antagonist shown to mediate hypotension in anesthetized rats (1). May also be used as an antagonist in mediating the negative effects of schizophrenia. It is also used in the role of peripheral 5-HT5A receptors in 5-HT-induced cardiac sympatho-inhibition in type 1 diabetic rats.

Biological Activity

SB 699551 dihydrochloride is also known as (3-cyclopentyl-N-[2-(dimethylamino)ethyl]-N-[(4μ-{[(2-phenylethyl)amino]methyl}-4-biphenylyl)methyl]propanamide dihydrochloride). It is considered as a useful tool to explain the physiological roles of the 5-ht5A receptor.', 'SB-699551 is a 5-HT5A receptor antagonist, (pKi = 8.3) with 100-fold selectivity over other 5-HT receptor populations. SB-699551 completely blocks 5-HT-induced [35S]GTPγS membrane binding in cells expressing recombinant guinea pig 5-HT-5A.

in vivo

SB-699551 (25 mg/kg; i.p.; once daily; 3 weeks) reduced xenograft growth rate in a breast cancer xenograft model in NOD/SCID mice and synergized with Docetaxel to reduce xenograft size[3].
SB-699551 (0.3-3 mg/kg; i.p.; once) reversed drug-induced cognitive deficits in attention switching and novel object recognition tasks and improved social withdrawal in Sprague-Dawley rats[7].
SB-699551 (0.3-3 mg/kg; s.c.; once) co-treatment with Dizocilpine (HY-15084B) or Scopolamine (HY-N0296) reversed amnesia (long-term memory) in Wistar rats[8].

IC 50

5-HT5A Receptor: 8.3 (pKi)

storage

Store at +4°C

N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochloride Suppliers

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864741-95-7, N-[2-(Dimethylamino)ethyl]-N-[[4′-[[(2-phenylethyl)amino]methyl][1,1′-biphenyl]-4-yl]methyl]-cyclopentanepropanamide dihydrochlorideRelated Search:

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrate hydrochloride

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  • 3-Cyclopentyl-N-(2-(dimethylamino)ethyl)-N-((4'-((phenethylamino)methyl)-[1,1'-biphenyl]-4-yl)methyl)propanamide dihydrochloride
  • SB 699551 dihydrochloride, 5-HT5A receptor antagonist
  • 3-Cyclopentyl-N-(2-(dimethylamino)ethyl)-N-((4'-((phenethylamino)methyl)-[1,1'-biphenyl]-4-yl)methyl)propanamide dihydrochloride
  • 864741-95-7