H-GAMMA-GLU-GLY-OH

H-GAMMA-GLU-GLY-OH Property

Melting point:

193-194 °C

Boiling point:

586.6±50.0 °C(Predicted)

Density 

1.424±0.06 g/cm3(Predicted)

storage temp. 

-15°C

pka

2.21±0.10(Predicted)

form 

Solid

color 

White to off-white

Hazard and Precautionary Statements (GHS)

H-GAMMA-GLU-GLY-OH Chemical Properties,Usage,Production

Uses

γ-Glu-Gly, a γ-glutamyl dipeptide, is a human lipid metabolite.γ-Glu-Gly has a similar structure to GABA (γ-aminobutyric acid) and can act as an antagonist of excitatory amino acids[1][2][3].

Definition

ChEBI: A glutamyl-L-amino acid obtained by formal condensation of the gamma-carboxy group of glutamic acid with the amino group of glycine.

IC 50

Human Endogenous Metabolite

References

[1] Kit-Yi Leung, et al. Regulation of glycine metabolism by the glycine cleavage system and conjugation pathway in mouse models of non-ketotic hyperglycinemia. J Inherit Metab Dis. 2020 Nov;43(6):1186-1198. DOI:10.1002/jimd.12295
[2] Sonu Yadav, et al. Metabolomics shows the Australian dingo has a unique plasma profile. Sci Rep. 2021 Mar 4;11(1):5245. DOI:10.1038/s41598-021-84411-6
[3] Olga A Sofyanovich, et al. Multiple pathways for the formation of the γ-glutamyl peptides γ-glutamyl-valine and γ- glutamyl-valyl-glycine in Saccharomyces cerevisiae. PLoS One. 2019 May 9;14(5):e0216622. DOI:10.1371/journal.pone.0216622